Search Results - "KUZU, Ömer Faruk"
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Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer
Published in Oncogene (01-08-2019)“…Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded…”
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Targeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancer
Published in Nature communications (15-10-2024)“…Unfolded protein response (UPR) is a central stress response pathway that is hijacked by tumor cells for their survival. Here, we find that IRE1α signaling,…”
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IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
Published in Nature communications (24-01-2019)“…Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly…”
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The Role of High Dose Chemotherapy with Autologous Hematopoietic Cell Transplant in Relapsed/Refractory Ovarian Germ Cell Tumors: A Single Center Experience
Published in Clinical genitourinary cancer (01-08-2024)“…We aimed to investigate response rates, survival analyses and factors affecting survival in patients with relapsed or refractory ovarian germ cell tumours who…”
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Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy
Published in BMC cancer (10-02-2023)“…There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor…”
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Salvage Treatment for Extragonadal Germ Cell Tumours: High-Dose Chemotherapy and Autologous Stem Cell Transplantation Outcomes—A Single-Centre Experience
Published in Journal of clinical medicine (29-10-2024)“…Objective: Extragonadal germ cell tumours have a more unfavourable prognosis than gonadal germ cell tumours. We aimed to evaluate the survival analysis,…”
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Abstract 7416: GeneSetR: A web server for gene set analysis based on genome-wide Perturb-Seq data
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Identification of genotype-phenotype relationships is of utmost importance and a core effort in biology. Recent developments in efficient and precise…”
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Immunological facets of prostate cancer and the potential of immune checkpoint inhibition in disease management
Published in Theranostics (21-10-2024)Get full text
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STAMP2 Expression Mediated by Cytokines Attenuates Their Growth-Limiting Effects in Prostate Cancer Cells
Published in Cancers (30-03-2021)“…Inflammatory events and dysregulated cytokine expression are implicated in prostate cancer (PCa), but the underlying molecular mechanisms are poorly understood…”
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The impact of transfusion burden and comorbidities on the prognosis of patients with myelodysplastic syndromes
Published in Transfusion and apheresis science (01-10-2020)“…Early comorbidity detection has been reported to be associated with treatment-related outcomes in several diseases. Two main goals of the present study were to…”
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Abstract 5362: Targeting IRE1α alleviates the immunosuppressive tumor microenvironment in prostate cancer
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Unfolded protein response (UPR) is a central stress response pathway in normal cells that is hijacked by tumor cells for their survival. However, how…”
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Evaluation of clinical and prognostic factors for primary gastric diffuse large B-cell lymphoma: Single-center experience
Published in Journal of cancer research and therapeutics (01-07-2023)“…Objective: Primary gastric lymphomas, which make up the vast majority of extranodal non-Hodgkin lymphoma, are rare and the most common subtype is primary…”
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