Search Results - "KUYPERS, Frans A"

Mammalian long-chain acyl-CoA synthetases by Soupene, Eric, Kuypers, Frans A

“…Acyl-CoA synthetase enzymes are essential for de novo lipid synthesis, fatty acid catabolism, and remodeling of membranes. Activation of fatty acids requires a…”
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ACBD6 protein controls acyl chain availability and specificity of the N-myristoylation modification of proteins[S] by Soupene, Eric, Kuypers, Frans A.

“…Members of the human acyl-CoA binding domain-containing (ACBD) family regulate processes as diverse as viral replication, stem-cell self-renewal, organelle…”
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Blood draw site and analytic device influence hemoglobin measurements by Killilea, David W, Kuypers, Frans A, Larkin, Sandra K, Schultz, Kathleen

“…Anemia is a continuing global public health concern and a priority for international action. The prevalence of anemia is estimated from the hemoglobin (Hb)…”
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The diversity of ACBD proteins – From lipid binding to protein modulators and organelle tethers by Islinger, Markus, Costello, Joseph L., Kors, Suzan, Soupene, Eric, Levine, Timothy P., Kuypers, Frans A., Schrader, Michael

“…Members of the large multigene family of acyl-CoA binding domain containing proteins (ACBDs) share a conserved motif required for binding of Coenzyme A…”
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Hemoglobin S Polymerization and Red Cell Membrane Changes by Kuypers, Frans A., PhD

“…Different pathways lead from the simple point mutation in hemoglobin to the membrane changes that characterize the altered interaction of the sickle red blood…”
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Effect of voxelotor on cardiopulmonary testing in youths with sickle cell anemia in a pilot study by Phan, Vivian, Hershenson, Jared, Caldarera, Laura, Larkin, Sandra K., Wheeler, Kari, Cortez, Ana Lucia, Dulman, Robin, Briere, Noravy, Lewis, Angela, Kuypers, Frans A., Yang, Elizabeth

“…Background Individuals with sickle cell anemia (SCA) exhibit decreased exercise capacity. Anemia limits oxygen‐carrying capacity and affects cardiopulmonary…”
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Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model by Bell, Robert L, Withers, Ginger S, Kuypers, Frans A, Stehr, Wolfgang, Bhargava, Aditi

“…The etiology of necrotizing enterocolitis (NEC) is not known. Alterations in gut microbiome, mucosal barrier function, immune cell activation, and blood flow…”
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Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes by Soupene, Eric, Kuypers, Frans A.

“…The binding determinants of the human acyl-CoA binding domain-containing protein (ACBD) 6 and its function in lipid renewal of membranes were investigated…”
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Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins by Soupene, Eric, Kuypers, Frans A

“…The transfer of acyl chains to proteins and lipids from acyl-CoA donor molecules is achieved by the actions of diverse enzymes and proteins, including the…”
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Common host variation drives malaria parasite fitness in healthy human red cells by Ebel, Emily R, Kuypers, Frans A, Lin, Carrie, Petrov, Dmitri A, Egan, Elizabeth S

“…The replication of parasites within red blood cells (RBCs) causes severe disease in humans, especially in Africa. Deleterious alleles like hemoglobin S are…”
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The RoxyScan is a novel measurement of red blood cell deformability under oxidative and shear stress by Larkin, Sandra K., Hernández, Carolina, van Beers, Eduard J., van Wijk, Richard, Kuypers, Frans A.

“…Exposure to both oxidative and shear stress, a condition that the red blood cell (RBC) continuously experiences in the circulation in vivo can be mimicked in a…”
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Requirement of the acyl-CoA carrier ACBD6 in myristoylation of proteins: Activation by ligand binding and protein interaction by Soupene, Eric, Schatz, Ulrich A, Rudnik-Schöneborn, Sabine, Kuypers, Frans A

“…Glycine N-myristoylation is an essential acylation modification modulating the functions, stability, and membrane association of diverse cytosolic proteins in…”
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A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes by Morris, Claudia R, Kuypers, Frans A, Lavrisha, Lisa, Ansari, Michael, Sweeters, Nancy, Stewart, Melinee, Gildengorin, Ginny, Neumayr, Lynne, Vichinsky, Elliott P

“…Painful episodes of vaso-occlusion are the leading cause of hospitalizations and emergency department visits in sickle cell disease, and are associated with…”
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Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes by Soupene, Eric, Fyrst, Henrik, Kuypers, Frans A

“…The mammalian RBC lacks de novo lipid synthesis but maintains its membrane composition by rapid turnover of acyl moieties at the sn-2 position of…”
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The effects of glutamine supplementation on markers of apoptosis and autophagy in sickle cell disease peripheral blood mononuclear cells by Walter, Patrick B., Hohman, Leah S., Rokeby, Andrew, Lum, Julian J., Hagar, Robert, Lavrisha, Lisa, Saulys, Augusta, Kuypers, Frans A., Vichinsky, Elliott, Morris, Claudia R.

“…L-Glutamine was FDA-approved for sickle cell disease (SCD) in 2017, yet the mechanism(s)-of-action are poorly understood. This study investigates the potential…”
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Implications for the metabolic fate of oral glutamine supplementation within plasma and erythrocytes of patients with sickle cell disease: A pharmacokinetics study by Morris, Claudia R., Kuypers, Frans A., Hagar, Robert, Larkin, Sandra, Lavrisha, Lisa, Saulys, Augusta, Vichinsky, Elliott P., Suh, Jung H.

“…L-Glutamine is FDA-approved for sickle cell disease (SCD), yet the mechanism(s)-of-action are poorly understood. We performed a pharmacokinetics (pK) study to…”
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Hyperinflammation, apoptosis, and organ damage by Kuypers, Frans A

“…The cytokine storm (CS) in hyperinflammation is characterized by high levels of cytokines, extreme activation of innate as well as adaptive immune cells and…”
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The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism by Johnson, Robert M., Ho, Ye-Shih, Yu, Dae-Yeul, Kuypers, Frans A., Ravindranath, Yaddanapudi, Goyette, Gerard W.

“…Peroxiredoxin-2 (Prdx2), a potent peroxide reductant, is the third most abundant protein in the erythrocyte and might be expected to play a major role in the…”
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Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease by Morris, Claudia R., Suh, Jung H., Hagar, Ward, Larkin, Sandra, Bland, D. Anton, Steinberg, Martin H., Vichinsky, Elliott P., Shigenaga, Mark, Ames, Bruce, Kuypers, Frans A., Klings, Elizabeth S.

“…Erythrocyte glutathione depletion has been linked to hemolysis and oxidative stress. Glutamine plays an additional antioxidant role through preservation of…”
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Decreased Arginine Bioavailability and Increased Serum Arginase Activity in Asthma by Morris, Claudia R, Poljakovic, Mirjana, Lavrisha, Lisa, Machado, Lorenzo, Kuypers, Frans A, Morris, Sidney M., Jr

“…Recent studies suggest that a nitric oxide (NO) deficiency and elevated arginase activity may play a role in the pathogenesis of asthma. Although much…”
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