Search Results - "KUTSCHER, B"

D-21266, a new heterocyclic alkylphospholipid with antitumour activity by Hilgard, P., Klenner, T., Stekar, J., Nössner, G., Kutscher, B., Engel, J.

“…The aim of this study was to determine the antitumour effects of D-21266 in a rodent tumour model. Hexadecylphosphocholine (INN: Miltefosine) represents the…”
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New small-molecule tubulin inhibitors by Bacher, G., Beckers, T., Emig, P., Klenner, T., Kutscher, B., Nickel, B.

“…The variety of biological agents directed toward the tubulin system exceeds those acting on DNA, making it an important target for cancer chemotherapy…”
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New N-(Pyridin-4-yl)-(indol-3-yl)acetamides and Propanamides as Antiallergic Agents by Menciu, Cecilia, Duflos, Muriel, Fouchard, Fabienne, Le Baut, Guillaume, Emig, Peter, Achterrath, Ute, Szelenyi, Istvan, Nickel, Bernd, Schmidt, Jürgen, Kutscher, Bernhard, Günther, Eckhardt

“…A series of new N-(pyridin-4-yl)-(indol-3-yl)alkylamides 44 − 84 has been prepared in the search of novel antiallergic compounds. Synthesis of the desired…”
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Studies on the synthesis of cyclic pentapeptides as LHRH antagonists and the factors that influence cyclization yield by Gao, Xing-Ming, Ye, Yun-Hua, Bernd, Michael, Kutscher, Bernhard

“…Six cyclic pentapeptides containing two or three non‐protein amino acids have been synthesized by cyclization of linear precursors in dilute solution and…”
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Stability of several LHRH antagonists against proteolytic enzymes and identification of degradation products by mass spectrometry by Braun, K, Kuhl, P, Bernd, M, Kutscher, B

“…In this study stabilities of several LHRH antagonists against proteolytic enzymes are compared. For the enzymatic tests 15 proteases which differ in both…”
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1,5-Disubstituted Indazol-3-ols with Anti-Inflammatory Activity by Schindler, Rudolf, Fleischhauer, Ilona, Höfgen, Norbert, Sauer, Wolfgang, Egerland, Ute, Poppe, Hildegard, Heer, Sabine, Szelenyi, Istvan, Kutscher, Bernhard, Engel, Jürgen

“…A series of new indazol‐3‐ol derivatives was synthesized. Some of these compounds exhibit interesting anti‐inflammatory activities in various models of…”
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Sequence and Length Recognition of the C-terminal Turnover Element of LpxC, a Soluble Substrate of the Membrane-bound FtsH Protease by Führer, Frank, Müller, Alexandra, Baumann, Holger, Langklotz, Sina, Kutscher, Blanka, Narberhaus, Franz

“…The membrane-anchored FtsH protease is essential in Escherichia coli as it adjusts the cellular amount of LpxC, the key enzyme in lipopolysaccharide (LPS)…”
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Structural investigation of Cetrorelix, a new potent and long-acting LH-RH antagonist by Müller, A, Busker, E, Engel, J, Kutscher, B, Bernd, M, Schally, A V

“…The new decapeptide SB-75 (INN: Cetrorelix) has been characterized as a potent antagonist of luteinizing-hormone releasing hormone (LH-RH). Such derivatives…”
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Tell Me with Whom You're Learning, and I'll Tell You How Much You've Learned: Mixed-Ability versus Same-Ability Grouping in Mathematics by Linchevski, Liora, Kutscher, Bilha

“…In this article we report on 3 studies in which we investigated the effects of teaching mathematics in a mixed-ability setting on students' achievements and…”
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Structure–Function Studies of Linear and Cyclized Peptide Antagonists of the GnRH Receptor by Beckers, Thomas, Bernd, Michael, Kutscher, Bernd, Kühne, Ronald, Hoffmann, Silke, Reissmann, Thomas

“…Structurally new analogs of the peptidic GnRH receptor antagonist Cetrorelix as well as conformationally constrained cyclized deca- or pentapeptides were…”
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Evaluation of the in vitro and in vivo activity of the L-, D,L- and D-Cit6 forms of the LH-RH antagonist Cetrorelix (SB-75) by Pinski, J, Schally, A V, Yano, T, Groot, K, Srkalovic, G, Serfozo, P, Reissmann, T, Bernd, M, Deger, W, Kutscher, B

“…The objective of this study was to examine the in vivo and in vitro gonadotropin-inhibiting potencies, edematogenic activities and the receptor binding…”
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D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures by Rostock, Angelika, Tober, Christine, Rundfeldt, Chris, Bartsch, Reni, Engel, Jürgen, Polymeropoulos, Emanuele E., Kutscher, Bernhard, Löscher, Wolfgang, Hönack, Dagmar, White, H.Steve, Wolf, Harold H.

“…The anticonvulsant activity of the novel drug D-23129 ( N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester) was evaluated in animal models of…”
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Synthesis and antitumor activity of two ifosfamide analogs with a five-membered ring by Kutscher, B, Niemeyer, U, Engel, J, Kleemann, A, Hilgard, P, Pohl, J, Scheffler, G

“…Two ifosfamide (CAS 3778-73-2) analogs with a five-membered ring, i.e. the oxazaphospholidine derivatives 6 and 7, were synthesized and their cytotoxic…”
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Early stage monitoring of miltefosine induced apoptosis in KB cells by multinuclear NMR spectroscopy by Engelmann, J, Henke, J, Willker, W, Kutscher, B, Nössner, G, Engel, J, Leibfritz, D

“…Synthetic ether lipids, like miltefosine (hexadecylphosphocholine), an alkylphosphocholine, are antineoplastic agents in vitro and in vivo. Their mode of…”
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Glossary of terms used in computational drug design (IUPAC Recommendations 1997) by van de Waterbeemd, H., Carter, R. E., Grassy, G., Kubinyi, H., Martin, Y. C., Tute, M. S., Willett, P.

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BENZODIAZA-, BENZOXAZA-, AND BENZODIOXAPHOSPHORINONES - FORMATION, REACTIVITY, STRUCTURE, AND BIOLOGICAL ACTIVITY by Neda, Ion, Kaukorat, Thomas, Schmutzler, Reinhard, Niemeyer, Ulf, Kutscher, Bernhard, Pohl, Jörg

“…Although diverse phosphorus-containing heterocycles had been synthe-sized during the late nineteenth century already, work was still sparse in this area as…”
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Synthesis of dolastatin 15 mimetic peptoids by Schmitt, Jörg, Bernd, Michael, Kutscher, Bernhard, Kessler, Horst

“…Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella…”
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Changes of intracellular calcium, fatty acids and phospholipids during miltefosine-induced apoptosis monitored by fluorescence- and 13C NMR-spectroscopy by Henke, J, Engelmann, J, Kutscher, B, Nssner, G, Engel, J, Voegeli, R, Leibfritz, D

“…The alkylphosphocholine Miltefosine (hexadecylphosphocholine, HePC) induces apoptosis in human epithelial KB cells, whereas no such effect can be observed in a…”
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Polymorphism and desolvation of flupirtine maleate by Landgraf, Karl-Friedrich, Olbrich, Alfred, Pauluhn, Siegfried, Emig, Peter, Kutscher, Bernhard, Stange, Hans

“…Crystallizates of the analgesic agent flupirtine maleate (Katadolon®; ASTA Medica, Dresden, Germany) obtained from isopropanol are examined by X-ray…”
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Chemical and biological evaluation of hydrolysis products of cyclophosphamide by Gilard, V, Martino, R, Malet-Martino, M C, Kutscher, B, Müller, A, Niemeyer, U, Pohl, J, Polymeropoulos, E E

“…31P NMR spectroscopy was used to study the products of the decomposition of cyclophosphamide (1) in buffered solutions at pH's ranging between 1.2 and 8.6 at…”
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