Search Results - "KUSHNER, H"

Murine Anti-GD2 Monoclonal Antibody 3F8 Combined With Granulocyte-Macrophage Colony-Stimulating Factor and 13-Cis-Retinoic Acid in High-Risk Patients With Stage 4 Neuroblastoma in First Remission by CHEUNG, Nai-Kong V, CHEUNG, Irene Y, KUSHNER, Brian H, OSTROVNAYA, Irina, CHAMBERLAIN, Elizabeth, KRAMER, Kim, MODAK, Shakeel

“…Anti-GD2 monoclonal antibody (MoAb) combined with granulocyte-macrophage colony-stimulating factor (GM-CSF) has shown efficacy against neuroblastoma (NB)…”
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Key role for myeloid cells: Phase II results of anti‐GD2 antibody 3F8 plus granulocyte‐macrophage colony‐stimulating factor for chemoresistant osteomedullary neuroblastoma by Cheung, Nai‐Kong V., Cheung, Irene Y., Kramer, Kim, Modak, Shakeel, Kuk, Deborah, Pandit‐Taskar, Neeta, Chamberlain, Elizabeth, Ostrovnaya, Irina, Kushner, Brian H.

“…Anti‐GD2 murine antibody 3F8 plus subcutaneously (sc) administered granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) was used against primary…”
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A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors by Becher, Oren J, Millard, Nathan E, Modak, Shakeel, Kushner, Brian H, Haque, Sofia, Spasojevic, Ivan, Trippett, Tanya M, Gilheeney, Stephen W, Khakoo, Yasmin, Lyden, David C, De Braganca, Kevin C, Kolesar, Jill M, Huse, Jason T, Kramer, Kim, Cheung, Nai-Kong V, Dunkel, Ira J

“…The PI3K/Akt/mTOR signaling pathway is aberrantly activated in various pediatric tumors. We conducted a phase I study of the Akt inhibitor perifosine in…”
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Caregiver object labels within supported and coordinated joint engagement during interaction with toddlers at elevated and typical likelihood of autism by Kushner, Elizabeth H., Britsch, Emily Roemer, Iverson, Jana M.

“…Background Early in development, caregivers’ object labelling contributes to children's word learning. Language development is a bi‐directional process, and…”
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Adoptive immunotherapy with haploidentical natural killer cells and Anti-GD2 monoclonal antibody m3F8 for resistant neuroblastoma: Results of a phase I study by Modak, Shakeel, Le Luduec, Jean-Benoit, Cheung, Irene Y., Goldman, Debra A., Ostrovnaya, Irina, Doubrovina, Ekaterina, Basu, Ellen, Kushner, Brian H., Kramer, Kim, Roberts, Stephen S., O'Reilly, Richard J., Cheung, Nai-Kong V., Hsu, Katharine C.

“…Natural killer (NK) cell-mediated antibody-dependent toxicity is a potent mechanism of action of the anti-GD2 murine monoclonal antibody 3F8 (m3F8). Killer…”
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Neuroblastoma: A Disease Requiring a Multitude of Imaging Studies by Kushner, Brian H

“…Neuroblastoma stands out among pediatric solid tumors because of its relative frequency, intriguing natural history, prognostic biologic features, and…”
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Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma by Casey, Dana L., MD, Kushner, Brian H., MD, Cheung, Nai-Kong V., MD, PhD, Modak, Shakeel, MD, LaQuaglia, Michael P., MD, Wolden, Suzanne L., MD

“…Purpose To evaluate local control after 21-Gy radiation therapy (RT) to the primary site in patients with high-risk neuroblastoma. Methods and Materials After…”
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Outpatient administration of naxitamab in combination with granulocyte‐macrophage colony‐stimulating factor in patients with refractory and/or relapsed high‐risk neuroblastoma: Management of adverse events by Mora, Jaume, Chan, Godfrey C., Morgenstern, Daniel A., Nysom, Karsten, Bear, Melissa K., Tornøe, Karen, Kushner, Brian H.

“…Background Naxitamab is a humanized GD2‐binding monoclonal antibody that received accelerated approval from the U.S. Food and Drug Administration for…”
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Skeletal muscle metastases in neuroblastoma share common progenitors with primary tumor and biologically resemble stage MS disease by Fong, Christina, Kushner, Brian H, Di Giannatale, Angela, Gundem, Gunes, Li, Shanita, Roberts, Stephen S, Basu, Ellen M, Price, Anita, Cheung, Nai-Kong V, Modak, Shakeel

“…While subcutaneous metastases are often observed with stage MS neuroblastoma, an entity that usually resolves spontaneously, skeletal muscle metastases (SMM)…”
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Irinotecan Plus Temozolomide for Relapsed or Refractory Neuroblastoma by KUSHNER, Brian H, KRAMER, Kim, MODAK, Shakeel, CHEUNG, Nai-Kong V

“…To report on an irinotecan and temozolomide regimen for neuroblastoma (NB). Quality of life and minimizing toxicity were major considerations. The plan…”
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Phase I trial of anti-GD2 monoclonal antibody hu3F8 plus GM-CSF: Impact of body weight, immunogenicity and anti-GD2 response on pharmacokinetics and survival by Cheung, Irene Y., Kushner, Brian H., Modak, Shakeel, Basu, Ellen M., Roberts, Stephen S., Cheung, Nai-Kong V.

“…Fifty-seven stage 4 patients with refractory/relapsed neuroblastoma were enrolled in a phase I trial (Clinicaltrials.gov NCT01757626) using humanized anti-GD2…”
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Long Prime-Boost Interval and Heightened Anti-GD2 Antibody Response to Carbohydrate Cancer Vaccine by Cheung, Irene Y, Mauguen, Audrey, Modak, Shakeel, Basu, Ellen M, Feng, Yi, Kushner, Brian H, Cheung, Nai Kong

“…The carbohydrate ganglioside GD2/GD3 cancer vaccine adjuvanted by β-glucan stimulates anti-GD2 IgG1 antibodies that strongly correlate with improved…”
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Sensitivity of Surveillance Studies for Detecting Asymptomatic and Unsuspected Relapse of High-Risk Neuroblastoma by KUSHNER, Brian H, KRAMER, Kim, MODAK, Shakeel, CHEUNG, Nai-Kong V

“…Relapse-free survival (RFS) is a powerful measure of treatment efficacy. We describe the sensitivity of standard surveillance studies for detecting relapse of…”
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Ifosfamide, carboplatin, and etoposide for neuroblastoma by Kushner, Brian H., Modak, Shakeel, Kramer, Kim, Basu, Ellen M., Roberts, Stephen S., Cheung, Nai‐Kong V.

“…BACKGROUND: The authors report a retrospective analysis of high‐dose ifosfamide, carboplatin, and etoposide (HD‐ICE) for patients with refractory or relapsed…”
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Phase 1 study of intraventricular 131I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies by Kramer, Kim, Pandit-Taskar, Neeta, Kushner, Brian H, Zanzonico, Pat, Humm, John L, Tomlinson, Ursula, Donzelli, Maria, Wolden, Suzanne L, Haque, Sophia, Dunkel, Ira, Souweidane, Mark M, Greenfield, Jeffrey P, Tickoo, Satish, Lewis, Jason S, Lyashchenko, Serge K, Carrasquillo, Jorge A, Chu, Bae, Horan, Christopher, Larson, Steven M, Cheung, Nai-Kong V, Modak, Shakeel

“…Abstract Background The prognosis for metastatic and recurrent tumors of the central nervous system (CNS) remains dismal, and the need for newer therapeutic…”
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FCGR2A Polymorphism Is Correlated With Clinical Outcome After Immunotherapy of Neuroblastoma With Anti-GD2 Antibody and Granulocyte Macrophage Colony-Stimulating Factor by CHEUNG, Nai-Kong V, SOWERS, Rebecca, VICKERS, Andrew J, CHEUNG, Irene Y, KUSHNER, Brian H, GORLICK, Richard

“…Anti-GD2 murine IgG3 antibody 3F8 kills neuroblastoma cells by antibody-dependent cell-mediated cytotoxicity (ADCC). Granulocyte macrophage colony-stimulating…”
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Phase II Trial of the Anti-GD2 Monoclonal Antibody 3F8 and Granulocyte-Macrophage Colony-Stimulating Factor for Neuroblastoma by KUSHNER, Brian H, KRAMER, Kim, CHEUNG, Nai-Kong V

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Long-term Pulmonary Outcomes in Pediatric Survivors of High-risk Neuroblastoma by Stone, Anne, Novetsky Friedman, Danielle, Worgall, Stefan, Kushner, Brian H, Wolden, Suzanne, Modak, Shakeel, LaQuaglia, Michael P, Wu, Xian, Cheung, Nai-Kong, Sklar, Charles A

“…Children with high-risk neuroblastoma are exposed to multimodality therapies early in life and survivors confront late therapy-related toxicities. This study…”
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Reduced Toxicity With Intensity Modulated Radiation Therapy (IMRT) for Desmoplastic Small Round Cell Tumor (DSRCT): An Update on the Whole Abdominopelvic Radiation Therapy (WAP-RT) Experience by Desai, Neil B., MD, MHS, Stein, Nicholas F., MS, LaQuaglia, Michael P., MD, Alektiar, Kaled M., MD, Kushner, Brian H., MD, Modak, Shakeel, MD, Magnan, Heather M., MD, Goodman, Karyn, MD, Wolden, Suzanne L., MD

“…Purpose Desmoplastic small round cell tumor (DSRCT) is a rare malignancy typically involving the peritoneum in young men. Whole abdominopelvic radiation…”
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Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants by Gerald, W L, Ladanyi, M, de Alava, E, Cuatrecasas, M, Kushner, B H, LaQuaglia, M P, Rosai, J

“…Intense investigation has reshaped concepts about undifferentiated tumors occurring in young people (small round-cell tumors). Tumors associated with…”
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