Search Results - "KUSEWITT, Donna F"

The hairless mouse in skin research by Benavides, Fernando, Oberyszyn, Tatiana M, VanBuskirk, Anne M, Reeve, Vivienne E, Kusewitt, Donna F

“…Abstract The hairless ( Hr ) gene encodes a transcriptional co-repressor highly expressed in the mammalian skin. In the mouse, several null and hypomorphic Hr…”
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Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia by Wang, Lisheng, Wang, Jie, Blaser, Bradley W., Duchemin, Anne-Marie, Kusewitt, Donna F., Liu, Tom, Caligiuri, Michael A., Briesewitz, Roger

“…Entry into the cell cycle is mediated by cyclin-dependent kinase 4/6 (CDK4/6) activation, followed by CDK2 activation. We found that pharmacologic inhibition…”
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Oral Tolerance to Environmental Mycobacteria Interferes with Intradermal, but Not Pulmonary, Immunization against Tuberculosis by Price, Dominique N, Kusewitt, Donna F, Lino, Christopher A, McBride, Amber A, Muttil, Pavan

“…Bacille Calmette-Guérin (BCG) is currently the only approved vaccine against tuberculosis (TB) and is administered in over 150 countries worldwide. Despite its…”
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Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2) by Hudson, Laurie G, Newkirk, Kimberly M, Chandler, Heather L, Choi, Changsun, Fossey, Stacey L, Parent, Allison E, Kusewitt, Donna F

“…Abstract Background Keratinocytes at wound margins undergo partial epithelial to mesenchymal transition (EMT). Based on previous in vitro and ex vivo findings,…”
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Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses by Lange, Sabine S, Bedford, Ella, Reh, Shelley, Wittschieben, John P, Carbajal, Steve, Kusewitt, Donna F, DiGiovanni, John, Wood, Richard D

“…DNA polymerase ζ (polζ) is critical for bypass of DNA damage and the associated mutagenesis, but also has unique functions in mammals. It is required for…”
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Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene by Ludes-Meyers, John H, Kil, Hyunsuk, Parker-Thornburg, Jan, Kusewitt, Donna F, Bedford, Mark T, Aldaz, C Marcelo

“…WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor…”
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Gender differences in UVB-induced skin carcinogenesis, inflammation, and DNA damage by THOMAS-AHNER, Jennifer M, WUIFF, Brian C, TOBER, Kathleen L, KUSEWITT, Donna F, RIGGENBACH, Judy A, OBERYSZYN, Tatiana M

“…The American Cancer Society reports the incidence of squamous cell carcinoma in males to be thrice the incidence in females. This increased squamous cell…”
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Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes by Savagner, Pierre, Kusewitt, Donna F., Carver, Ethan A., Magnino, Fabrice, Choi, Chagsun, Gridley, Thomas, Hudson, Laurie G.

“…During re‐epithelialization of cutaneous wounds, keratinocytes recapitulate several aspects of the embryonic process of epithelial‐mesenchymal transition…”
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Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance by Takata, Kei-Ichi, Reh, Shelley, Yousefzadeh, Matthew J, Zelazowski, Maciej J, Bhetawal, Sarita, Trono, David, Lowery, Megan G, Sandoval, Maria, Takata, Yoko, Lu, Yue, Lin, Kevin, Shen, Jianjun, Kusewitt, Donna F, McBride, Kevin M, Cole, Francesca, Wood, Richard D

“…DNA polymerase ν (pol ν), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an in-depth…”
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Longitudinal Assessment of Lung Cancer Progression in Mice Using the Sodium Iodide Symporter Reporter Gene and SPECT/CT Imaging by Price, Dominique N, McBride, Amber A, Anton, Martina, Kusewitt, Donna F, Norenberg, Jeffrey P, MacKenzie, Debra A, Thompson, Todd A, Muttil, Pavan

“…Lung cancer has the highest mortality rate of any tissue-specific cancer in both men and women. Research continues to investigate novel drugs and therapies to…”
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Differential effects of topical vitamin E and C E Ferulic® treatments on ultraviolet light B-induced cutaneous tumor development in Skh-1 mice by Burns, Erin M, Tober, Kathleen L, Riggenbach, Judith A, Kusewitt, Donna F, Young, Gregory S, Oberyszyn, Tatiana M

“…Because of the ever-increasing incidence of ultraviolet light B (UVB)-induced skin cancer, considerable attention is being paid to prevention through the use…”
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The skinny on slug by Shirley, Stephanie H., Hudson, Laurie G., He, Jing, Kusewitt, Donna F.

“…The zinc finger transcription factor Slug (Snai2) serves a wide variety of functions in the epidermis, with roles in skin development, hair growth, wound…”
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A mouse model for the carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues by KIRSCHNER, Lawrence S, KUSEWITT, Donna F, MATYAKHINA, Ludmila, TOWNS, William H, AIDAN CARNEY, J, WESTPHAL, Heiner, STRATAKIS, Constantine A

“…Carney complex is an autosomal dominant neoplasia syndrome characterized by spotty skin pigmentation, myxomatosis, endocrine tumors, and schwannomas. This…”
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Slug/Snai2 Is a Downstream Mediator of Epidermal Growth Factor Receptor-Stimulated Reepithelialization by Kusewitt, Donna F., Choi, Changsun, Newkirk, Kimberly M., Leroy, Pascale, Li, Yafan, Chavez, Miquella G., Hudson, Laurie G.

“…Many peptide growth factors, including EGFR ligands, accelerate wound reepithelialization in vivo and in vitro. Furthermore, EGFR expression is transiently…”
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Glyoxal leads to defective keratinocyte migration and down-regulation of Snai2 by Quan, Krystle K, Kusewitt, Donna F, Hudson, Laurie G

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Macrophage migration inhibitory factor (MIF) plays a critical role in pathogenesis of ultraviolet‐B (UVB) ‐induced nonmelanoma skin cancer (NMSC) by Martin, Jason, Duncan, F. Jason, Keiser, Tracy, Shin, Samuel, Kusewitt, Donna F., Oberyszyn, Tatiana, Satoskar, Abhay R., VanBuskirk, Anne M.

“…Mounting evidence suggests that macrophage migration inhibitory factor (MIF) may serve as an important link between chronic inflammation and cancer…”
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Importance of the EP1 Receptor in Cutaneous UVB-Induced Inflammation and Tumor Development by Tober, Kathleen L., Wilgus, Traci A., Kusewitt, Donna F., Thomas-Ahner, Jennifer M., Maruyama, Takayuki, Oberyszyn, Tatiana M.

“…Chronic exposure to UV light, the primary cause of skin cancer, results in the induction of high levels of cyclooxygenase-2 (COX-2) expression in the skin. The…”
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Two Hypomorphic Alleles of Mouse Ass1 as a New Animal Model of Citrullinemia Type I and Other Hyperammonemic Syndromes by Perez, Carlos J, Jaubert, Jean, Guénet, Jean-Louis, Barnhart, Kirstin F, Ross-Inta, Catherine M, Quintanilla, Vicente C, Aubin, Isabelle, Brandon, Jimi L, Otto, Nancy W, DiGiovanni, John, Gimenez-Conti, Irma, Giulivi, Cecilia, Kusewitt, Donna F, Conti, Claudio J, Benavides, Fernando

“…Citrullinemia type I (CTLN1, OMIM# 215700) is an inherited urea cycle disorder that is caused by an argininosuccinate synthetase (ASS) enzyme deficiency. In…”
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Role of the epidermal growth factor receptor in ultraviolet radiation induction of Snail family transcription factors by Shirley, Stephanie H, Hammiller, Brianna, Hansen, Laura A, Crysup, Benjamin, Hudson, Laurie G, Kusewitt, Donna F

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GPER expression prevents estrogen-induced urinary retention in obese mice by Kusewitt, Donna F., Sharma, Geetanjali, Woods, Christine D., Rosas, Emmanuel, Hathaway, Helen J., Prossnitz, Eric R.

“…Long-term administration of exogenous estrogen is known to cause urinary retention and marked, often fatal, bladder distention in both male and female mice…”
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