Search Results - "KUSAKABE, Toru"

Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy by Inoue, Takayuki, Saito, Satoshi, Tanaka, Masashi, Yamakage, Hajime, Kusakabe, Toru, Shimatsu, Akira, Ihara, Masafumi, Satoh-Asahara, Noriko

“…Cerebral amyloid angiopathy (CAA) results from amyloid-β deposition in the cerebrovasculature. It is frequently accompanied by Alzheimer’s disease and causes…”
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Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality by Akamatsu, Yasunori, Kusakabe, Toru, Arai, Hiroshi, Yamamoto, Yuji, Nakao, Kazuwa, Ikeue, Kentaro, Ishihara, Yuki, Tagami, Tetsuya, Yasoda, Akihiro, Ishii, Kojiro, Satoh‐Asahara, Noriko

“…Background Methods that facilitate muscle quality measurement may improve the diagnosis of sarcopenia. Current research has focused on the phase angle (PhA)…”
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Prediction of functional profiles of gut microbiota from 16S rRNA metagenomic data provides a more robust evaluation of gut dysbiosis occurring in Japanese type 2 diabetic patients by Inoue, Ryo, Ohue-Kitano, Ryuji, Tsukahara, Takamitsu, Tanaka, Masashi, Masuda, Shinya, Inoue, Takayuki, Yamakage, Hajime, Kusakabe, Toru, Hasegawa, Koji, Shimatsu, Akira, Satoh-Asahara, Noriko

“…We assessed whether gut microbial functional profiles predicted from 16S rRNA metagenomics differed in Japanese type 2 diabetic patients. A total of 22…”
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Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways by Inoue, Takayuki, Tanaka, Masashi, Masuda, Shinya, Ohue-Kitano, Ryuji, Yamakage, Hajime, Muranaka, Kazuya, Wada, Hiromichi, Kusakabe, Toru, Shimatsu, Akira, Hasegawa, Koji, Satoh-Asahara, Noriko

“…Obesity and diabetes are known risk factors for dementia, and it is speculated that chronic neuroinflammation contributes to this increased risk. Microglia are…”
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CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats by Izumi, Ryota, Kusakabe, Toru, Noguchi, Michio, Iwakura, Hiroshi, Tanaka, Tomohiro, Miyazawa, Takashi, Aotani, Daisuke, Hosoda, Kiminori, Kangawa, Kenji, Nakao, Kazuwa

“…Angiopoietin-like protein (ANGPTL)8 is a liver- and adipocyte-derived protein that controls plasma triglyceride (TG) levels. Most animal studies have used…”
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Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study by Ohara, Tomoyuki, Hata, Jun, Tanaka, Masashi, Honda, Takanori, Yamakage, Hajime, Yoshida, Daigo, Inoue, Takayuki, Hirakawa, Yoichiro, Kusakabe, Toru, Shibata, Mao, Teraoka, Tadashi, Kitazono, Takanari, Kanba, Shigenobu, Satoh‐Asahara, Noriko, Ninomiya, Toshiharu

“…Objective To investigate the association between serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a soluble type of an innate immune…”
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α‐Linolenic acid‐derived metabolites from gut lactic acid bacteria induce differentiation of anti‐inflammatory M2 macrophages through G protein‐coupled receptor 40 by Ohue‐Kitano, Ryuji, Yasuoka, Yumiko, Goto, Tsuyoshi, Kitamura, Nahoko, Park, Si‐Bum, Kishino, Shigenobu, Kimura, Ikuo, Kasubuchi, Mayu, Takahashi, Haruya, Li, Yongjia, Yeh, Yu‐Sheng, Jheng, Huei‐Fen, Iwase, Mari, Tanaka, Masashi, Masuda, Shinya, Inoue, Takayuki, Yamakage, Hajime, Kusakabe, Toru, Tani, Fumito, Shimatsu, Akira, Takahashi, Nobuyuki, Ogawa, Jun, Satoh‐Asahara, Noriko, Kawada, Teruo

“…Among dietary fatty acids with immunologic effects, ω‐3 polyunsaturated fatty acids, such as a‐linolenic acid (ALA), have been considered as factors that…”
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Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2α–ATF4 Pathway in Mouse Microglia by Inoue, Takayuki, Yamakage, Hajime, Tanaka, Masashi, Kusakabe, Toru, Shimatsu, Akira, Satoh-Asahara, Noriko

“…Microglia maintain brain homeostasis and modulate neuroinflammation and are implicated in the pathogenesis of various neurological diseases such as Alzheimer’s…”
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Beneficial Effects of Ipragliflozin on the Renal Function and Serum Uric Acid Levels in Japanese Patients with Type 2 Diabetes: A Randomized, 12-week, Open-label, Active-controlled Trial by Tanaka, Masashi, Yamakage, Hajime, Inoue, Takayuki, Odori, Shinji, Kusakabe, Toru, Shimatsu, Akira, Satoh-Asahara, Noriko

“…Objective To examine the add-on effects, compared to the existing antidiabetes treatment, of the sodium-glucose cotransporter 2 inhibitor ipragliflozin on…”
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Visceral-to-subcutaneous fat ratio is a possible prognostic factor for type 1 endometrial cancer by Wada, Michiko, Yamaguchi, Ken, Yamakage, Hajime, Inoue, Takayuki, Kusakabe, Toru, Abiko, Kaoru, Takakura, Kenji, Konishi, Ikuo, Satoh-Asahara, Noriko

“…Background Associations have been observed between obesity defined by the body mass index (BMI) and the incidence of endometrial cancer. However, the impact of…”
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Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons by Kuwabara, Takashige, Mori, Kiyoshi, Mukoyama, Masashi, Kasahara, Masato, Yokoi, Hideki, Saito, Yoko, Yoshioka, Tetsuro, Ogawa, Yoshihisa, Imamaki, Hirotaka, Kusakabe, Toru, Ebihara, Ken, Omata, Mitsugu, Satoh, Noriko, Sugawara, Akira, Barasch, Jonathan, Nakao, Kazuwa

“…Urinary neutrophil gelatinase-associated lipocalin (Ngal or lipocalin 2) is a very early and sensitive biomarker of kidney injury. Here we determined the…”
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Practice guideline for lipodystrophy syndromes—clinically important diseases of the Japan Endocrine Society (JES) by Tanaka, Tomohiro, Kusakabe, Toru, Ebihara, Ken, Aizawa-Abe, Megumi, Aotani, Daisuke, Yorifuji, Tohru, Satoh, Mari, Ogawa, Yoshihiro, Nakao, Kazuwa

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Prediction of long-term biochemical cure in patients with unilateral primary hyperaldosteronism treated surgically based on the early post-operative plasma aldosterone value by Ishihara, Yuki, Umakoshi, Hironobu, Kaneko, Hiroki, Nanba, Kazutaka, Tsuiki, Mika, Kusakabe, Toru, Satoh-Asahara, Noriko, Yasoda, Akihiro, Tagami, Tetsuya

“…In 2017, the Primary Aldosteronism Surgical Outcome (PASO) investigators proposed consensus criteria for clinical and biochemical outcomes. However, 6 to 12…”
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Effects of dapagliflozin on the serum levels of fibroblast growth factor 21 and myokines and muscle mass in Japanese patients with type 2 diabetes: A randomized, controlled trial by Yamakage, Hajime, Tanaka, Masashi, Inoue, Takayuki, Odori, Shinji, Kusakabe, Toru, Satoh‐Asahara, Noriko

“…Aims/Introduction Our aims were to examine the add‐on effects of a sodium–glucose cotransporter 2 inhibitor, dapagliflozin, compared with existing antidiabetes…”
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A combined index of waist circumference and muscle quality is associated with cardiovascular disease risk factor accumulation in Japanese obese patients: a cross-sectional study by Ikeue, Kentaro, Kusakabe, Toru, Muranaka, Kazuya, Yamakage, Hajime, Inoue, Takayuki, Ishii, Kojiro, Satoh-Asahara, Noriko

“…Purpose To identify obese patients at high risk of cardiovascular disease (CVD) using a combined index of obesity and sarcopenia. Methods In this…”
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Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis by Ebihara, Chihiro, Ebihara, Ken, Aizawa-Abe, Megumi, Mashimo, Tomoji, Tomita, Tsutomu, Zhao, Mingming, Gumbilai, Valentino, Kusakabe, Toru, Yamamoto, Yuji, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Hosoda, Kiminori, Serikawa, Tadao, Nakao, Kazuwa

“…Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital…”
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Seated saline infusion test in predicting subtype diagnosis of primary aldosteronism by Kaneko, Hiroki, Umakoshi, Hironobu, Ishihara, Yuki, Sugawa, Taku, Nanba, Kazutaka, Tsuiki, Mika, Kusakabe, Toru, Satoh‐Asahara, Noriko, Yasoda, Akihiro, Tagami, Tetsuya

“…Context Although saline infusion test is widely used as a confirmatory test for primary aldosteronism (PA), it is reportedly less sensitive in patients in whom…”
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Imaging spectrum of abnormal subcutaneous and visceral fat distribution by Yamamoto, Asako, Kikuchi, Yoshinao, Kusakabe, Toru, Takano, Hideyuki, Sakurai, Keita, Furui, Shigeru, Oba, Hiroshi

“…Adipose tissue plays multiple and complex roles not only in mechanical cushioning and energy storage but also as an important secretory organ that regulates…”
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Comprehensive Profiling of GPCR Expression in Ghrelin-Producing Cells by Koyama, Hiroyuki, Iwakura, Hiroshi, Dote, Katsuko, Bando, Mika, Hosoda, Hiroshi, Ariyasu, Hiroyuki, Kusakabe, Toru, Son, Choel, Hosoda, Kiminori, Akamizu, Takashi, Kangawa, Kenji, Nakao, Kazuwa

“…To determine the comprehensive G protein-coupled receptor (GPCR) expression profile in ghrelin-producing cells and to elucidate the role of GPCR-mediated…”
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Observation of p.R4810K, a Polymorphism of the Mysterin Gene, the Susceptibility Gene for Moyamoya Disease, in Two Female Japanese Diabetic Patients with Familial Partial Lipodystrophy 1 by Iwanishi, Masanori, Azuma, Choka, Tezuka, Yuji, Yamamoto, Yukako, Ito-Kobayashi, Jun, Washiyama, Miki, Kusakabe, Toru, Kikugawa, Shingo

“…Mysterin, which was recently shown to play an important role in maintaining cellular fat storage, has been identified to be the susceptibility gene for…”
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