Search Results - "KUROKAWA, Manabu"

Regulation of Oocyte Apoptosis: A View from Gene Knockout Mice by Kaur, Sandeep, Kurokawa, Manabu

“…Apoptosis is a form of programmed cell death that plays a critical role in cellular homeostasis and development, including in the ovarian reserve. In humans,…”
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Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway by Bang, Scott, Kaur, Sandeep, Kurokawa, Manabu

“…The tumor suppressor p53 and its homologues, p63 and p73, play a pivotal role in the regulation of the DNA damage response, cellular homeostasis, development,…”
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Regulation of MDM2 Stability After DNA Damage by Li, Jiaqi, Kurokawa, Manabu

“…Cells in our body are constantly exposed to various stresses and threats to their genomic integrity. The tumor suppressor protein p53 plays a critical role in…”
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Predicting clinical outcomes of cancer patients with a p53 deficiency gene signature by Schaafsma, Evelien, Takacs, Eric M., Kaur, Sandeep, Cheng, Chao, Kurokawa, Manabu

“…The tumor suppressor p53, encoded by the TP53 gene, is mutated or nullified in nearly 50% of human cancers. It has long been debated whether TP53 mutations can…”
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CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies by Feng, William W., Wilkins, Owen, Bang, Scott, Ung, Matthew, Li, Jiaqi, An, Jennifer, del Genio, Carmen, Canfield, Kaleigh, DiRenzo, James, Wells, Wendy, Gaur, Arti, Robey, R. Brooks, Guo, Jessie Yanxiang, Powles, Ryan L., Sotiriou, Christos, Pusztai, Lajos, Febbraio, Maria, Cheng, Chao, Kinlaw, William B., Kurokawa, Manabu

“…Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer, the role of exogenous FA uptake remains elusive. Here we show…”
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Evidence for macromolecular crowding as a direct apoptotic stimulus by Rana, Priyanka S, Kurokawa, Manabu, Model, Michael A

“…Potassium loss and persistent shrinkage have both been implicated in apoptosis but their relationship and respective roles remain controversial. We approached…”
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Macromolecular Crowding: a Hidden Link Between Cell Volume and Everything Else by Model, Michael A, Hollembeak, Jordan E, Kurokawa, Manabu

“…High density of intracellular macromolecules creates a special condition known as macromolecular crowding (MC). One well-established consequence of MC is that…”
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The Role of CD36 in Cancer Progression and Its Value as a Therapeutic Target by Feng, William W, Zuppe, Hannah T, Kurokawa, Manabu

“…Cluster of differentiation 36 (CD36) is a cell surface scavenger receptor that plays critical roles in many different types of cancer, notably breast, brain,…”
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Inhibition of Apoptosome Formation by Suppression of Hsp90β Phosphorylation in Tyrosine Kinase-Induced Leukemias by Kurokawa, Manabu, Zhao, Chen, Reya, Tannishtha, Kornbluth, Sally

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1 by Pennington, Katie L, McEwan, Colten M, Woods, James, Muir, Colin M, Pramoda Sahankumari, A G, Eastmond, Riley, Balasooriya, Eranga R, Egbert, Christina M, Kaur, Sandeep, Heaton, Tyler, McCormack, Katherine K, Piccolo, Stephen R, Kurokawa, Manabu, Andersen, Joshua L

“…PTOV1 is an oncogenic protein, initially identified in prostate cancer, that promotes proliferation, cell motility, and invasiveness. However, the mechanisms…”
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CD36: a key mediator of resistance to HER2 inhibitors in breast cancer by Feng, William W., Bang, Scott, Kurokawa, Manabu

“…Acquired resistance to anti-HER2 therapy is a significant clinical challenge in breast cancer. We recently discovered that during acquisition of resistance to…”
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Calcium oscillations and mammalian egg activation by Malcuit, Christopher, Kurokawa, Manabu, Fissore, Rafael A.

“…Fertilization in all species studied to date induces an increase in the intracellular concentration of free calcium ions ([Ca2+]i) within the egg. In mammals,…”
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Evading apoptosis in cancer by Fernald, Kaleigh, Kurokawa, Manabu

“…Highlights • Cancer cells employ multiple strategies to block apoptosis. • Cancer cells modulate apoptotic signals at genomic and protein levels. • Agents that…”
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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53 by Kurokawa, Manabu, Kim, Jiyeon, Geradts, Joseph, Matsuura, Kenkyo, Liu, Liu, Ran, Xu, Xia, Wenle, Ribar, Thomas J, Henao, Ricardo, Dewhirst, Mark W, Kim, Wun-Jae, Lucas, Joseph E, Wang, Shaomeng, Spector, Neil L, Kornbluth, Sally

“…In the intrinsic pathway of apoptosis, cell-damaging signals promote the release of cytochrome c from mitochondria, triggering activation of the Apaf-1 and…”
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Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring by Feng, William W., Bang, Scott, Takacs, Eric M., Day, Cora, Crawford, Katherine J., Al-Sheyab, Ruba, Almufarrej, Dara B., Wells, Wendy, Ilchenko, Serguei, Kasumov, Takhar, Kon, Ning, Novak, Colleen M., Gu, Wei, Kurokawa, Manabu

“…Non-alcoholic fatty liver disease (NAFLD) is the most pervasive liver pathology worldwide. Here, we demonstrate that the ubiquitin E3 ligase Huwe1 is vital in…”
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Metabolic Activation of CaMKII by Coenzyme A by McCoy, Francis, Darbandi, Rashid, Lee, Hoi Chang, Bharatham, Kavitha, Moldoveanu, Tudor, Grace, Christy R, Dodd, Keela, Lin, Wenwei, Chen, Si-Ing, Tangallapally, Rajendra P, Kurokawa, Manabu, Lee, Richard E, Shelat, Anang A, Chen, Taosheng, Green, Douglas R, Harris, Robert A, Lin, Sue-Hwa, Fissore, Rafael A, Colbran, Roger J, Nutt, Leta K

“…Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link…”
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Caspases and Kinases in a Death Grip by Kurokawa, Manabu, Kornbluth, Sally

“…The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence…”
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Functional, biochemical, and chromatographic characterization of the complete [Ca 2+] i oscillation-inducing activity of porcine sperm by Kurokawa, Manabu, Sato, Ken-ichi, Wu, Hua, He, Changli, Malcuit, Christopher, Black, Samuel J., Fukami, Kiyoko, Fissore, Rafael A.

“…A cytosolic sperm protein(s), referred to as sperm factor (SF), is delivered into eggs by the sperm during mammalian fertilization to induce repetitive…”
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Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells by Canfield, Kaleigh, Li, Jiaqi, Wilkins, Owen M., Morrison, Meghan M, Ung, Matthew, Wells, Wendy, Williams, Charlotte R., Liby, Karen T, Vullhorst, Detlef, Buonanno, Andres, Hu, Huizhong, Schiff, Rachel, Cook, Rebecca S, Kurokawa, Manabu

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Plasmid-Mediated Resistance to Cephalosporins in Salmonella enterica Serovar Typhi by Morita, Masatomo, Takai, Nobuko, Terajima, Jun, Watanabe, Haruo, Kurokawa, Manabu, Sagara, Hiroko, Ohnishi, Kenji, Izumiya, Hidemasa

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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