Search Results - "KURODA, Ryotaro"

The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection by Kawabata, A, Kinoshita, M, Nishikawa, H, Kuroda, R, Nishida, M, Araki, H, Arizono, N, Oda, Y, Kakehi, K

“…Protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, modulates smooth muscle tone and exocrine secretion in the salivary glands and…”
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Modulation of Capsaicin-Evoked Visceral Pain and Referred Hyperalgesia by Protease-Activated Receptors 1 and 2 by Kawao, Naoyuki, Ikeda, Hisao, Kitano, Tomoko, Kuroda, Ryotaro, Sekiguchi, Fumiko, Kataoka, Kazuo, Kamanaka, Yoshihisa, Kawabata, Atsufumi

“…Protease-activated receptors (PARs) 1 and 2 are expressed in capsaicin-sensitive sensory neurons, being anti- and pro-nociceptive, respectively. Given the…”
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Potent and metabolically stable agonists for protease-activated receptor-2: evaluation of activity in multiple assay systems in vitro and in vivo by Kawabata, Atsufumi, Kanke, Toru, Yonezawa, Daiki, Ishiki, Tsuyoshi, Saka, Masako, Kabeya, Mototsugu, Sekiguchi, Fumiko, Kubo, Satoko, Kuroda, Ryotaro, Iwaki, Masahiro, Katsura, Kousaku, Plevin, Robin

“…To develop potent and metabolically stable agonists for protease-activated receptor-2 (PAR-2), we prepared 2-furoylated (2f) derivatives of native…”
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Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats by Kawabata, Atsufumi, Kawao, Naoyuki, Kuroda, Ryotaro, Tanaka, Atsuko, Itoh, Hideki, Nishikawa, Hiroyuki

“…Protease-activated receptor-2 (PAR-2), a member of the G protein-coupled, seven trans-membrane domain receptor family, is activated by trypsin/tryptase and…”
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Increased vascular permeability by a specific agonist of protease‐activated receptor‐2 in rat hindpaw by Kawabata, Atsufumi, Kuroda, Ryotaro, Minami, Takeshi, Kataoka, Kazuo, Taneda, Mamoru

“…The present study examined the effect of intraplantar (i.pl.) administration of a selective agonist of protease‐activated receptor (PAR)‐2,…”
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Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion by Kawabata, Atsufumi, Kuroda, Ryotaro, Nishida, Minoru, Nagata, Nanae, Sakaguchi, Yuriko, Kawao, Naoyuki, Nishikawa, Hiroyuki, Arizono, Naoki, Kawai, Kenzo

“…Protease-activated receptor-2, a G protein-coupled receptor activated by serine proteases such as trypsin, tryptase and coagulation factors VIIa and Xa,…”
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Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity by Kawabata, Atsufumi, Kubo, Satoko, Ishiki, Tsuyoshi, Kawao, Naoyuki, Sekiguchi, Fumiko, Kuroda, Ryotaro, Hollenberg, Morley D, Kanke, Toru, Saito, Naohiro

“…We characterized the tracheal and bronchial relaxation caused by proteinase-activated receptor-2 (PAR-2) activation in ddY mice and/or in wild-type and…”
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Proteinase‐activated receptor‐2 (PAR‐2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice by Kawabata, Atsufumi, Nishikawa, Hiroyuki, Kuroda, Ryotaro, Kawai, Kenzo, Hollenberg, Morley D

“…Proteinase‐activated receptor‐2 (PAR‐2) is expressed throughout the gastrointestinal tract including the pancreas, and may be involved in digestive functions…”
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Modulation by protease‐activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation by Kawabata, Atsufumi, Kuroda, Ryotaro, Nishikawa, Hiroyuki, Kawai, Kenzo

“…The present study examined effects of agonist enzymes and receptor‐activating peptides for protease‐activated receptors (PARs) on duodenal motility in the rat,…”
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Factor Xa-Evoked Relaxation in Rat Aorta: Involvement of PAR-2 by Kawabata, Atsufumi, Kuroda, Ryotaro, Nakaya, Yumiko, Kawai, Kenzo, Nishikawa, Hiroyuki, Kawao, Naoyuki

“…Protease-activated receptor-2 (PAR-2) and/or effector cell protease receptor-1 (EPR-1) may mediate the direct cellular actions of coagulation factor Xa in some…”
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Activation of Protease-Activated Receptor-2 (PAR-2) Triggers Mucin Secretion in the Rat Sublingual Gland by Kawabata, Atsufumi, Morimoto, Nao, Nishikawa, Hiroyuki, Kuroda, Ryotaro, Oda, Yasuo, Kakehi, Kazuaki

“…Protease-activated receptor-2 (PAR-2) is distributed throughout the gastrointestinal systems. The present study investigated the role for PAR-2 in the rat…”
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Protease‐activated receptor‐2 (PAR‐2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion by Kawao, Naoyuki, Sakaguchi, Yuriko, Tagome, Ai, Kuroda, Ryotaro, Nishida, Shozo, Irimajiri, Kiyohiro, Nishikawa, Hiroyuki, Kawai, Kenzo, Hollenberg, Morley D, Kawabata, Atsufumi

“…Agonists of protease‐activated receptor‐2 (PAR‐2) trigger neurally mediated mucus secretion accompanied by mucosal cytoprotection in the stomach. The present…”
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Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats by Nishikawa, Hiroyuki, Kawai, Kenzo, Nishimura, Sachiyo, Tanaka, Shuichi, Araki, Hiromasa, Al-Ani, Bahjat, Hollenberg, Morley D, Kuroda, Ryotaro, Kawabata, Atsufumi

“…Activation of protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, induces neurally mediated gastric mucus secretion accompanied by…”
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Involvement of EDHF in the hypotension and increased gastric mucosal blood flow caused by PAR‐2 activation in rats by Kawabata, Atsufumi, Nakaya, Yumiko, Kuroda, Ryotaro, Wakisaka, Mariko, Masuko, Takashi, Nishikawa, Hiroyuki, Kawai, Kenzo

“…Agonists for protease‐activated receptor‐2 (PAR‐2) cause hypotension and an increase in gastric mucosal blood flow (GMBF) in vivo. We thus studied the…”
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The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats by Kawabata, Atsufumi, Kawao, Naoyuki, Kuroda, Ryotaro, Tanaka, Atsuko, Shimada, Chiho

“…We examined if thrombin or a receptor-activating peptide for protease-activated receptor-1 (PAR-1), a thrombin receptor, could modulate nociception at…”
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Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms by Kawabata, Atsufumi, Nakaya, Yumiko, Ishiki, Tsuyoshi, Kubo, Satoko, Kuroda, Ryotaro, Sekiguchi, Fumiko, Kawao, Naoyuki, Nishikawa, Hiroyuki, Kawai, Kenzo

“…Receptor-activating peptides for protease-activated receptors (PARs) 1 or 2 enhance gastric mucosal blood flow (GMBF) and protect against gastric mucosal…”
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Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease‐activated receptors (PARs): a novel role for PAR‐4 as opposed to PAR‐1 by Kawabata, Atsufumi, Kuroda, Ryotaro, Kuroki, Naoko, Nishikawa, Hiroyuki, Kawai, Kenzo

“…Since protease‐activated receptors (PARs) are distributed throughout the gastrointestinal tract, we investigated the role of PARs in modulation of the motility…”
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Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats by Kawabata, Atsufumi, Itoh, Hideki, Kawao, Naoyuki, Kuroda, Ryotaro, Sekiguchi, Fumiko, Masuko, Takashi, Iwata, Koichi, Ogawa, Akiko

“…To clarify involvement of protease-activated receptor-2 (PAR-2) in parotid pain, we examined whether PAR-2 activation in the parotid gland could activate…”
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Capsazepine Partially Inhibits Neurally Mediated Gastric Mucus Secretion Following Activation Of Protease-Activated Receptor 2 by Kawabata, Atsufumi, Kinoshita, Mitsuhiro, Kuroda, Ryotaro, Kakehi, Kazuaki

“…SUMMARY 1. Protease‐activated receptor 2 (PAR2), present in capsaicin‐sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2…”
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Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats by Kawabata, Atsufumi, Kawao, Naoyuki, Kuroda, Ryotaro, Itoh, Hideki, Nishikawa, Hiroyuki

“…Protease-activated receptor-2 (PAR-2) in the sensory neurons may be involved in nociceptive processing. We attempted to detect and characterize specific…”
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