Search Results - "KURIYAN, John"

The origin of protein interactions and allostery in colocalization by Kuriyan, John, Eisenberg, David

“…Two fundamental principles can account for how regulated networks of interacting proteins originated in cells. These are the law of mass action, which holds…”
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A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor by Kovacs, Erika, Zorn, Julie Anne, Huang, Yongjian, Barros, Tiago, Kuriyan, John

“…The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a critical role in the pathogenesis of many cancers. The structure of…”
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Molecular mechanisms in signal transduction at the membrane by Kuriyan, John, Groves, Jay T

“…Signal transduction originates at the membrane, where the clustering of signaling proteins is a key step in transmitting a message. Membranes are difficult to…”
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Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane by Karandur, Deepti, Nawrotek, Agata, Kuriyan, John, Cherfils, Jacqueline

“…Lipidated small GTPases and their regulators need to bind to membranes to propagate actions in the cell, but an integrated understanding of how the lipid…”
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A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS by Huang, William Y C, Alvarez, Steven, Kondo, Yasushi, Lee, Young Kwang, Chung, Jean K, Lam, Hiu Yue Monatrice, Biswas, Kabir H, Kuriyan, John, Groves, Jay T

“…The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) is a key Ras activator that is autoinhibited in the cytosol and activates upon membrane…”
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Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases by Kondo, Yasushi, Ognjenović, Jana, Banerjee, Saikat, Karandur, Deepti, Merk, Alan, Kulhanek, Kayla, Wong, Kathryn, Roose, Jeroen P, Subramaniam, Sriram, Kuriyan, John

“…Raf kinases are important cancer drug targets. Paradoxically, many B-Raf inhibitors induce the activation of Raf kinases. Cryo-electron microscopy structural…”
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An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor by Zhang, Xuewu, Gureasko, Jodi, Shen, Kui, Cole, Philip A., Kuriyan, John

“…The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon dimerization has eluded definition. We find that the EGFR kinase domain…”
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Structural basis and regulation of the reductive stress response by Manford, Andrew G., Mena, Elijah L., Shih, Karen Y., Gee, Christine L., McMinimy, Rachael, Martínez-González, Brenda, Sherriff, Rumi, Lew, Brandon, Zoltek, Madeline, Rodríguez-Pérez, Fernando, Woldesenbet, Makda, Kuriyan, John, Rape, Michael

“…Although oxidative phosphorylation is best known for producing ATP, it also yields reactive oxygen species (ROS) as invariant byproducts. Depletion of ROS…”
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Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3 by Jura, Natalia, Shan, Yibing, Cao, Xiaoxian, Shaw, David E, Kuriyan, John

“…The kinase domain of human epidermal growth factor receptor (HER) 3/ErbB3, a member of the EGF receptor (EGFR) family, lacks several residues that are critical…”
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The Conformational Plasticity of Protein Kinases by Huse, Morgan, Kuriyan, John

“…Protein kinases operate in a large number of distinct signaling pathways, where the tight regulation of their catalytic activity is crucial to the development…”
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Architecture and Membrane Interactions of the EGF Receptor by Arkhipov, Anton, Shan, Yibing, Das, Rahul, Endres, Nicholas F., Eastwood, Michael P., Wemmer, David E., Kuriyan, John, Shaw, David E.

“…Dimerization-driven activation of the intracellular kinase domains of the epidermal growth factor receptor (EGFR) upon extracellular ligand binding is crucial…”
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Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis by Bajaj, Teena, Kuriyan, John, Gee, Christine L

“…Genomic analysis of the unicellular choanoflagellate, Monosiga brevicollis (MB), revealed the remarkable presence of cell signaling and adhesion protein…”
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Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction by Simonetta, Kyle R., Taygerly, Joshua, Boyle, Kathleen, Basham, Stephen E., Padovani, Chris, Lou, Yan, Cummins, Thomas J., Yung, Stephanie L., von Soly, Szerenke Kiss, Kayser, Frank, Kuriyan, John, Rape, Michael, Cardozo, Mario, Gallop, Mark A., Bence, Neil F., Barsanti, Paul A., Saha, Anjanabha

“…Protein–protein interactions (PPIs) governing the recognition of substrates by E3 ubiquitin ligases are critical to cellular function. There is significant…”
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How a DNA Polymerase Clamp Loader Opens a Sliding Clamp by Kelch, Brian A., Makino, Debora L., O'Donnell, Mike, Kuriyan, John

“…Processive chromosomal replication relies on sliding DNA clamps, which are loaded onto DNA by pentameric clamp loader complexes belonging to the AAA+ family of…”
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Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites by Cantor, Aaron J., Shah, Neel H., Kuriyan, John

“…Upon activation, the epidermal growth factor receptor (EGFR) phosphorylates tyrosine residues in its cytoplasmic tail, which triggers the binding of Src…”
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Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor by Endres, Nicholas F., Das, Rahul, Smith, Adam W., Arkhipov, Anton, Kovacs, Erika, Huang, Yongjian, Pelton, Jeffrey G., Shan, Yibing, Shaw, David E., Wemmer, David E., Groves, Jay T., Kuriyan, John

“…How the epidermal growth factor receptor (EGFR) activates is incompletely understood. The intracellular portion of the receptor is intrinsically active in…”
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A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor by Huang, Yongjian, Ognjenovic, Jana, Karandur, Deepti, Miller, Kate, Merk, Alan, Subramaniam, Sriram, Kuriyan, John

“…The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that couples the binding of extracellular ligands, such as EGF and transforming…”
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Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases by Endres, Nicholas F., Barros, Tiago, Cantor, Aaron J., Kuriyan, John

“…•Activation of receptor tyrosine kinases involves both dimerization and allostery.•Their catalytic domains are flexible and adopt multiple inactive…”
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CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks by Cofsky, Joshua C, Karandur, Deepti, Huang, Carolyn J, Witte, Isaac P, Kuriyan, John, Doudna, Jennifer A

“…Type V CRISPR-Cas interference proteins use a single RuvC active site to make RNA-guided breaks in double-stranded DNA substrates, an activity essential for…”
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Activation of tyrosine kinases by mutation of the gatekeeper threonine by Kuriyan, John, Daley, George Q, Azam, Mohammad, Seeliger, Markus A, Gray, Nathanael S

“…Substitution of the active site gatekeeper residue in the BCR-ABL oncoprotein and related kinases is a common mechanism of imanitib resistance but has also…”
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