Search Results - "KURIHARA, Yuji"

Nogo receptor antagonist LOTUS exerts suppression on axonal growth‐inhibiting receptor PIR‐B by Kurihara, Yuji, Takai, Toshiyuki, Takei, Kohtaro

“…Damaged axons in the adult mammalian central nervous system have a restricted regenerative capacity mainly because of Nogo protein, which is a major…”
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Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS by Kurihara, Yuji, Saito, Yu, Takei, Kohtaro

“…Highlights • Overexpression of LOTUS inhibits CSPG-induced growth cone collapse. • Loss of LOTUS causes growth cone collapse induced by CSPGs. • Overexpression…”
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LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB by Kawaguchi, Yuki, Matsubayashi, Junpei, Kawakami, Yutaka, Nishida, Ryohei, Kurihara, Yuji, Takei, Kohtaro

“…Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide but has no effective treatment. Amyloid beta (Aβ) protein, a primary risk…”
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The soluble form of LOTUS inhibits Nogo receptor type 1-mediated signaling induced by B lymphocyte stimulator and chondroitin sulfate proteoglycans by Kawakami, Yutaka, Saito, Yu, Nakagawa, Ryota, Kurihara, Yuji, Takei, Kohtaro

“…•Lateral olfactory tract usher substance (LOTUS) is an antagonist of NgR1.•The soluble form of LOTUS (s-LOTUS) suppresses BLyS-induced NgR1 signal.•LOTUS also…”
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LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice by Takase, Hajime, Kurihara, Yuji, Yokoyama, Taka-Akira, Kawahara, Nobutaka, Takei, Kohtaro

“…Nogo receptor-1 (NgR1) and its ligands inhibit neuronal plasticity and limit functional recovery after brain damage such as ischemic stroke. We have previously…”
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Pharmacokinetics and Safety of Pemafibrate in Patients with both Dyslipidemia and Severe Renal Impairment: A Phase 4 Study by Ishibashi, Shun, Arai, Hidenori, Yokote, Koutaro, Araki, Eiichi, Watanabe, Mao, Nakanishi, Michiko, Makinose, Yuichi, Suganami, Hideki, Kurihara, Yuji, Yamashita, Shizuya

“…Aims: Per the package insert, pemafibrate was contraindicated for use in patients with severe renal impairment despite its biliary excretion. To validate this,…”
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Axonal regeneration and functional recovery driven by endogenous Nogo receptor antagonist LOTUS in a rat model of unilateral pyramidotomy by Ueno, Ryu, Takase, Hajime, Suenaga, Jun, Kishimoto, Masao, Kurihara, Yuji, Takei, Kohtaro, Kawahara, Nobutaka, Yamamoto, Tetsuya

“…The adult mammalian central nervous system (CNS) rarely recovers from injury. Myelin fragments contain axonal growth inhibitors that limit axonal regeneration,…”
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PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain by Kurihara, Yuji, Mitsunari, Kotone, Mukae, Nagi, Shoji, Hirotaka, Miyakawa, Tsuyoshi, Shirane, Michiko

“…Although dyslipidemia in the brain has been implicated in neurodegenerative disorders, the molecular mechanisms underlying its pathogenesis have been largely…”
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Laparoscopic Repair Using Self-Fixating Mesh in an Adult Patient with a Sciatic Hernia and Irreducible Small Bowel: A Case Report and Literature Review by Chihara, Naoto, Taniai, Nobuhiko, Nakata, Ryosuke, Yokoyama, Yasuyuki, Mishima, Keisuke, Yamagiwa, Ryo, Matsutani, Takeshi, Kurihara, Yuji, Nomura, Tsutomu, Yoshida, Hiroshi

“…Sciatic hernia is a rare type of pelvic floor hernia. The herniated tissue can include the ureter, small and large bowel, and ovary, among other tissues. Only…”
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Nogo Receptor Antagonist LOTUS Promotes Neurite Outgrowth through Its Interaction with Teneurin-4 by Kurihara, Yuji, Kawaguchi, Yuki, Ohta, Yuki, Kawasaki, Nana, Fujita, Yuki, Takei, Kohtaro

“…Neurite outgrowth is a crucial process for organizing neuronal circuits in neuronal development and regeneration after injury. Regenerative failure in the…”
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Safety and effectiveness of tofogliflozin in Japanese patients with type 2 diabetes mellitus treated in real‐world clinical practice: Results of a 36‐month post‐marketing surveillance study (J‐STEP/LT) by Utsunomiya, Kazunori, Koshida, Ryusuke, Kakiuchi, Seigo, Senda, Masayuki, Fujii, Shoko, Kurihara, Yuji, Gunji, Ryoji, Kaku, Kohei

“…Aims/Introduction Tofogliflozin is a sodium–glucose cotransporter 2 (SGLT2) inhibitor that lowers plasma glucose levels by enhancing urinary glucose excretion…”
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LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand by Kurihara, Yuji, Iketani, Masumi, Ito, Hiromu, Nishiyama, Kuniyuki, Sakakibara, Yusuke, Goshima, Yoshio, Takei, Kohtaro

“…Axon growth inhibitors such as Nogo proteins, myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp), and B lymphocyte stimulator…”
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Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS by Hirokawa, Tomoko, Zou, Yixiao, Kurihara, Yuji, Jiang, Zhaoxin, Sakakibara, Yusuke, Ito, Hiromu, Funakoshi, Kengo, Kawahara, Nobutaka, Goshima, Yoshio, Strittmatter, Stephen M., Takei, Kohtaro

“…Axonal regeneration in the adult mammalian central nervous system is limited in part by the non-permissive environment, including axonal growth inhibitors such…”
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Safety and effectiveness of tofogliflozin in Japanese patients with type 2 diabetes mellitus: Results of 24‐month interim analysis of a long‐term post‐marketing study (J‐STEP/LT) by Utsunomiya, Kazunori, Kakiuchi, Seigo, Senda, Masayuki, Fujii, Shoko, Kurihara, Yuji, Gunji, Ryoji, Koshida, Ryusuke, Kameda, Hiroyuki, Tamura, Masahiro, Kaku, Kohei

“…Aims/Introduction Tofogliflozin is a potent and highly selective sodium–glucose cotransporter 2 inhibitor, and is currently used to treat patients with type 2…”
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Cartilage Acidic Protein—1B (LOTUS), an Endogenous Nogo Receptor Antagonist for Axon Tract Formation by Sato, Yasufumi, Iketani, Masumi, Kurihara, Yuji, Yamaguchi, Megumi, Yamashita, Naoya, Nakamura, Fumio, Arie, Yuko, Kawasaki, Takahiko, Hirata, Tatsumi, Abe, Takaya, Kiyonari, Hiroshi, Strittmatter, Stephen M., Goshima, Yoshio, Takei, Kohtaro

“…Neural circuitry formation depends on the molecular control of axonal projection during development. By screening with fluorophore-assisted light inactivation…”
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Long‐term safety and efficacy of the sodium–glucose cotransporter 2 inhibitor, tofogliflozin, added on glucagon‐like peptide‐1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52‐week open‐label, multicenter, post‐marketing clinical study by Terauchi, Yasuo, Fujiwara, Hisataka, Kurihara, Yuji, Suganami, Hideki, Tamura, Masahiro, Senda, Masayuki, Gunji, Ryoji, Kaku, Kohei

“…Aims/Introduction Tofogliflozin is a potent and highly selective sodium–glucose cotransporter 2 inhibitor that is currently used to treat patients with type 2…”
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Safety and efficacy of tofogliflozin in Japanese patients with type 2 diabetes mellitus in real‐world clinical practice: Results of 3‐month interim analysis of a long‐term post‐marketing surveillance study (J‐STEP/LT) by Utsunomiya, Kazunori, Senda, Masayuki, Kakiuchi, Seigo, Kameda, Hiroyuki, Tamura, Masahiro, Kurihara, Yuji, Gunji, Ryoji, Fujii, Shoko, Fujiwara, Hisataka, Kaku, Kohei

“…Aims/Introduction The present study analysis was carried out to evaluate the safety and efficacy of tofogliflozin, a sodium–glucose cotransporter 2 inhibitor,…”
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Safety and effectiveness of tofogliflozin in Japanese patients with type 2 diabetes mellitus in real‐world practice: Results of 12‐month interim analysis of a long‐term post‐marketing surveillance study (J‐STEP/LT) by Utsunomiya, Kazunori, Senda, Masayuki, Kakiuchi, Seigo, Kameda, Hiroyuki, Tamura, Masahiro, Kurihara, Yuji, Gunji, Ryoji, Fujii, Shoko, Kaku, Kohei

“…Aims/Introduction Due to the paucity of tofogliflozin data, we assessed the safety and effectiveness of tofogliflozin among Japanese patients with type 2…”
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Changes in maxillary dental arch morphology after implant treatment in the alveolar cleft region by Ahn, Kilwoo, Sato, Hitoshi, Kurihara, Yuji, Ogura, Hiroshi, Shirota, Tatsuo

“…Background Few reports have examined dental arch morphology (DAM) after dental implant placement in cleft patients and its actual state is unclear. Objective…”
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Huge esophageal gastrointestinal stromal tumor successfully resected under mediastino-laparoscopic transhiatal esophagectomy: a case report by Mishima, Keisuke, Matsutani, Takeshi, Yamagiwa, Ryo, Hanawa, Hidetsugu, Kurihara, Yuji, Motoda, Norio, Taniai, Nobuhiko, Yoshida, Hiroshi

“…Background Esophageal gastrointestinal stromal tumors (E-GISTs) are often diagnosed early due to complaints such as dysphagia and are rarely found to be huge…”
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