Search Results - "KURAMOTO, Kazuya"

The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats by Honda, Yohei, Kosugi, Keiji, Fuchikami, Chiaki, Kuramoto, Kazuya, Numakura, Yuki, Kuwano, Keiichi

“…Pulmonary arterial hypertension (PAH) is a lethal disease characterized by a progressive increase in pulmonary artery pressure due to an increase in vessel…”
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A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries by Fuchikami, Chiaki, Murakami, Kohji, Tajima, Koyuki, Homan, Junko, Kosugi, Keiji, Kuramoto, Kazuya, Oka, Michiko, Kuwano, Keiichi

“…Selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N- (methylsulfonyl)acetamide]) is a novel, orally available non-prostanoid…”
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Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons by Kuramoto, Kazuya, Negishi, Manabu, Katoh, Hironori

“…Rho family small GTPases are key regulators of morphological changes in neurons. Cdc42, one of the most characterized members of the Rho family of proteins, is…”
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Antiproliferative effect of selexipag active metabolite MRE‐269 on pulmonary arterial smooth muscle cells from patients with chronic thromboembolic pulmonary hypertension by Kuramoto, Kazuya, Ogawa, Aiko, Kiyama, Kazuko, Matsubara, Hiromi, Ohno, Yuji, Fuchikami, Chiaki, Hayashi, Kyota, Kosugi, Keiji, Kuwano, Keiichi

“…Chronic thromboembolic pulmonary hypertension (CTEPH) is a group 4 pulmonary hypertension (PH) characterized by nonresolving thromboembolism in the central…”
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FHIT , a Novel Modifier Gene in Pulmonary Arterial Hypertension by Dannewitz Prosseda, Svenja, Tian, Xuefei, Kuramoto, Kazuya, Boehm, Mario, Sudheendra, Deepti, Miyagawa, Kazuya, Zhang, Fan, Solow-Cordero, David, Saldivar, Joshua C., Austin, Eric D., Loyd, James E., Wheeler, Lisa, Andruska, Adam, Donato, Michele, Wang, Lingli, Huebner, Kay, Metzger, Ross J., Khatri, Purvesh, Spiekerkoetter, Edda

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The role of Dock family Rho-GEFs in dendrite morphogenesis by Katoh, Hironori, Ueda, Shuhei, Kuramoto, Kazuya, Fujimoto, Satoshi, Negishi, Manabu

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The selective PGI.sub.2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats by Honda, Yohei, Kosugi, Keiji, Fuchikami, Chiaki, Kuramoto, Kazuya, Numakura, Yuki, Kuwano, Keiichi

“…Pulmonary arterial hypertension (PAH) is a lethal disease characterized by a progressive increase in pulmonary artery pressure due to an increase in vessel…”
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Improving Right Ventricular Function by Increasing BMP Signaling with FK506 by Boehm, Mario, Tian, Xuefei, Ali, Md Khadem, Mao, Yuqiang, Ichimura, Kenzo, Zhao, Mingming, Kuramoto, Kazuya, Dannewitz Prosseda, Svenja, Fajardo, Giovanni, Dufva, Melanie J, Qin, Xulei, Kheyfets, Vitaly O, Bernstein, Daniel, Reddy, Sushma, Metzger, Ross J, Zamanian, Roham T, Haddad, Francois, Spiekerkoetter, Edda

“…Right ventricular (RV) function is the predominant determinant of survival in patients with pulmonary arterial hypertension (PAH). In preclinical models,…”
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FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension by Dannewitz Prosseda, Svenja, Tian, Xuefei, Kuramoto, Kazuya, Boehm, Mario, Sudheendra, Deepti, Miyagawa, Kazuya, Zhang, Fan, Solow-Cordero, David, Saldivar, Joshua C, Austin, Eric D, Loyd, James E, Wheeler, Lisa, Andruska, Adam, Donato, Michele, Wang, Lingli, Huebner, Kay, Metzger, Ross J, Khatri, Purvesh, Spiekerkoetter, Edda

“…Pulmonary arterial hypertension (PAH) is characterized by progressive narrowing of pulmonary arteries, resulting in right heart failure and death. BMPR2 (bone…”
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NS-018 reduces myeloma cell proliferation and suppresses osteolysis through inhibition of the JAK2 and Src signaling pathways by Honda, Ayumi, Kuramoto, Kazuya, Niwa, Tomoko, Naito, Haruna

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Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding by Boehm, Mario, Tian, Xuefei, Mao, Yuqiang, Ichimura, Kenzo, Dufva, Melanie J, Ali, Khadem, Dannewitz Prosseda, Svenja, Shi, Yiwei, Kuramoto, Kazuya, Reddy, Sushma, Kheyfets, Vitaly O, Metzger, Ross J, Spiekerkoetter, Edda

“…Abstract Aims The temporal sequence of events underlying functional right ventricular (RV) recovery after improvement of pulmonary hypertension-associated…”
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Antiproliferative and Antitumor Effects of Azacitidine Against the Human Myelodysplastic Syndrome Cell Line SKM-1 by KIMURA, Sachie, KURAMOTO, Kazuya, HOMAN, Junko, NARUOKA, Haruna, EGO, Takeshi, NOGAWA, Masaki, SUGAHARA, Seishi, NAITO, Haruna

“…The myelodysplastic syndromes (MDS) are a group of stem cell disorders characterized by dysplasia of one or more hematopoietic cell lineages and a risk of…”
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Dual Inhibition of the STAT3 and Src Pathways by NS-018, a JAK2 and Src-Family Kinase Inhibitor, Reduces Myeloma Cell Proliferation and Adhesion and Suppresses Osteoclast Formation by Kuramoto, Kazuya, Kodama, Ayumi, Homan, Junko, Nakaya, Yohei, Kitamura, Toshio, Naito, Haruna

“…Abstract 2900 Multiple myeloma (MM) is a clonal B-cell malignancy characterized by the accumulation of malignant plasma cells in the bone marrow, and it…”
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The Cdc42 activator Zizimin1/Dock9 regulates dendritic development in hippocampal neurons by Kuramoto, Kazuya, Negishi, Manabu, Katoh, Hironori

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