Inhibitory Effect of TJN-101 ((+)-(6S,7S,R-Biar)-5,6,7,8-Tetrahydro-1,2,3,12-Tetramethoxy-6,7-Dimethyl-10,11-Methylenedioxy-6-Dibenzo[a,c]cyclooctenol) on Immunologically Induced Liver Injuries

TJN-101, which is a lignan component isolated from schisandra fruits, inhibits hepatotoxic chemicals-induced liver injuries. In this study, effects of TJN-101 on immunologically induced liver injuries were investigated in vivo and in vitro. When a small dose of lipopolysaccharide was injected into m...

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Bibliographic Details
Published in:	Japanese journal of pharmacology Vol. 44; no. 2; pp. 179 - 185
Main Authors:	KURA, Yasufumi OH, MIZOGUCHI, Yasuhiro, SAKAGAMI, Yoshihide, KOBAYASHI, Kenzo, YAMAMOTO, Sukeo, MORISAWA, Seiji, TAKEDA, Shigefumi, ABURADA, Masaki
Format:	Journal Article
Language:	English
Published:	Kyoto The Japanese Pharmacological Society 1987 Japanese Pharmacological Society
Subjects:	Alanine Transaminase - blood Animals Antibody-Dependent Cell Cytotoxicity - drug effects Aspartate Aminotransferases - blood Biological and medical sciences Cyclooctanes Digestive system Dioxoles Guinea Pigs Lignans Lipopolysaccharides - antagonists & inhibitors Liver Diseases - drug therapy Liver Diseases - immunology Liver Diseases - pathology Macrophage Activation - drug effects Male Medical sciences Mice Mice, Inbred BALB C Pharmacology. Drug treatments Polycyclic Compounds - pharmacology Proteins - metabolism Immunopathology Mortality Rodentia Hepatobiliary disease In vitro Necrosis Prevention In vivo Vertebrata Chemotherapy Liver failure Mammalia Mouse Animal
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Summary:	TJN-101, which is a lignan component isolated from schisandra fruits, inhibits hepatotoxic chemicals-induced liver injuries. In this study, effects of TJN-101 on immunologically induced liver injuries were investigated in vivo and in vitro. When a small dose of lipopolysaccharide was injected into mice previously injected with heat-killed Propionibacterium acnes, most of the animals died with acute hepatic failure which was produced by cytotoxic factors from activated adherent cells, and liver cells were injuried by antibody-dependent cell-mediated cytotoxic (ADCC) reaction or activated macrophages in vitro. TJN-101 reduced the mortality of the mice with acute hepatic failure dose-dependently. Histologically, necrosis was supressed by the treatment of TJN-101, but infiltration of nonspecific inflammatory cells was not. TJN-101 inhibited the isolated liver cell injuries induced by ADCC reaction or activated macrophages in vitro. These results suggest that TJN-101 can be markedly protective against immunological liver injuries.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.44.179