Search Results - "KUPPEVELT, Toin H. Van"

Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis by Stachtea, Xanthi N, Tykesson, Emil, van Kuppevelt, Toin H, Feinstein, Ricardo, Malmström, Anders, Reijmers, Rogier M, Maccarana, Marco

“…The epimerization of glucuronic acid into iduronic acid adds structural variability to chondroitin/dermatan sulfate polysaccharides. Iduronic acid-containing…”
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Directing collagen fibers using counter-rotating cone extrusion by Hoogenkamp, Henk R., Bakker, Gert-Jan, Wolf, Louis, Suurs, Patricia, Dunnewind, Bertus, Barbut, Shai, Friedl, Peter, van Kuppevelt, Toin H., Daamen, Willeke F.

“…[Display omitted] The bio-inspired engineering of tissue equivalents should take into account anisotropic morphology and the mechanical properties of the…”
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Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions by Kalus, Ina, Rohn, Susanne, Puvirajesinghe, Tania M, Guimond, Scott E, Eyckerman-Kölln, Pieter J, Ten Dam, Gerdy, van Kuppevelt, Toin H, Turnbull, Jeremy E, Dierks, Thomas

“…Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of…”
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Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling by Takashima, Yasutoshi, Keino-Masu, Kazuko, Yashiro, Hiroshi, Hara, Satoshi, Suzuki, Tomo, van Kuppevelt, Toin H, Masu, Masayuki, Nagata, Michio

“…Glomerular integrity and functions are maintained by growth factor signaling. Heparan sulfate, the major component of glomerular extracellular matrixes,…”
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Low-GDP, pH-neutral solutions preserve peritoneal endothelial glycocalyx during long-term peritoneal dialysis by Sugiyama, Naoya, Tawada, Mitsuhiro, Sun, Ting, Suzuki, Yasuhiro, Kinashi, Hiroshi, Yamaguchi, Makoto, Katsuno, Takayuki, Aten, Jan, Vlahu, Carmen A., van Kuppevelt, Toin H., Takei, Yoshifumi, Ishimoto, Takuji, Maruyama, Shoichi, Mizuno, Masashi, Ito, Yasuhiko

“…Background During peritoneal dialysis (PD), solute transport and ultrafiltration are mainly achieved by the peritoneal blood vasculature. Glycocalyx lies on…”
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Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity by Christianson, Helena C., Svensson, Katrin J., van Kuppevelt, Toin H., Li, Jin-Ping, Belting, Mattias

“…Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic acids has recently been implicated in the development of cancer…”
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Chemotherapeutic drug delivery by tumoral extracellular matrix targeting by Raavé, René, van Kuppevelt, Toin H., Daamen, Willeke F.

“…Systemic chemotherapy is a primary strategy in the treatment of cancer, but comes with a number of limitations such as toxicity and unfavorable…”
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Dermatan Sulfate Is Involved in the Tumorigenic Properties of Esophagus Squamous Cell Carcinoma by THELIN, Martin A, SVENSSON, Katrin J, BELTING, Mattias, MACCARANA, Marco, MALMSTRÖM, Anders, XIAOFENG SHI, BAGHER, Mariam, AXELSSON, Jakob, ISINGER-EKSTRAND, Anna, KUPPEVELT, Toin H. Van, JOHANSSON, Jan, NILBERT, Mef, ZAIA, Joseph

“…Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion, and metastasis…”
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Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity by Lamanna, William C, Baldwin, Rebecca J, Padva, Michael, Kalus, Ina, Ten Dam, Gerdy, van Kuppevelt, Toin H, Gallagher, John T, von Figura, Kurt, Dierks, Thomas, Merry, Catherine L R

“…HS (heparan sulfate) is essential for normal embryonic development. This requirement is due to the obligatory role for HS in the signalling pathways of many…”
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Iduronic acid in chondroitin/dermatan sulfate affects directional migration of aortic smooth muscle cells by Bartolini, Barbara, Thelin, Martin A, Svensson, Lena, Ghiselli, Giancarlo, van Kuppevelt, Toin H, Malmström, Anders, Maccarana, Marco

“…Aortic smooth muscle cells produce chondroitin/dermatan sulfate (CS/DS) proteoglycans that regulate extracellular matrix organization and cell behavior in…”
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A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands by Armistead, Jennifer S, Wilson, Iain B H, van Kuppevelt, Toin H, Dinglasan, Rhoel R

“…HS (heparan sulfate) has been shown to be an important mediator of Plasmodium sporozoite homing and invasion of the liver, but the role of this…”
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Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology by Lensen, Joost F M, van der Vlag, Johan, Versteeg, Elly M M, Wetzels, Jack F M, van den Heuvel, Lambert P W J, Berden, Jo H M, van Kuppevelt, Toin H, Rops, Angelique L W M M

“…Dermatan sulfate (DS), also known as chondroitin sulfate (CS)-B, is a member of the linear polysaccharides called glycosaminoglycans (GAGs). The expression of…”
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Evaluation and Refinement of Sample Preparation Methods for Extracellular Matrix Proteome Coverage by McCabe, Maxwell C., Schmitt, Lauren R., Hill, Ryan C., Dzieciatkowska, Monika, Maslanka, Mark, Daamen, Willeke F., van Kuppevelt, Toin H., Hof, Danique J., Hansen, Kirk C.

“…The extracellular matrix is a key component of tissues, yet it is underrepresented in proteomic datasets. Identification and evaluation of proteins in the…”
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Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx by Garsen, Marjolein, Lenoir, Olivia, Rops, Angelique L W M M, Dijkman, Henry B, Willemsen, Brigith, van Kuppevelt, Toin H, Rabelink, Ton J, Berden, Jo H M, Tharaux, Pierre-Louis, van der Vlag, Johan

“…Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Endothelin receptor antagonists have emerged as a novel treatment for DN, but the…”
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Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma by Cerezo-Magaña, Myriam, Christianson, Helena C, van Kuppevelt, Toin H, Forsberg-Nilsson, Karin, Belting, Mattias

“…As an adaptive response to hypoxic stress, aggressive tumors rewire their metabolic phenotype into increased malignant behavior through extracellular lipid…”
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Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis by Smeets, Bart, Kuppe, Christoph, Sicking, Eva-Maria, Fuss, Astrid, Jirak, Peggy, van Kuppevelt, Toin H, Endlich, Karlhans, Wetzels, Jack F M, Gröne, Hermann-Josef, Floege, Jürgen, Moeller, Marcus J

“…The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or…”
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Interactions between Skeletal Muscle Myoblasts and their Extracellular Matrix Revealed by a Serum Free Culture System by Chaturvedi, Vishal, Dye, Danielle E, Kinnear, Beverley F, van Kuppevelt, Toin H, Grounds, Miranda D, Coombe, Deirdre R

“…Decellularisation of skeletal muscle provides a system to study the interactions of myoblasts with muscle extracellular matrix (ECM). This study describes the…”
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CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis by Eymael, Jennifer, Sharma, Shagun, Loeven, Markus A, Wetzels, Jack F, Mooren, Fieke, Florquin, Sandrine, Deegens, Jeroen K, Willemsen, Brigith K, Sharma, Vikram, van Kuppevelt, Toin H, Bakker, Marinka A, Ostendorf, Tammo, Moeller, Marcus J, Dijkman, Henry B, Smeets, Bart, van der Vlag, Johan

“…A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and…”
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Membrane permeation of arginine-rich cell-penetrating peptides independent of transmembrane potential as a function of lipid composition and membrane fluidity by Wallbrecher, Rike, Ackels, Tobias, Olea, R. Alis, Klein, Marco J., Caillon, Lucie, Schiller, Jürgen, Bovée-Geurts, Petra H., van Kuppevelt, Toin H., Ulrich, Anne S., Spehr, Marc, Adjobo-Hermans, Merel J.W., Brock, Roland

“…Cell-penetrating peptides (CPPs) are prominent delivery vehicles to confer cellular entry of (bio-) macromolecules. Internalization efficiency and uptake…”
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Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis by Kuppe, Christoph, Gröne, Hermann-Josef, Ostendorf, Tammo, van Kuppevelt, Toin H, Boor, Peter, Floege, Jürgen, Smeets, Bart, Moeller, Marcus J

“…Parietal epithelial cells (PECs) are involved in the development of sclerotic lesions in primary focal and segmental glomerulosclerosis (FSGS). Here, the role…”
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