Search Results - "KUNNE, Cindy"

Complementary Functions of the Flippase ATP8B1 and the Floppase ABCB4 in Maintaining Canalicular Membrane Integrity by Groen, Annemiek, Romero, Marta Rodriguez, Kunne, Cindy, Hoosdally, Sarah J, Dixon, Peter H, Wooding, Carol, Williamson, Catherine, Seppen, Jurgen, van den Oever, Karin, Mok, Kam S, Paulusma, Coen C, Linton, Kenneth J, Oude Elferink, Ronald P.J

“…Background & Aims Progressive familial intrahepatic cholestasis can be caused by mutations in ABCB4 or ATP8B1; each encodes a protein that translocates…”
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Direct Intestinal Cholesterol Secretion Contributes Significantly to Total Fecal Neutral Sterol Excretion in Mice by van der Velde, Astrid E, Vrins, Carlos L.J, van den Oever, Karin, Kunne, Cindy, Oude Elferink, Ronald P.J, Kuipers, Folkert, Groen, Albert K

“…Background & Aims: Hepatobiliary secretion is generally believed to be an integral step in the pathway of cholesterol excretion from the body. Here we have…”
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Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis by Duijvis, Nicolette W, Moerland, Perry D, Kunne, Cindy, Slaman, Monique M W, van Dooren, Faas H, Vogels, Esther W, de Jonge, Wouter J, Meijer, Sybren L, Fluiter, Kees, Te Velde, Anje A

“…MicroRNAs (miRNAs) are epigenetically involved in regulating gene expression. They may be of importance in the pathogenesis of inflammatory bowel disease…”
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Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease by Gaemers, Ingrid C., Stallen, Jan M., Kunne, Cindy, Wallner, Christian, van Werven, Jochem, Nederveen, Aart, Lamers, Wouter H.

“…The major risk factors for non-alcoholic fatty liver disease (NAFLD) are obesity, insulin resistance and dyslipidemia. The cause for progression from the…”
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Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein by de Waart, Dirk R, Häusler, Stephanie, Vlaming, Maria L H, Kunne, Cindy, Hänggi, Emanuel, Gruss, Hans-Jurgen, Oude Elferink, Ronald P J, Stieger, Bruno

“…Cholyl-L-lysyl-fluorescein (CLF) is a fluorescent bile salt derivative that is being developed as an agent for determining in vivo liver function. However, the…”
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Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content by Paulusma, Coen C., de Waart, D.Rudi, Kunne, Cindy, Mok, Kam S., Elferink, Ronald P.J.Oude

“…Mutations in ATP8B1 cause severe inherited liver disease. The disease is characterized by impaired biliary bile salt excretion (cholestasis), but the mechanism…”
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Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport by Paulusma, Coen C., Groen, Annemiek, Kunne, Cindy, Ho‐Mok, Kam S., Spijkerboer, Astrid L., Rudi de Waart, D., Hoek, Frans J., Vreeling, Heleen, Hoeben, Kees A., van Marle, Jan, Pawlikowska, Ludmila, Bull, Laura N., Hofmann, Alan F., Knisely, A. S., Oude Elferink, Ronald P. J.

“…Progressive familial intrahepatic cholestasis type 1 (PFIC1, Byler disease, OMIM 211600) is a severe inherited liver disease caused by mutations in ATP8B1…”
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Oral availability of cefadroxil depends on ABCC3 and ABCC4 by de Waart, Dirk R, van de Wetering, Koen, Kunne, Cindy, Duijst, Suzanne, Paulusma, Coen C, Oude Elferink, Ronald P J

“…Some cephalosporins, such as cefadroxil, are orally available. H(+)-coupled peptide transporter 1 mediates the transport of cephalosporins across the apical…”
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Glutamine Synthetase in Muscle Is Required for Glutamine Production during Fasting and Extrahepatic Ammonia Detoxification by He, Youji, Hakvoort, Theodorus B.M., Köhler, S. Eleonore, Vermeulen, Jacqueline L.M., de Waart, D. Rudi, de Theije, Chiel, ten Have, Gabrie A.M., van Eijk, Hans M.H., Kunne, Cindy, Labruyere, Wilhelmina T., Houten, Sander M., Sokolovic, Milka, Ruijter, Jan M., Deutz, Nicolaas E.P., Lamers, Wouter H.

“…The main endogenous source of glutamine is de novo synthesis in striated muscle via the enzyme glutamine synthetase (GS). The mice in which GS is selectively…”
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Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis by Kunne, Cindy, de Graaff, Marijke, Duijst, Suzanne, de Waart, Dirk R, Oude Elferink, Ronald P J, Paulusma, Coen C

“…Progressive familial intrahepatic cholestasis (PFIC) types 1 and 3 are severe cholestatic liver diseases caused by deficiency of ATB8B1 and ABCB4,…”
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Complex Pharmacokinetic Behavior of Ezetimibe Depends on Abcc2, Abcc3, and Abcg2 by DE WAART, Dirk R, VLAMING, Maria L. H, KUNNE, Cindy, SCHINKEL, Alfred H, OUDE ELFERINK, Ronald P. J

“…Ezetimibe lowers plasma cholesterol levels by inhibiting the uptake of cholesterol in the intestine. Because of the extensive enterohepatic circulation of…”
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The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol by van Cruchten, Saskia T.J., de Haan, Laura H.J., Mulder, Patrick P.J., Kunne, Cindy, Boekschoten, Mark V., Katan, Martijn B., Aarts, Jac M.M.J.G., Witkamp, Renger F.

“…Cafestol and kahweol are diterpene compounds present in unfiltered coffees. Cafestol is known as the most potent cholesterol-raising agent that may be present…”
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A PYRUVATE-BUFFERED DIALYSIS FLUID INDUCES LESS PERITONEAL ANGIOGENESIS AND FIBROSIS THAN A CONVENTIONAL SOLUTION by van Westrhenen, Roos, Zweers, Machteld M, Kunne, Cindy, de Waart, Dirk R, van der Wal, Allard C, Krediet, Raymond T

“…Division of Nephrology, 1 Department of Medicine; Department of Experimental Hepatology 2 and Department of Cardiovascular Pathology, 3 Academic Medical…”
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Multidrug resistance associated protein 2 mediates transport of prostaglandin E2 by De Waart, Dirk R., Paulusma, Coen C., Kunne, Cindy, Oude Elferink, Ronald P. J.

“…: Background/Aim: Inactivation of prostaglandin E2 (PGE2) in the liver is a rapid process and occurs mainly through β‐oxidation in the peroxisome of the…”
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Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8 by KOSTERS, Astrid, FRIJTERS, Raoul J. J. M, KUNNE, Cindy, VINK, Edwin, SCHNEIDERS, Marit S, SCHAAP, Frank G, NIBBERING, Catherina P, FATEL, Shailendra B, GROEN, Albert K

“…The plant sterol diosgenin has been shown to stimulate biliary cholesterol secretion in mice without affecting the expression of the adenosine…”
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The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice1 by Kosters, Astrid, Kunne, Cindy, Looije, Norbert, Patel, Shailendra B., Oude Elferink, Ronald P.J., Groen, Albert K.

“…The main player in biliary cholesterol secretion is the heterodimeric transporter complex, ABCG5/ABCG8, the function of which is necessary for the majority of…”
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Actual Usage and Quality of Experimental Colitis Models in Preclinical Efficacy Testing: A Scoping Review by Zeeff, Sophia B, Kunne, Cindy, Bouma, Gerd, de Vries, Rob B, Te Velde, Anje A

“…There is no standardized validated experimental model used to predict human drug response, and the choice of model is not based on systematic evidence…”
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FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model by Kunne, Cindy, Acco, Alexandra, Duijst, Suzanne, de Waart, Dirk R., Paulusma, Coen C., Gaemers, Ingrid, Oude Elferink, Ronald P.J.

“…It has been established that bile salts play a role in the regulation of hepatic lipid metabolism. Accordingly, overt signs of steatosis have been observed in…”
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Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides by Zelcer, Noam, Wetering, Koen van de, Waart, Rudi de, Scheffer, George L., Marschall, Hanns-Ulrich, Wielinga, Peter R., Kuil, Annemieke, Kunne, Cindy, Smith, Alexander, Valk, Martin van der, Wijnholds, Jan, Elferink, Ronald Oude, Borst, Piet

“…Multidrug Resistance Protein 3 (MRP3) transports bile salts and glucuronide conjugates in vitro and is postulated to protect the liver in cholestasis. Whether…”
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Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity by Kunne, Cindy, Acco, Alexandra, Hohenester, Simon, Duijst, Suzanne, de Waart, Dirk R., Zamanbin, Alaleh, Oude Elferink, Ronald P.J.

“…The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient…”
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