Search Results - "KUNATH, Klaus"

Polyethylenimine-graft-Poly(ethylene glycol) Copolymers:  Influence of Copolymer Block Structure on DNA Complexation and Biological Activities as Gene Delivery System by Petersen, Holger, Fechner, Petra M, Martin, Alison L, Kunath, Klaus, Stolnik, Snjezana, Roberts, Clive J, Fischer, Dagmar, Davies, Martyn C, Kissel, Thomas

“…For two series of polyethylenimine-graft-poly(ethylene glycol) (PEI-g-PEG) block copolymers, the influence of copolymer structure on DNA complexation was…”
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Integrin targeting using RGD-PEI conjugates for in vitro gene transfer by Kunath, Klaus, Merdan, Thomas, Hegener, Oliver, Häberlein, Hanns, Kissel, Thomas

“…Background Targeting to integrin receptor ανβ3 by RGD peptides seems to be a promising approach for gene delivery to proliferating endothelial cells of tumor…”
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Cogrinding enhances the oral bioavailability of EMD 57033, a poorly water soluble drug, in dogs by Vogt, Markus, Vertzoni, Maria, Kunath, Klaus, Reppas, Christos, Dressman, Jennifer B.

“…The oral bioavailability of EMD 57033, a calcium sensitizing agent with poor solubility, was compared in dogs using four solid dosage form formulation…”
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Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: Comparison with commercial preparations by Vogt, Markus, Kunath, Klaus, Dressman, Jennifer B.

“…Several techniques were compared for improving the dissolution of fenofibrate, a poorly soluble drug. Particle size reduction was realized by jet milling…”
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Dissolution improvement of four poorly water soluble drugs by cogrinding with commonly used excipients by Vogt, Markus, Kunath, Klaus, Dressman, Jennifer B.

“…The rate of the dissolution of four poorly soluble drugs (EMD 57033, albendazole, danazol and felodipine) was improved by cogrinding them with various…”
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Selection of excipient, solvent and packaging to optimize the performance of spray-dried formulations: case example fenofibrate by Hugo, Marc, Kunath, Klaus, Dressman, Jennifer

“…Context: Along with other options, solid dispersions prepared by spray drying offer the possibility of formulating poorly soluble drugs in a rapidly dissolving…”
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Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine by Kunath, Klaus, von Harpe, Anke, Fischer, Dagmar, Petersen, Holger, Bickel, Ulrich, Voigt, Karlheinz, Kissel, Thomas

“…Low-molecular-weight polyethylenimine (LMW-PEI) was synthesized by the acid-catalyzed, ring-opening polymerization of aziridine and compared with commercially…”
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PEGylation of Poly(ethylene imine) Affects Stability of Complexes with Plasmid DNA under in Vivo Conditions in a Dose-Dependent Manner after Intravenous Injection into Mice by Merdan, Thomas, Kunath, Klaus, Petersen, Holger, Bakowsky, Udo, Voigt, Karl Heinz, Kopecek, Jindrich, Kissel, Thomas

“…The influence of PEGylation on polyplex stability from poly(ethylene imine), PEI, and plasmid DNA was investigated both in vitro and after intravenous…”
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Galactose-PEI–DNA complexes for targeted gene delivery: degree of substitution affects complex size and transfection efficiency by Kunath, Klaus, von Harpe, Anke, Fischer, Dagmar, Kissel, Thomas

“…Complexes of galactosylated polyethylenimines (gal-PEI) with DNA have been proposed for gene delivery to hepatocytes. We synthesized gal-PEI with a broad range…”
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Poly(ethylenimine-co-l-lactamide-co-succinamide):  A Biodegradable Polyethylenimine Derivative with an Advantageous pH-Dependent Hydrolytic Degradation for Gene Delivery by Petersen, Holger, Merdan, Thomas, Kunath, Klaus, Fischer, Dagmar, Kissel, Thomas

“…A biodegradable gene transfer vector has been synthesized by linking several low molecular weight (MW) polyethylenimine (PEI, 1200 Da) blocks using an…”
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Poly(diallyldimethylammonium chlorides) and their N-methyl- N-vinylacetamide copolymer-based DNA-polyplexes: role of molecular weight and charge density in complex formation, stability, and in vitro activity by Fischer, Dagmar, Dautzenberg, Herbert, Kunath, Klaus, Kissel, Thomas

“…Poly(diallyldimethylammonium chlorides) (pDADMAC) of different molecular weights (5–244 kDa) and DADMAC/ N-methyl- N-vinylacetamide (NMVA) copolymers…”
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Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines by Petersen, Holger, Kunath, Klaus, Martin, Alison L, Stolnik, Snjezana, Roberts, Clive J, Davies, Martyn C, Kissel, Thomas

“…Star-shaped poly(ethylene glycol)-block-polyethylenimine [star-(PEG-b-PEI)] significantly enhance plasmid DNA condensation of low molecular weight (MW) PEIs…”
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The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-κB decoy in mice by KUNATH, Klaus, VON HARPE, Anke, PETERSEN, Holger, FISCHER, Dagmar, VOIGT, Karlheinz, KISSEL, Thomas, BICKEL, Ulrich

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Pegylated Polyethylenimine−Fab‘ Antibody Fragment Conjugates for Targeted Gene Delivery to Human Ovarian Carcinoma Cells by Merdan, Thomas, Callahan, Jon, Petersen, Holger, Kunath, Klaus, Bakowsky, Udo, Kopečková, Pavla, Kissel, Thomas, Kopeček, Jindřich

“…Specific targeting of ovarian carcinoma cells using pegylated polyethylenimine (PEG−PEI) conjugated to the antigen binding fragment (Fab‘) of the OV-TL16…”
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Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments by MERDAN, Thomas, KUNATH, Klaus, FISCHER, Dagmar, KOPECEK, Jindrich, KISSEL, Thomas

“…Critical steps in the subcellular processing of poly(ethylene imine)/nucleic acid complexes, especially endosomal/lysosomal escape, were visualized by using…”
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Copolymers of Ethylene Imine and N-(2-Hydroxyethyl)-ethylene Imine as Tools To Study Effects of Polymer Structure on Physicochemical and Biological Properties of DNA Complexes by Fischer, Dagmar, von Harpe, Anke, Kunath, Klaus, Petersen, Holger, Li, Youxin, Kissel, Thomas

“…A series of five poly[(ethylene imine)-co-N-(2-hydroxyethyl-ethylene imine)] copolymers with similar molecular weights and different degrees of branching was…”
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The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-[kappa]B decoy in mice by Kunath, Klaus, Anke von Harpe, Petersen, Holger, Fisher, Dagmar

“…To study the relationship between structure of poly(ethylene imine-co-ethylene glycol), PEI-PEG, copolymers and physicochemical properties as well as in vivo…”
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HPMA copolymer–anticancer drug–OV-TL16 antibody conjugates. 3. The effect of free and polymer-bound Adriamycin on the expression of some genes in the OVCAR-3 human ovarian carcinoma cell line by Kunath, Klaus, Kopečková, Pavla, Minko, Tamara, Kopeček, Jindřich

“…The effect of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer–Adriamycin–OV-TLl6 antibody conjugate [P(GFLG)–ADR–Ab] on OVCAR-3 human ovarian carcinoma…”
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The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-kappaB decoy in mice by Kunath, Klaus, von Harpe, Anke, Petersen, Holger, Fischer, Dagmar, Voigt, Karlheinz, Kissel, Thomas, Bickel, Ulrich

“…To study the relationship between structure of poly(ethylene imine-co-ethylene glycol), PEI-PEG, copolymers and physicochemical properties as well as in vivo…”
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Star-Shaped Poly(ethylene glycol)-b lock-polyethylenimine Copolymers Enhance DNA Condensation of Low Molecular Weight Polyethylenimines by Petersen, Holger, Kunath, Klaus, Martin, Alison L, Stolnik, Snjezana, Roberts, Clive J, Davies, Martyn C, Kissel, Thomas

“…Star-shaped poly(ethylene glycol)-block-polyethylenimine [star-(PEG-b-PEI)] significantly enhance plasmid DNA condensation of low molecular weight (MW) PEIs…”
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