Search Results - "KUMMERFELD, Sarah K"

A census of human transcription factors: function, expression and evolution by Vaquerizas, Juan M, Luscombe, Nicholas M, Kummerfeld, Sarah K, Teichmann, Sarah A

“…Key Points Transcription factors (TFs) are key cellular components that control gene expression. Their activity determines how cells function and respond to…”
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Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes by Lewis, Myles J., Barnes, Michael R., Blighe, Kevin, Goldmann, Katriona, Rana, Sharmila, Hackney, Jason A., Ramamoorthi, Nandhini, John, Christopher R., Watson, David S., Kummerfeld, Sarah K., Hands, Rebecca, Riahi, Sudeh, Rocher-Ros, Vidalba, Rivellese, Felice, Humby, Frances, Kelly, Stephen, Bombardieri, Michele, Ng, Nora, DiCicco, Maria, van der Heijde, Désirée, Landewé, Robert, van der Helm-van Mil, Annette, Cauli, Alberto, McInnes, Iain B., Buckley, Christopher D., Choy, Ernest, Taylor, Peter C., Townsend, Michael J., Pitzalis, Costantino

“…There is a current imperative to unravel the hierarchy of molecular pathways that drive the transition of early to established disease in rheumatoid arthritis…”
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ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages by Lee, Bettina L., Mirrashidi, Kathleen M., Stowe, Irma B., Kummerfeld, Sarah K., Watanabe, Colin, Haley, Benjamin, Cuellar, Trinna L., Reichelt, Michael, Kayagaki, Nobuhiko

“…The NLRC4 inflammasome recognizes bacterial flagellin and components of the type III secretion apparatus. NLRC4 stimulation leads to caspase-1 activation…”
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The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification by Abed, Mona, Verschueren, Erik, Budayeva, Hanna, Liu, Peter, Kirkpatrick, Donald S, Reja, Rohit, Kummerfeld, Sarah K, Webster, Joshua D, Gierke, Sarah, Reichelt, Mike, Anderson, Keith R, Newman, Robert J, Roose-Girma, Merone, Modrusan, Zora, Pektas, Hazal, Maltepe, Emin, Newton, Kim, Dixit, Vishva M

“…Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental development. It is thought to derive from a Ty3-gyspy LTR (long…”
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DBD--taxonomically broad transcription factor predictions: new content and functionality by Wilson, Derek, Charoensawan, Varodom, Kummerfeld, Sarah K, Teichmann, Sarah A

“…DNA-binding domain (DBD) is a database of predicted sequence-specific DNA-binding transcription factors (TFs) for all publicly available proteomes. The…”
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Transcription factor Etv5 is essential for the maintenance of alveolar type II cells by Zhang, Zhen, Newton, Kim, Kummerfeld, Sarah K., Webster, Joshua, Kirkpatrick, Donald S., Phu, Lilian, Eastham-Anderson, Jeffrey, Liu, Jinfeng, Lee, Wyne P., Wu, Jiansheng, Li, Hong, Junttila, Melissa R., Dixit, Vishva M.

“…Alveolar type II (AT2) cell dysfunction contributes to a number of significant human pathologies including respiratory distress syndrome, lung adenocarcinoma,…”
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Non-canonical reader modules of BAZ1A promote recovery from DNA damage by Oppikofer, Mariano, Sagolla, Meredith, Haley, Benjamin, Zhang, Hui-Min, Kummerfeld, Sarah K., Sudhamsu, Jawahar, Flynn, E. Megan, Bai, Tianyi, Zhang, Jennifer, Ciferri, Claudio, Cochran, Andrea G.

“…Members of the ISWI family of chromatin remodelers mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA…”
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AGEMAP: a gene expression database for aging in mice by Zahn, Jacob M, Poosala, Suresh, Owen, Art B, Ingram, Donald K, Lustig, Ana, Carter, Arnell, Weeraratna, Ashani T, Taub, Dennis D, Gorospe, Myriam, Mazan-Mamczarz, Krystyna, Lakatta, Edward G, Boheler, Kenneth R, Xu, Xiangru, Mattson, Mark P, Falco, Geppino, Ko, Minoru S H, Schlessinger, David, Firman, Jeffrey, Kummerfeld, Sarah K, Wood, 3rd, William H, Zonderman, Alan B, Kim, Stuart K, Becker, Kevin G

“…We present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database, which is a resource that catalogs changes in gene expression…”
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β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1 by Suriben, Rowena, Kaihara, Kelly A., Paolino, Magdalena, Reichelt, Mike, Kummerfeld, Sarah K., Modrusan, Zora, Dugger, Debra L., Newton, Kim, Sagolla, Meredith, Webster, Joshua D., Liu, Jinfeng, Hebrok, Matthias, Dixit, Vishva M.

“…A variety of signals finely tune insulin secretion by pancreatic β cells to prevent both hyper-and hypoglycemic states. Here, we show that post-translational…”
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Protein domain organisation: adding order by Kummerfeld, Sarah K, Teichmann, Sarah A

“…Domains are the building blocks of proteins. During evolution, they have been duplicated, fused and recombined, to produce proteins with novel structures and…”
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Hyper-IgE Syndrome due to an Elusive Novel Intronic Homozygous Variant in DOCK8 by Tangye, Stuart G., Gray, Paul E., Pillay, Bethany A., Yap, Jin Yan, Figgett, William A., Reeves, John, Kummerfeld, Sarah K., Stoddard, Jennifer, Uzel, Gulbu, Jing, Huie, Su, Helen C., Campbell, Dianne E., Sullivan, Anna, Burnett, Leslie, Peake, Jane, Ma, Cindy S.

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Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics by Dennis, Jr, Glynn, Holweg, Cécile T J, Kummerfeld, Sarah K, Choy, David F, Setiadi, A Francesca, Hackney, Jason A, Haverty, Peter M, Gilbert, Houston, Lin, Wei Yu, Diehl, Lauri, Fischer, S, Song, An, Musselman, David, Klearman, Micki, Gabay, Cem, Kavanaugh, Arthur, Endres, Judith, Fox, David A, Martin, Flavius, Townsend, Michael J

“…Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune disease. Currently, the relationship between pathogenic molecular drivers of…”
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Discrimination of Non-Protein-Coding Transcripts from Protein-Coding mRNA by Frith, Martin C., Bailey, Timothy L., Kasukawa, Takeya, Mignone, Flavio, Kummerfeld, Sarah K., Madera, Martin, Sunkara, Sirisha, Furuno, Masaaki, Bult, Carol J., Quackenbush, John, Kai, Chikatoshi, Kawai, Jun, Carninci, Piero, Hayashizaki, Yoshihide, Pesole, Graziano, Mattick, John S.

“…Several recent studies indicate that mammals and other organisms produce large numbers of RNA transcripts that do not correspond to known genes. It has been…”
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DBD: a transcription factor prediction database by Kummerfeld, Sarah K, Teichmann, Sarah A

“…Regulation of gene expression influences almost all biological processes in an organism; sequence-specific DNA-binding transcription factors are critical to…”
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gCMAP: user-friendly connectivity mapping with R by Sandmann, Thomas, Kummerfeld, Sarah K, Gentleman, Robert, Bourgon, Richard

“…Connections between disease phenotypes and drug effects can be made by identifying commonalities in the associated patterns of differential gene expression…”
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The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation by Galeano Niño, Jorge Luis, Tay, Szun S, Tearle, Jacqueline L E, Xie, Jianling, Govendir, Matt A, Kempe, Daryan, Mazalo, Jessica, Drew, Alexander P, Colakoglu, Feyza, Kummerfeld, Sarah K, Proud, Christopher G, Biro, Maté

“…It has become increasingly evident that T cell functions are subject to translational control in addition to transcriptional regulation. Here, by using live…”
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Hyper-IgE Syndrome due to an Elusive Novel Intronic Homozygous Variant in DOCK8 by Tangye, Stuart G., Gray, Paul E., Pillay, Bethany A., Yap, Jin Yan, Figgett, William A., Reeves, John, Kummerfeld, Sarah K., Stoddard, Jennifer, Uzel, Gulbu, Jing, Huie, Su, Helen C., Campbell, Dianne E., Sullivan, Anna, Burnett, Leslie, Peake, Jane, Ma, Cindy S.

“…Rare, biallelic loss-of-function mutations in DOCK8 result in a combined immune deficiency characterized by severe and recurrent cutaneous infections, eczema,…”
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Relative rates of gene fusion and fission in multi-domain proteins by Kummerfeld, Sarah K., Teichmann, Sarah A.

“…During evolution genes can produce more complex proteins by gene fusion or less complex proteins by gene fission. Considering proteins from 131 completely…”
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The SUPERFAMILY database in 2004: additions and improvements by Madera, Martin, Vogel, Christine, Kummerfeld, Sarah K., Chothia, Cyrus, Gough, Julian

“…The SUPERFAMILY database provides structural assignments to protein sequences and a framework for analysis of the results. At the core of the database is a…”
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Sticking together? Falling apart? Exploring the dynamics of the interactome by Wilkins, Marc R., Kummerfeld, Sarah K.

“…Advances in techniques for the study of protein–protein interactions have dramatically improved our understanding of the interactome. However, we know little…”
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