Search Results - "KUMMER, Wolfgang"
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Histology by Mass Spectrometry: Label-Free Tissue Characterization Obtained from High-Accuracy Bioanalytical Imaging
Published in Angewandte Chemie (International ed.) (17-05-2010)“…Next‐generation imaging mass spectrometry of biological tissue on the cellular level shows excellent agreement with histochemical evaluation whilst providing a…”
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Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes
Published in Proceedings of the National Academy of Sciences - PNAS (03-06-2014)“…Chemosensory cells in the mucosal surface of the respiratory tract (“brush cells”) use the canonical taste transduction cascade to detect potentially hazardous…”
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Cholinergic chemosensory cells in the trachea regulate breathing
Published in Proceedings of the National Academy of Sciences - PNAS (07-06-2011)“…In the epithelium of the lower airways, a cell type of unknown function has been termed "brush cell" because of a distinctive ultrastructural feature, an…”
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Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors
Published in Scientific reports (08-08-2024)“…Disorders of gallbladder motility can lead to serious pathology. Bitter tastants acting upon bitter taste receptors (TAS2R family) have been proposed as a…”
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TASK-1 potassium channel is not critically involved in mediating hypoxic pulmonary vasoconstriction of murine intra-pulmonary arteries
Published in PloS one (16-03-2017)“…The two-pore domain potassium channel KCNK3 (TASK-1) is expressed in rat and human pulmonary artery smooth muscle cells. There, it is associated with…”
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Mental stress in atopic dermatitis--neuronal plasticity and the cholinergic system are affected in atopic dermatitis and in response to acute experimental mental stress in a randomized controlled pilot study
Published in PloS one (02-12-2014)“…In mouse models for atopic dermatitis (AD) hypothalamus pituitary adrenal axis (HPA) dysfunction and neuropeptide-dependent neurogenic inflammation explain…”
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Avertin®, but Not Volatile Anesthetics Addressing the Two-Pore Domain K+ Channel, TASK-1, Slows Down Cilia-Driven Particle Transport in the Mouse Trachea
Published in PloS one (08-12-2016)“…Volatile anesthetics inhibit mucociliary clearance in the airways. The two-pore domain K+ channel, TASK-1, represents one of their molecular targets in that…”
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TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells
Published in BMC neuroscience (04-07-2007)“…A growing number of TRP channels have been identified as key players in the sensation of smell, temperature, mechanical forces and taste. TRPM5 is known to be…”
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Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages
Published in PloS one (13-10-2016)“…Members of the calcitonin peptide family-calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and adrenomedullin2/intermedin (IMD)-exert modulatory…”
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Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract
Published in Frontiers in physiology (24-03-2015)“…The mouse gastro-intestinal and biliary tract mucosal epithelia harbor choline acetyltransferase (ChAT)-positive brush cells with taste cell-like traits. With…”
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Ciliary Transport, Gamete Interaction, and Effects of the Early Embryo in the Oviduct: Ex Vivo Analyses Using a New Digital Videomicroscopic System in the Cow
Published in Biology of reproduction (01-08-2009)“…Using a digital videomicroscopic analysis system in the bovine, we showed that the mechanisms of transport caused by ciliary beating are distinctly different…”
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Recent progress in revealing the biological and medical significance of the non-neuronal cholinergic system
Published in International immunopharmacology (01-11-2015)“…This special issue of International Immunopharmacology is the proceedings of the Fourth International Symposium on Non-neuronal Acetylcholine that was held on…”
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C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation
Published in Frontiers in immunology (30-07-2018)“…Blood levels of the acute phase reactant C-reactive protein (CRP) are frequently measured as a clinical marker for inflammation, but the biological functions…”
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Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-04-2009)“…Acetylcholine (ACh) is a major regulator of visceral function exerting pharmacologically relevant effects upon smooth muscle tone and epithelial function via…”
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Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature
Published in Circulation research (03-08-2007)“…Nonphagocytic NADPH oxidases have recently been suggested to play a major role in the regulation of physiological and pathophysiological processes, in…”
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Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice
Published in Scientific reports (09-04-2018)“…Several species of the Gram-negative genus Bordetella are the cause of respiratory infections in mammals and birds, including whooping cough (pertussis) in…”
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Expression and distribution of cholinergic receptors in the human urothelium
Published in Life sciences (1973) (30-05-2007)“…The bladder urothelium not only provides a diffusion barrier but it also serves a sensor function and releases signalling molecules that are considered to act…”
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Substance P Receptor in the Rat Heart and Regulation of Its Expression in Long-Term Diabetes
Published in Frontiers in physiology (13-07-2018)“…Substance P (SP) is a neuropeptide engaged in the signal transmission of neural C fibers afferents in the myocardium. The actions of SP in the heart are…”
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Distribution of Endothelin Receptor Subtypes ETA and ETB in the Rat Kidney
Published in The journal of histochemistry and cytochemistry (01-11-2006)“…The endothelin (ET) receptor system is markedly involved in the regulation of renal function under both physiological and pathophysiological conditions. The…”
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Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice
Published in Frontiers in cellular neuroscience (12-09-2017)“…The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are likely to be the evolutionary precursors to the entire cys-loop superfamily of…”
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