Search Results - "KUMMER, J. A."

Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels by Rutges, JPHJ, Kummer, JA, Oner, FC, Verbout, AJ, Castelein, RJM, Roestenburg, HJA, Dhert, WJA, Creemers, LB

“…Intervertebral disc (IVD) degeneration is associated with the increased expression of several matrix metalloproteinases (MMPs), in particular MMP-2. However,…”
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Human papillomavirus is a necessary cause of invasive cervical cancer worldwide by Walboomers, Jan M. M., Jacobs, Marcel V., Manos, M. Michele, Bosch, F. Xavier, Kummer, J. Alain, Shah, Keerti V., Snijders, Peter J. F., Peto, Julian, Meijer, Chris J. L. M., Muñoz, Nubia

“…A recent report that 93 per cent of invasive cervical cancers worldwide contain human papillomavirus (HPV) may be an underestimate, due to sample inadequacy or…”
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Hair follicles as a niche of Staphylococcus aureus in the nose; is a more effective decolonisation strategy needed? by ten Broeke-Smits, N.J.P, Kummer, J.A, Bleys, R.L.A.W, Fluit, A.C, Boel, C.H.E

“…Summary Staphylococcus aureus is the major cause of surgical site infections, and meticillin-resistant S. aureus (MRSA) is increasingly accounting for…”
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Persistence of genetically altered fields in head and neck cancer patients: Biological and clinical implications by TABOR, Maarten P, BRAKENHOFF, Ruud H, VAN HOUTEN, Viola M. M, ALAIN KUMMER, J, SNEL, Mireille H. J, SNIJDERS, Peter J. F, SNOW, Gordon B, RENE LEEMANS, C, BRAAKHUIS, Boudewijn J. M

“…In 1953, Slaughter et al. [D. P. Slaughter et al., Cancer (Phila.), 6: 963-968, 1953] proposed the concept of field cancerization in patients with squamous…”
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DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients by Jonkers, Y M H, Claessen, S M H, Perren, A, Schmitt, A M, Hofland, L J, de Herder, W, de Krijger, R R, Verhofstad, A A J, Hermus, A R, Kummer, J A, Skogseid, B, Volante, M, Voogd, A C, Ramaekers, F C S, Speel, E J M

“…The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict in the absence of metastases or invasion to adjacent organs. Several…”
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Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells by Medema, J P, Schuurhuis, D H, Rea, D, van Tongeren, J, de Jong, J, Bres, S A, Laban, S, Toes, R E, Toebes, M, Schumacher, T N, Bladergroen, B A, Ossendorp, F, Kummer, J A, Melief, C J, Offringa, R

“…Dendritic cells (DCs) play a central role in the immune system as they drive activation of T lymphocytes by cognate interactions. However, as DCs express high…”
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Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis by Oberhuber, G, Vogelsang, H, Stolte, M, Muthenthaler, S, Kummer, AJ, Radaszkiewicz, T

“…To further define intraepithelial lymphocytes (IELs) in celiac disease (CD) and giardiasis, IELs were probed for the presence of cytolytic granules containing…”
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The Granzyme B Inhibitor, Protease Inhibitor 9, Is Mainly Expressed by Dendritic Cells and at Immune-Privileged Sites by Bladergroen, Bellinda A, Strik, Merel C. M, Bovenschen, Niels, van Berkum, Oskar, Scheffer, George L, Meijer, Chris J. L. M, Hack, C. Erik, Kummer, J. Alain

“…Granzyme B is released from CTLs and NK cells and an important mediator of CTL/NK-induced apoptosis in target cells. The human intracellular serpin proteinase…”
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A validated new histological classification for intervertebral disc degeneration by Rutges, J.P.H.J, Duit, R.A, Kummer, J.A, Bekkers, J.E.J, Oner, F.C, Castelein, R.M, Dhert, W.J.A, Creemers, L.B

“…Summary Histology is an important outcome variable in basic science and pre-clinical studies regarding intervertebral disc degeneration (IVD). Nevertheless, an…”
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Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas by MURIS, J. J. F, MEIJER, Cjlm, OSSENKOPPELE, G. J, OUDEJANS, J. J, CILLESSEN, Sagm, VOS, W, KUMMER, J. A, BLADERGROEN, B. A, BOGMAN, Mjjt, MACKENZIE, M. A, JIWA, N. M, SIEGENBEEK VAN HEUKELOM, L. H

“…Clinical outcome in diffuse large B-cell lymphoma (DLBCL) remains unpredictable, despite the identification of clinical prognostic parameters. Here, we…”
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Anaplastic Large-Cell Lymphomas of T-Cell and Null-Cell Phenotype Express Cytotoxic Molecules by Foss, Hans-Dieter, Anagnostopoulos, loannis, Araujo, Iguaracyra, Assaf, Chalid, Demel, Gudrun, Kummer, J.Alain, Hummel, Michael, Stein, Harald

“…To further specify the cellular origin and nature of anaplastic large-cell lymphoma (ALCL) and its relationship to other lymphoid neoplasms, particularly…”
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Activated cytotoxic T cells as prognostic marker in Hodgkin's disease by OUDEJANS, J. J, JIWA, N. M, MEIJER, C. J. L. M, KUMMER, J. A, OSSENKOPPELE, G. J, VAN HEERDE, P, BAARS, J. W, KLUIN, P. M, KLUIN-NELEMANS, J. C, VAN DIEST, P. J, MIDDELDORP, J. M

“…Although the results of treatment of Hodgkin's disease (HD) have improved considerably in the last decades, the disease remains fatal in a minority of…”
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Expression of c-FLIP is primarily detected in diffuse large B-cell lymphoma and Hodgkin's lymphoma and correlates with lack of caspase 8 activation by Van Houdt, I S, Muris, J J, Hesselink, A T, Kramer, D, Cillessen, S A G M, Moesbergen, L M, Vos, W, Hooijberg, E, Meijer, C J L M, Kummer, J A, Oudejans, J J

“…Aims:  Inhibition of apoptosis is important in the pathogenesis of lymphomas. c‐FLIP, a regulator of caspase 8‐mediated apoptosis, plays an important role in…”
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Analysis of Major Histocompatibility Complex Class I Expression on Reed-Sternberg Cells in Relation to the Cytotoxic T-Cell Response in Epstein-Barr Virus-Positive and -Negative Hodgkin's Disease by Oudejans, J.J., Jiwa, N.M., Kummer, J.A., Horstman, A., Vos, W., Baak, J.P.A., Kluin, Ph.M., Valk, P. van der, Walboomers, J.M.M., Meijer, C.J.L.M.

“…To get insight into the failure of the immune system to eradicate Epstein-Barr virus (EBV) harboring Hodgkin and Reed-Sternberg cells (H-RS cells), expressing…”
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Extracellular Granzymes A and B in Humans: Detection of Native Species During CTL Responses In Vitro and In Vivo by Spaeny-Dekking, Elisabeth H. A, Hanna, William L, Wolbink, Angela M, Wever, Peter C, Kummer, Alain J, Swaak, Anton J. G, Middeldorp, Jaap M, Huisman, Han G, Froelich, Christopher J, Hack, C. Erik

“…Activated CTLs and NK cells induce apoptosis via multiple mechanisms, including that termed granule exocytosis. The latter pathway consists of vectorial…”
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Hypertrophic differentiation and calcification during intervertebral disc degeneration by Rutges, J.P.H.J, Duit, R.A, Kummer, J.A, Oner, F.C, van Rijen, M.H, Verbout, A.J, Castelein, R.M, Dhert, W.J.A, Creemers, L.B

“…Summary Background In degenerative intervertebral discs (IVDs) collagen type X expression and calcifications have been demonstrated, resembling advanced…”
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Molecular Assays for the Diagnosis of Minimal Residual Head-and-Neck Cancer: Methods, Reliability, Pitfalls, and Solutions by VAN HOUTEN, Vida M. M, TABOR, Maarten P, VAN DEN BREKEL, Michiel W. M, DENKERS, Fedor, WISHAUPT, Richard G. A, KUMMER, J. Alain, SNOW, Gordon B, BRAKENHOFF, Ruud H

“…The prognosis of cancer patients is determined by the radicalness of treatment: residual tumor cells will grow out and develop in manifest local recurrences,…”
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Most Primary Cutaneous CD30-Positive Lymphoproliferative Disorders Have a CD4-Positive Cytotoxic T-Cell Phenotype by Kummer, Jean Alain, Vermeer, Maarten H., Dukers, Danny, Meijer, Chris J.L.M., Willemze, Rein

“…Primary cutaneous CD30-positive (anaplastic) large T-cell lymphomas and lymphomatoid papulosis are closely related types of cutaneous T-cell lymphoma with a…”
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T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma by Mulder, W M, Bloemena, E, Stukart, M J, Kummer, J A, Wagstaff, J, Scheper, R J

“…BACKGROUND: Whereas the presence of a lymphoid infiltrate has been associated with a favourable prognosis in colorectal carcinoma, the proliferative and…”
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Nonresolving pneumonia in mycoplasma pneumoniae infection resembling a lung tumor by Susanto, C R, Vonk-Noordegraaf, A, Kummer, J A, Boonstra, A

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