Search Results - "KUME, Shinichi"

Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats by MAEKAWA, Tatsuya, SUGIMOTO, Miki, KUME, Shinichi, OHTA, Takeshi

“…Diabetes mellitus (DM) and obesity are associated with neurodegenerative diseases such as Alzheimer’s disease and psychiatric disorders such as major…”
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Lipofection of siRNA into bovine 8-16-cell stage embryos using zona removal and the well-of-the-well culture system by IKEDA, Shuntaro, SUGIMOTO, Miki, KUME, Shinichi

“…Bovine preimplantation embryos exhibit dramatic biological changes between before and after the 8-16-cell stage. Here we report a simple lipofection method to…”
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Embryonic MTHFR contributes to blastocyst development by Ishitani, Hiroki, Ikeda, Shuntaro, Egashira, Kai, Sugimoto, Miki, Kume, Shinichi, Minami, Naojiro, Ohta, Takeshi

“…Purpose Reduction in methylenetetrahydrofolate reductase (MTHFR) activity due to genetic variations in the MTHFR gene has been controversially implicated in…”
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Methionine-dependent histone methylation at developmentally important gene loci in mouse preimplantation embryos by Kudo, Mari, Ikeda, Shuntaro, Sugimoto, Miki, Kume, Shinichi

“…The involvement of specific nutrients in epigenetic gene regulation is a possible mechanism underlying nutrition-directed phenotypic alteration. However, the…”
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Effectiveness of a Driver Assistance System With Deceleration Control and Brake Hold Functions in Stop Sign Intersection Scenarios by Saito, Yuichi, Yoshimi, Ryoma, Kume, Shinichi, Shen, Xun, Yamasaki, Akito, Matsumi, Ryosuke, Ito, Takuma, Kinoshita, Toshiki, Inoue, Shintaro, Shimizu, Tsukasa, Nagai, Masao, Inoue, Hideo, Raksincharoensak, Pongsathorn

“…Elderly drivers often tend to disobey stop signs, and the number of vehicle accidents associated with this is increasing. The problem we address in this work…”
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Role of methionine adenosyltransferase 2A in bovine preimplantation development and its associated genomic regions by Ikeda, Shuntaro, Kawahara-Miki, Ryouka, Iwata, Hisataka, Sugimoto, Miki, Kume, Shinichi

“…Methionine adenosyltransferase (MAT) is involved in folate-mediated one-carbon metabolism, which is essential for preimplantation embryos in terms of both…”
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Importance of Methionine Metabolism in Morula-to-blastocyst Transition in Bovine Preimplantation Embryos by IKEDA, Shuntaro, SUGIMOTO, Miki, KUME, Shinichi

“…The roles of methionine metabolism in bovine preimplantation embryo development were investigated by using ethionine, an antimetabolite of methionine. In vitro…”
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Effects of a driver assistance system with foresighted deceleration control on the driving performance of elderly and younger drivers by Saito, Yuichi, Yoshimi, Ryoma, Kume, Shinichi, Imai, Masahiro, Yamasaki, Akito, Ito, Takuma, Inoue, Shintaro, Shimizu, Tsukasa, Nagai, Masao, Inoue, Hideo, Raksincharoensak, Pongsathorn

“…•Deceleration control was designed to guide a driver to hazard-anticipatory driving.•Effects of this approach were investigated by conducting a public-road…”
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Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-Lepr fa (SDT fatty) rats, a novel type 2 diabetic model by MAEKAWA, Tatsuya, OHTA, Takeshi, KUME, Shinichi

“…In recent years, a relationship between diabetes and neurodegenerative diseases, such as Parkinson’s disease, Alzheimer disease or depression, has been…”
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Pathophysiological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model by Maekawa, Tatsuya, Tadaki, Hironobu, Sasase, Tomohiko, Motohashi, Yu, Miyajima, Katsuhiro, Ohta, Takeshi, Kume, Shinichi

“…To establish an animal model for diabetic peripheral neuropathy (DPN) at an earlier stage, we performed functional and pathophysiological evaluations in…”
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JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity by Okuma, Chihiro, Ohta, Takeshi, Tadaki, Hironobu, Hamada, Hiromi, Oda, Tomohiro, Taniuchi, Hideyuki, Yamanaka, Kenji, Ishii, Yukihito, Ohe, Yasuhiro, Yata, Shinji, Nishiu, Jun, Aratsu, Yusuke, Oshida, Shinichi, Kume, Shinichi, Kakutani, Makoto

“…Monoacylglycerol acyltransferase 2 (MGAT2) plays an important role in intestinal fat absorption. We discovered the novel MGAT2 inhibitor, JTP-103237, and…”
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Identification, Isolation, and In Vitro Culture of Porcine Gonocytes by Goel, Sandeep, Sugimoto, Miki, Minami, Naojiro, Yamada, Masayasu, Kume, Shinichi, Imai, Hiroshi

“…Gonocytes are primitive germ cells that reside in the seminiferous tubules of neonatal testes and give rise to spermatogonia, thereby initiating…”
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Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model by TORINIWA, Yasufumi, SAITO, Tomoyuki, MIYAJIMA, Katsuhiro, ISHII, Yukihito, UNO, Kinuko, MAEKAWA, Tatsuya, MATSUI, Tohru, KUME, Shinichi, YAMADA, Takahisa, OHTA, Takeshi

“…Nonalcoholic steatohepatitis (NASH) is a progressive liver disease, and some patients develop hepatic cirrhosis/carcinoma. Animal models play key roles in the…”
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Roles of One-carbon Metabolism in Preimplantation Period: Effects on Short-term Development and Long-term Programming by IKEDA, Shuntaro, KOYAMA, Hiroyuki, SUGIMOTO, Miki, KUME, Shinichi

“…One-carbon metabolism (OCM) can be seen as integrated metabolic pathways centered on the metabolism of two nutritional substances, folate and methionine…”
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JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis by Okuma, Chihiro, Ohta, Takeshi, Tadaki, Hironobu, Ishigure, Tatsuya, Sakata, Shohei, Taniuchi, Hideyuki, Sano, Ryuhei, Hamada, Hiromi, Kume, Shinichi, Nishiu, Jun, Kakutani, Makoto

“…Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still…”
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Effects of astaxanthin‐enriched yeast on mucosal IgA induction in the jejunum and ileum of weanling mice by Nagayama, Tatsuhiko, Sugimoto, Miki, Ikeda, Shuntaro, Kume, Shinichi

“…The present study was conducted to clarify the effects of astaxanthin‐enriched yeast on the concentration of immunoglobulin A (IgA), the numbers of IgA…”
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Intrajejunal infusion of 2-monoacylglycerol reduced food intake without inducing diarrhea in rats by Okuma, Chihiro, Ohta, Takeshi, Ito, Makoto, Tadaki, Hironobu, Oda, Tomohiro, Kume, Shinichi, Nishiu, Jun, Kakutani, Makoto

“…Some nutrients, such as carbohydrate, fat and protein, are known to stimulate satiety. However, the effect of sn-2-monoacylglycerol (2-MG), one of the…”
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Relationships between immunoglobulin M and immunoglobulin G or A in colostrum of Japanese black multiparous cows by Taniguchi, Saya, Wang, Mengdong, Ikeda, Shuntaro, Yoshioka, Hidetugu, Nagase, Hiroshi, Kitamura, Shoko, Itoyama, Erina, Murakami, Hiroaki, Sugimoto, Miki, Kume, Shinichi

“…This study was conducted to clarify the relationships among immunoglobulin (Ig)M, IgG, IgA, β‐carotene, vitamin A and α‐tocopherol contents in colostrum of 24…”
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Effects of supplemental β‐carotene on colostral immunoglobulin and plasma β‐carotene and immunoglobulin in Japanese Black cows by Ishida, Maho, Nishijima, Yoshitaka, Ikeda, Shuntaro, Yoshitani, Kenichi, Obata, Atsutoshi, Sugie, Yuji, Aoki, Yoshikazu, Yamaji, Taisuke, Fujita, Masahiko, Nakatsuji, Yoshinobu, Kume, Shinichi

“…Data from 26 Japanese Black cows were collected to clarify the effects of supplemental β‐carotene on colostral immunoglobulin (Ig) and plasma β‐carotene and Ig…”
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Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin by KATSUDA, Yoshiaki, SASASE, Tomohiko, TADAKI, Hironobu, MERA, Yasuko, MOTOHASHI, Yu, Kemmochi, Yusuke, TOYODA, Kaoru, KAKIMOTO, Kochi, KUME, Shinichi, OHTA, Takeshi

“…The spontaneously diabetic torii (SDT) fatty rat is a new model of type 2 diabetes showing overt obesity, hyperglycemia and hyperlipidemia. With early onset of…”
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