Search Results - "KUMAMARU, EMI"

Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-γ signaling for glutamate release via a glutamate transporter by Numakawa, Tadahiro, Kumamaru, Emi, Adachi, Naoki, Yagasaki, Yuki, Izumi, Aiko, Kunugi, Hiroshi

“…An increase in glucocorticoid levels and down-regulation of BDNF (brain-derived neurotrophic factor) are supposed to be involved in the pathophysiology of…”
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Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons by Kumamaru, Emi, Egashira, Yoshihiro, Takenaka, Rie, Takamori, Shigeo

“…•Exposure of valproic acid to cultured cortical neurons decreased VGAT expression.•The reduction of VGAT by valproic acid was through its HDAC inhibition…”
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Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling by HASHIMOTO, Ryota, NUMAKAWA, Tadahiro, CHIBA, Sachie, NOGUCHI, Hiroko, SUZUKI, Tatsuyo, IWATA, Nakao, OZAKI, Norio, TAGUCHI, Takahisa, KAMIYA, Atsushi, KOSUGA, Asako, TATSUMI, Masahiko, KAMIJIMA, Kunitoshi, OHNISHI, Takashi, WEINBERGER, Daniel R, SAWA, Akira, KUNUGI, Hiroshi, KUMAMARU, Emi, YAGASAKI, Yuki, ISHIMOTO, Tetsuya, MORI, Takeyuki, NEMOTO, Kiyotaka, ADACHI, Naoki, IZUMI, Aiko

“…Disrupted-in-schizophrenia 1 (DISC1), identified in a pedigree with a familial psychosis with the chromosome translocation (1:11), is a putative susceptibility…”
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Glucocorticoid Prevents Brain-Derived Neurotrophic Factor-Mediated Maturation of Synaptic Function in Developing Hippocampal Neurons through Reduction in the Activity of Mitogen-Activated Protein Kinase by Kumamaru, Emi, Numakawa, Tadahiro, Adachi, Naoki, Yagasaki, Yuki, Izumi, Aiko, Niyaz, Madinyet, Kudo, Motoshige, Kunugi, Hiroshi

“…An increased level of glucocorticoid may be related to the pathophysiology of depressive disorder. The involvement of brain-derived neurotrophic factor (BDNF)…”
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SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression by Tuerxun, Tuerhong, Numakawa, Tadahiro, Adachi, Naoki, Kumamaru, Emi, Kitazawa, Hiromi, Kudo, Motoshige, Kunugi, Hiroshi

“…Many studies suggest that antidepressants act as neuroprotective agents in the central nervous system (CNS), though the underlying mechanism has not been fully…”
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Chronic Antidepressants Potentiate via Sigma-1 Receptors the Brain-derived Neurotrophic Factor-induced Signaling for Glutamate Release by Yagasaki, Yuki, Numakawa, Tadahiro, Kumamaru, Emi, Hayashi, Teruo, Su, Tsung-Ping, Kunugi, Hiroshi

“…Up-regulation of BDNF (brain-derived neurotrophic factor) has been suggested to contribute to the action of antidepressants. However, it is unclear whether…”
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Vitamin E protected cultured cortical neurons from oxidative stress‐induced cell death through the activation of mitogen‐activated protein kinase and phosphatidylinositol 3‐kinase by Numakawa, Yumiko, Numakawa, Tadahiro, Matsumoto, Tomoya, Yagasaki, Yuki, Kumamaru, Emi, Kunugi, Hiroshi, Taguchi, Takahisa, Niki, Etsuo

“…The role of vitamin E in the CNS has not been fully elucidated. In the present study, we found that pre‐treatment with vitamin E analogs including αT…”
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MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling by Niyaz, Madinyet, Numakawa, Tadahiro, Matsuki, Yoshinori, Kumamaru, Emi, Adachi, Naoki, Kitazawa, Hiromi, Kunugi, Hiroshi, Kudo, Motoshige

“…The mechanism by which MCI‐186 (3‐methyl‐1‐phenyl‐2‐prazolin‐5‐one) exerts protective effects during cerebral infarction, other than its function as a radical…”
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BDNF function and intracellular signaling in neurons by Numakawa, Tadahiro, Suzuki, Shingo, Kumamaru, Emi, Adachi, Naoki, Richards, Misty, Kunugi, Hiroshi

“…Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF/TrkB-stimulated…”
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Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB by Kumamaru, Emi, Numakawa, Tadahiro, Adachi, Naoki, Kunugi, Hiroshi

“…► Glucocorticoid reduced the BDNF-increased synapse via inhibiting activation of ERK. ► BDNF-dependent interaction of Shp2 with TrkB was diminished by…”
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Phencyclidine-induced decrease of synaptic connectivity via inhibition of BDNF secretion in cultured cortical neurons by Adachi, Naoki, Numakawa, Tadahiro, Kumamaru, Emi, Itami, Chiaki, Chiba, Shuichi, Iijima, Yoshimi, Richards, Misty, Katoh-Semba, Ritsuko, Kunugi, Hiroshi

“…Repeated administration of phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor blocker, produces schizophrenia-like behaviors in humans…”
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Cyclophosphamide promotes cell survival via activation of intracellular signaling in cultured cortical neurons by Kitazawa, Hiromi, Numakawa, Tadahiro, Adachi, Naoki, Kumamaru, Emi, Tuerxun, Tuerhong, Kudo, Motoshige, Kunugi, Hiroshi

“…Cyclophosphamide (CP) has been used as an antitumour agent or immunosuppressant clinically, though the potential biological role of CP in the central nervous…”
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Arc interacts with microtubules/microtubule-associated protein 2 and attenuates microtubule-associated protein 2 immunoreactivity in the dendrites by Fujimoto, Takahiro, Tanaka, Hidekazu, Kumamaru, Emi, Okamura, Ko, Miki, Naomasa

“…Arc, activity‐regulated cytoskeleton‐associated gene, is an immediate early gene, and its expression is regulated by a variety of stimuli, such as electric…”
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bFGF reversed a suppression in BDNF-stimulated glutamate release caused by glucocorticoid exposure by Numakawa, Tadahiro, Adachi, Naoki, Kumamaru, Emi, Kunugi, Hiroshi

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Possible involvement of BDNF dysfunction in the synaptic loss caused by phencyclidine by Adachi, Naoki, Numakawa, Tadahiro, Kumamaru, Emi, Itami, Chiaki, Chiba, Shuichi, Iijima, Yoshimi, Richards, Misty, Katoh-Semba, Ritsuko, Kunugi, Hiroshi

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Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-[gamma] signaling for glutamate release via a glutamate transporter by Numakawa, Tadahiro, Kumamaru, Emi, Adachi, Naoki, Yagasaki, Yuki, Izumi, Aiko, Kunugi, Hiroshi

“…An increase in glucocorticoid levels and down-regulation of BDNF (brain-derived neurotrophic factor) are supposed to be involved in the pathophysiology of…”
Get full text

Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-γ signaling for glutamate release via a glutamate transporter by Numakawa, Tadahiro, Kumamaru, Emi, Adachi, Naoki, Yagasaki, Yuki, Izumi, Aiko, Kunugi, Hiroshi

“…An increase in glucocorticoid levels and down-regulation of BDNF (brain-derived neurotrophic factor) are supposed to be involved in the pathophysiology of…”
Get full text

Phencyclidine decreases excitatory synaptic sites through suppression of BDNF secretion in cortical neurons by Adachi, Naoki, Numakawa, Tadahiro, Kumamaru, Emi, Itami, Chiaki, Katoh-Semba, Ritsuko, Kunigi, Hiroshi

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Phencyclidine rapidly induced glutamate release and increased BDNF expression in cultured cortical neurons by Adachi, Naoki, Numakawa, Tadahiro, Kumamaru, Emi, Izumi, Aiko, Kunugi, Hiroshi

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Survival effect of cyclophosphamide in cultured cortical neurons by Kitazawa, Hiromi, Numakawa, Tadahiro, Adachi, Naoki, Kumamaru, Emi, Niyaz, Madinyet, Izumi, Aiko, Kunugi, Hiroshi, Kudo, Motoshige

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