Search Results - "KUIPERS, Thomas"

LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation by Fan, Chuannan, Wang, Qian, Kuipers, Thomas B, Cats, Davy, Iyengar, Prasanna Vasudevan, Hagenaars, Sophie C, Mesker, Wilma E, Devilee, Peter, Tollenaar, Rob A E M, Mei, Hailiang, ten Dijke, Peter

“…Epithelial cells acquire mesenchymal phenotypes through epithelial‐mesenchymal transition (EMT) during cancer progression. However, how epithelial cells retain…”
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The lncRNA LETS1 promotes TGF-β-induced EMT and cancer cell migration by transcriptionally activating a TβR1-stabilizing mechanism by Fan, Chuannan, González-Prieto, Román, Kuipers, Thomas B, Vertegaal, Alfred C O, van Veelen, Peter A, Mei, Hailiang, Ten Dijke, Peter

“…Transforming growth factor-β (TGF-β) signaling is a critical driver of epithelial-to-mesenchymal transition (EMT) and cancer progression. In SMAD-dependent…”
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Is the healthcare provision in the Netherlands compliant with universal health coverage based on the right to health? A narrative literature review by Kuipers, Thomas, van de Pas, Remco, Krumeich, Anja

“…Universal health coverage, as one of the targets of the Sustainable Development Goals, is the access to key promotive, preventive, curative and rehabilitative…”
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Improved Sézary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sézary syndrome by Najidh, Safa, Tensen, Cornelis P., van der Sluijs-Gelling, Alita J., Teodosio, Cristina, Cats, Davy, Mei, Hailiang, Kuipers, Thomas B., Out-Luijting, Jacoba J., Zoutman, Willem H., van Hall, Thorbald, Orfao, Alberto, Almeida, Julia, van Dongen, Jacques J.M., Vermeer, Maarten H.

“…Sézary syndrome (SS) is an aggressive leukemic form of cutaneous T-cell lymphoma with neoplastic CD4+ T cells present in skin, lymph nodes, and blood. Despite…”
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Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases by Taeubert, M Jazmin, Kuipers, Thomas B, Zhou, Jiayi, Li, Chihua, Wang, Shuang, Wang, Tian, Tobi, Elmar W, Belsky, Daniel W, Lumey, L H, Heijmans, Bastiaan T

“…Exposure to famine in the prenatal period is associated with an increased risk of metabolic disease, including obesity and type 2 diabetes. We employed nuclear…”
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Transcriptomic profiling of Polycystic Kidney Disease identifies paracrine factors in the early cyst microenvironment by Yasinoglu, Sevtap A, Kuipers, Thomas B, Suidgeest, Ernst, van der Weerd, Louise, Mei, Hailiang, Baelde, Hans J, Peters, Dorien J M

“…Initial cysts that are formed upon Pkd1 loss in mice impose persistent stress on surrounding tissue and trigger a cystic snowball effect, in which local…”
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Whole-genome profiling of primary cutaneous anaplastic large cell lymphoma by Bastidas Torres, Armando N., Melchers, Rutger C., Van Grieken, Liana, Out-Luiting, Jacoba J., Mei, Hailiang, Agaser, Cedrick, Kuipers, Thomas B., Quint, Koen D., Willemze, Rein, Vermeer, Maarten H., Tensen, Cornelis P.

“…Primary cutaneous anaplastic large cell lymphoma (pcALCL), a hematological neoplasm caused by skin-homing CD30+ malignant T cells, is part of the spectrum of…”
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Differential optineurin expression controls TGFβ signaling and is a key determinant for metastasis of triple negative breast cancer by Liu, Sijia, Dinther, Maarten, Hagenaars, Sophie C., Gu, Yuanzhuo, Kuipers, Thomas B., Mei, Hailiang, Gomez‐Puerto, Maria Catalina, Mesker, Wilma E., Dijke, Peter

“…Triple‐negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat due to its aggressive characteristics and low response to the…”
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PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells by Prior, Robert, Silva, Alessio, Vangansewinkel, Tim, Idkowiak, Jakub, Tharkeshwar, Arun Kumar, Hellings, Tom P, Michailidou, Iliana, Vreijling, Jeroen, Loos, Maarten, Koopmans, Bastijn, Vlek, Nina, Agaser, Cedrick, Kuipers, Thomas B, Michiels, Christine, Rossaert, Elisabeth, Verschoren, Stijn, Vermeire, Wendy, de Laat, Vincent, Dehairs, Jonas, Eggermont, Kristel, van den Biggelaar, Diede, Bademosi, Adekunle T, Meunier, Frederic A, vandeVen, Martin, Van Damme, Philip, Mei, Hailiang, Swinnen, Johannes V, Lambrichts, Ivo, Baas, Frank, Fluiter, Kees, Wolfs, Esther, Van Den Bosch, Ludo

“…Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy caused by a 1.5 Mb tandem duplication of chromosome 17…”
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Kidney temperature course during living organ procurement and transplantation by Kuipers, Thomas G J, Hellegering, Joyce, El Moumni, Mostafa, Krikke, Christina, Haveman, Jan Willem, Berger, Stefan P, Leuvenink, Henri G, Pol, Robert A

“…Little is known about the actual kidney graft temperature during the 2nd warm ischemia time (WIT2). We aimed to determine the actual temperature course of the…”
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Causative mechanisms and clinical impact of immunoglobulin deficiencies in ataxia telangiectasia by Takada, Sanami, Weitering, Thomas J., van Os, Nienke J.H., Du, Likun, Pico-Knijnenburg, Ingrid, Kuipers, Thomas B., Mei, Hailiang, Salzer, Elisabeth, Willemsen, Michèl A.A.P., Weemaes, Corry M.R., Pan-Hammarstrom, Qiang, van der Burg, Mirjam

“…[Display omitted] Ataxia telangiectasia (AT) is characterized by cerebellar ataxia, telangiectasia, immunodeficiency, and increased cancer susceptibility and…”
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Transcriptional and functional profiling identifies inflammation and endothelial-to-mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of endothelial colony forming cells by Laan, Sebastiaan N.J., de Boer, Suzan, Dirven, Richard J., van Moort, Iris, Kuipers, Thomas B., Mei, Hailiang, Bierings, Ruben, Eikenboom, Jeroen, Brands, Martijn, Koopman, Sjoerd, Bukkems, Laura, Cloesmeijer, Michael, Janssen, Alexander, Fijnvandraat, Karin, Gouw, Samantha, Mathôt, Ron, Haverman, Lotte, van den Akker, Emile, van den Biggelaar, Maartje, de Haas, Masja, Meijer, Sander, Voorberg, Jan, Del Castillo Alferez, Jessica, Zhang, Huan, Boender, Johan, Meijer, Stephan, Meijer, Karina, de Jong, Sean, Goedhart, Geertje, van der Bom, Anske, Bos, Mettine, Eikenboom, Jeroen, van der Meer, Felix, Laan, Sebastiaan, Schols, Saskia, Bierings, Ruben, Burdorf, Lex, Cnossen, Marjon, Hazelzet, Jan, Huisman, Elise, Kruip, Marieke, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, van Moort, Iris, Polinder, Suzanne, Reitsma, Simone, Roest, Eliza, Arisz, Ryanne, Romano, Lorenzo, Al Arashi, Wala, van Hoorn, Shannon, Goedhart, Tine, Mussert, Caroline, Prameyllawati, Diaz, Uyl, Carin, Jansen, Nathalie, Fischer, Kathelijn, Ploos van Amstel, Hans Kristian, Urbanus, Rolf, Zivkovic, Minka, Bredenoord, Annelien, van der Graaf, Rieke, Baas, Lieke, Schutgens, Roger, Driessens, Mariëtte

“…Endothelial colony-forming cells (ECFCs) derived from patients can be used to investigate pathogenic mechanisms of vascular diseases like von Willebrand…”
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The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality by Hajmousa, Ghazaleh, de Almeida, Rodrigo Coutinho, Bloks, Niek, Ruiz, Alejandro Rodríguez, Bouma, Marga, Slieker, Roderick, Kuipers, Thomas B, Nelissen, Rob G H H, Ito, Keita, Freund, Christian, Ramos, Yolande F M, Meulenbelt, Ingrid

“…Lack of insight into factors that determine purity and quality of human iPSC (hiPSC)-derived neo-cartilage precludes applications of this powerful technology…”
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Characterizing the secretome of licensed hiPSC-derived MSCs by Ramos, Yolande F M, Tertel, Tobias, Shaw, Georgina, Staubach, Simon, de Almeida, Rodrigo Coutinho, Suchiman, Eka, Kuipers, Thomas B, Mei, Hailiang, Barry, Frank, Murphy, Mary, Giebel, Bernd, Meulenbelt, Ingrid

“…Although mesenchymal stromal cells (MSCs) from primary tissues have been successfully applied in the clinic, their expansion capabilities are limited and…”
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Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex by Gytz Olesen, Heidi, Michailidou, Iliana, Zelek, Wioleta M., Vreijling, Jeroen, Ruizendaal, Patrick, de Klein, Ferry, Marquart, J. Arnoud, Kuipers, Thomas B., Mei, Hailiang, Zhang, Yuchun, Ahasan, Muhammad, Johnson, Krista K., Wang, Yi, Morgan, B. Paul, van Dijk, Marcus, Fluiter, Kees, Andersen, Gregers Rom, Baas, Frank

“…Abstract Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads…”
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RNA-sequencing to discover genes and signaling pathways associated with venous thromboembolism in glioblastoma patients: A case-control study by Kapteijn, Maaike Y., Lanting, Vincent R., Kaptein, Fleur H.J., Guman, Noori A.M., Laghmani, El Houari, Kuipers, Thomas B., Mei, Hailiang, Goeman, Jelle J., Mulder, Frits I., van Duinen, Sjoerd G., Taphoorn, Martin J.B., Dirven, Linda, Broekman, Marike L.D., van Es, Nick, Klok, Frederikus A., Koekkoek, Johan A.F., Versteeg, Henri H., Buijs, Jeroen T.

“…BACKGROUNDGlioblastoma patients are at high risk of developing venous thromboembolism (VTE). Tumor-intrinsic features are considered to play a role, but the…”
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The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22 by Michailidou, Iliana, Vreijling, Jeroen, Rumpf, Matthijs, Loos, Maarten, Koopmans, Bastijn, Vlek, Nina, Straat, Nina, Agaser, Cedrick, Kuipers, Thomas B., Mei, Hailiang, Baas, Frank, Fluiter, Kees

“…Charcot-Marie-Tooth disease type 1A (CMT1A) is the most prevalent hereditary demyelinating neuropathy. This autosomal, dominantly inherited disease is caused…”
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Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins by Todtenhaupt, Pia, Kuipers, Thomas B, Dijkstra, Kyra L, Voortman, Lenard M, Franken, Laura A, Spekman, Jip A, Jonkman, Thomas H, Groene, Sophie G, Roest, Arno Aw, Haak, Monique C, Verweij, EJoanne T, van Pel, Melissa, Lopriore, Enrico, Heijmans, Bastiaan T, van der Meeren, Lotte E

“…The human umbilical cord (hUC) is the lifeline that connects the fetus to the mother. Hypercoiling of the hUC is associated with pre- and perinatal morbidity…”
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Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease by Kanhai, Anish A., Sánchez-López, Elena, Kuipers, Thomas B., van Klinken, Jan B., Dijkstra, Kyra L., van der Veen, Inge, Baelde, Hans J., Song, Xuewen, Pei, York, Mei, Hailiang, Leonhard, Wouter N., Mayboroda, Oleg A., Peters, Dorien J.M.

“…Metabolic reprogramming is a driver of autosomal dominant polycystic kidney disease (ADPKD) progression and a potential therapeutic intervention route. We…”
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Full-Thickness Resection With Myocutaneous Flap Reconstruction for Locally Recurrent Breast Cancer by Friedel, Godehard, MD, FETCS, Kuipers, Thomas, MD, Dippon, Jürgen, PhD, Al-Kammash, Fawaz, MD, Walles, Thorsten, MD, Kyriss, Thomas, MD, Veit, Stefanie, MD, Greulich, Michael, MD, Steger, Volker, MD

“…Background Despite available recommendations, therapeutic procedures of locally recurrent breast cancer are very different. This retrospective study presents…”
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