Search Results - "KUHN, Michaela"

Molecular Physiology of Membrane Guanylyl Cyclase Receptors by Kuhn, Michaela

“…cGMP controls many cellular functions ranging from growth, viability, and differentiation to contractility, secretion, and ion transport. The mammalian genome…”
Get full text

Endothelial actions of atrial and B‐type natriuretic peptides by Kuhn, Michaela

“…The cardiac hormone atrial natriuretic peptide (ANP) is critically involved in the maintenance of arterial blood pressure and intravascular volume homeostasis…”
Get full text

Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases by Kuhn, Michaela

“…Besides soluble guanylyl cyclase (GC), the receptor for NO, there are seven plasma membrane forms of guanylyl cyclase (GC) receptors, enzymes that synthesize…”
Get more information

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors by Alexander, Stephen PH, Fabbro, Doriano, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Beuve, Annie, Brouckaert, Peter, Bryant, Clare, Burnett, John C., Farndale, Richard W., Friebe, Andreas, Garthwaite, John, Hobbs, Adrian J., Jarvis, Gavin E., Kuhn, Michaela, MacEwan, David, Monie, Tom P., Papapetropoulos, Andreas, Potter, Lincoln R., Schmidt, Harald H.H.W., Szabo, Csaba, Waldman, Scott A.

“…The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
Get full text

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure by Špiranec, Katarina, Chen, Wen, Werner, Franziska, Nikolaev, Viacheslav O, Naruke, Takashi, Koch, Franziska, Werner, Andrea, Eder-Negrin, Petra, Diéguez-Hurtado, Rodrigo, Adams, Ralf H, Baba, Hideo A, Schmidt, Hannes, Schuh, Kai, Skryabin, Boris V, Movahedi, Kiavash, Schweda, Frank, Kuhn, Michaela

“…BACKGROUND:Peripheral vascular resistance has a major impact on arterial blood pressure levels. Endothelial C-type natriuretic peptide (CNP) participates in…”
Get full text

Gender Inequality in the Cocoa Supply Chain: Evidence from Smallholder Production in Ecuador and Uganda by Kuhn, Michaela, Tennhardt, Lina, Lazzarini, Gianna A.

“…•Female farmers are highly involved in cocoa production, but their roles and decision-making power differ between male and female managed farms.•Gender-based…”
Get full text

Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction by Chen, Wen, Spitzl, Annett, Mathes, Denise, Nikolaev, Viacheslav O, Werner, Franziska, Weirather, Johannes, Špiranec, Katarina, Röck, Katharina, Fischer, Jens W, Kämmerer, Ulrike, Stegner, David, Baba, Hideo A, Hofmann, Ulrich, Frantz, Stefan, Kuhn, Michaela

“…RATIONALE:In patients after acute myocardial infarction (AMI), the initial extent of necrosis and inflammation determine clinical outcome. One early event in…”
Get full text

Auto/Paracrine C-Type Natriuretic Peptide/Cyclic GMP Signaling Prevents Endothelial Dysfunction by Werner, Franziska, Naruke, Takashi, Sülzenbrück, Lydia, Schäfer, Sarah, Rösch, Melanie, Völker, Katharina, Krebes, Lisa, Abeßer, Marco, Möllmann, Dorothe, Baba, Hideo A, Schweda, Frank, Zernecke, Alma, Kuhn, Michaela

“…Endothelial dysfunction is cause and consequence of cardiovascular diseases. The endothelial hormone C-type natriuretic peptide (CNP) regulates vascular tone…”
Get full text

Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function by Staffel, Janina, Valletta, Daniela, Federlein, Anna, Ehm, Katharina, Volkmann, Regine, Füchsl, Andrea M, Witzgall, Ralph, Kuhn, Michaela, Schweda, Frank

“…The cardiac natriuretic peptides (NPs), atrial NP and B-type NP, regulate fluid homeostasis and arterial BP through renal actions involving increased GFR and…”
Get full text

Empagliflozin Reduces Renal Hyperfiltration in Response to Uninephrectomy, but Is Not Nephroprotective in UNx/DOCA/Salt Mouse Models by Tauber, Philipp, Sinha, Frederick, Berger, Raffaela S, Gronwald, Wolfram, Dettmer, Katja, Kuhn, Michaela, Trum, Maximilian, Maier, Lars S, Wagner, Stefan, Schweda, Frank

“…Large-scale clinical outcome studies demonstrated the efficacy of SGLT2 inhibitors in patients with type II diabetes. Besides their therapeutic efficacy in…”
Get full text

Transgenic Mice for Real-Time Visualization of cGMP in Intact Adult Cardiomyocytes by Götz, Konrad R, Sprenger, Julia U, Perera, Ruwan K, Steinbrecher, Julia H, Lehnart, Stephan E, Kuhn, Michaela, Gorelik, Julia, Balligand, Jean-Luc, Nikolaev, Viacheslav O

“…RATIONALE:3′,5′-Cyclic guanosine monophosphate (cGMP) is an important second messenger that regulates cardiac contractility and protects the heart from…”
Get full text

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia by Bork, Nadja I., Kuret, Anna, Cruz Santos, Melanie, Molina, Cristina E., Reiter, Beate, Reichenspurner, Hermann, Friebe, Andreas, Skryabin, Boris V., Rozhdestvensky, Timofey S., Kuhn, Michaela, Lukowski, Robert, Nikolaev, Viacheslav O.

“…3′,5′-cyclic guanosine monophosphate (cGMP) is a druggable second messenger regulating cell growth and survival in a plethora of cells and disease states, many…”
Get full text

C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness by Michel, Konstanze, Herwig, Melissa, Werner, Franziska, Špiranec Spes, Katarina, Abeßer, Marco, Schuh, Kai, Dabral, Swati, Mügge, Andreas, Baba, Hideo A, Skryabin, Boris V, Hamdani, Nazha, Kuhn, Michaela

“…Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases…”
Get full text

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss by Marchetta, Philine, Möhrle, Dorit, Eckert, Philipp, Reimann, Katrin, Wolter, Steffen, Tolone, Arianna, Lang, Isabelle, Wolters, Markus, Feil, Robert, Engel, Jutta, Paquet-Durand, François, Kuhn, Michaela, Knipper, Marlies, Rüttiger, Lukas

“…In the inner ear, cyclic guanosine monophosphate (cGMP) signaling has been described as facilitating otoprotection, which was previously observed through…”
Get full text

Atrial Natriuretic Peptide–Mediated Inhibition of Microcirculatory Endothelial Ca2+ and Permeability Response to Histamine Involves cGMP-Dependent Protein Kinase I and TRPC6 Channels by Chen, Wen, Oberwinkler, Heike, Werner, Franziska, Ganer, Birgit, Nakagawa, Hitoshi, Feil, Robert, Hofmann, Franz, Schlossmann, Jens, Dietrich, Alexander, Gudermann, Thomas, Nishida, Motohiro, Del Galdo, Sabrina, Wieland, Thomas, Kuhn, Michaela

“…OBJECTIVE—Histamine increases microvascular endothelial leakage by activation of complex calcium-dependent and -independent signaling pathways. Atrial…”
Get full text

C-type natriuretic peptide/cGMP/FoxO3 signaling attenuates hyperproliferation of pericytes from patients with pulmonary arterial hypertension by Dabral, Swati, Noh, Minhee, Werner, Franziska, Krebes, Lisa, Völker, Katharina, Maier, Christopher, Aleksic, Ivan, Novoyatleva, Tatyana, Hadzic, Stefan, Schermuly, Ralph Theo, Perez, Vinicio A. de Jesus, Kuhn, Michaela

“…Pericyte dysfunction, with excessive migration, hyperproliferation, and differentiation into smooth muscle-like cells contributes to vascular remodeling in…”
Get full text

Keeps Cardiac Pericytes in Good Shape: Regulator of G-Protein Signaling-5 by Kuhn, Michaela

Get full text

Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralocorticoid receptor activation by Nakagawa, Hitoshi, Oberwinkler, Heike, Nikolaev, Viacheslav O, Gaßner, Birgit, Umbenhauer, Sandra, Wagner, Helga, Saito, Yoshihiko, Baba, Hideo A, Frantz, Stefan, Kuhn, Michaela

“…The endocrine balance between atrial natriuretic peptide (ANP) and the renin-angiotensin-aldosterone system is critical for the maintenance of arterial blood…”
Get full text

The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice by Kuhn, Michaela, Völker, Katharina, Schwarz, Kristine, Carbajo-Lozoya, Javier, Flögel, Ulrich, Jacoby, Christoph, Stypmann, Jörg, van Eickels, Martin, Gambaryan, Stepan, Hartmann, Michael, Werner, Matthias, Wieland, Thomas, Schrader, Jürgen, Baba, Hideo A

“…Cardiac atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) modulate blood pressure and volume by activation of the receptor guanylyl…”
Get full text

Cardiac and intestinal natriuretic peptides: Insights from genetically modified mice by Kuhn, Michaela

“…Since the original discovery of atrial natriuretic peptide (ANP) more than two decades ago, the application of gene targeting technology in mice has provided…”
Get full text