Search Results - "KUHN, Lars T"

In-Cell NMR: Analysis of Protein-Small Molecule Interactions, Metabolic Processes, and Protein Phosphorylation by Kumar, Amit, Kuhn, Lars T, Balbach, Jochen

“…Nuclear magnetic resonance (NMR) spectroscopy enables the non-invasive observation of biochemical processes, in living cells, at comparably high spectral and…”
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Fully Collapsed Imploded Cryptophanes in Solution and in the Solid State by Thorp‐Greenwood, Flora L., Howard, Mark J., Kuhn, Lars T., Hardie, Michaele J.

“…Cryptophanes with flexible linkers derived from (±)‐tris‐(4‐formyl‐phenyl)‐cyclotriguaiacylene with either bisoxydi(ethylamine) or bis(aminopropyl)ether were…”
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A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein by HUN MOK, K, KUHN, Lars T, GOEZ, Martin, DAY, Iain J, LIN, Jasper C, ANDERSEN, Niels H, HORE, P. J

“…Insights into the conformational passage of a polypeptide chain across its free energy landscape have come from the judicious combination of experimental…”
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Atomic-level structure characterization of an ultrafast folding mini-protein denatured state by Rogne, Per, Ozdowy, Przemysław, Richter, Christian, Saxena, Krishna, Schwalbe, Harald, Kuhn, Lars T

“…Atomic-level analyses of non-native protein ensembles constitute an important aspect of protein folding studies to reach a more complete understanding of how…”
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A Cu2+ complex induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53 by Kumar, Amit, Kuhn, Lars T., Balbach, Jochen

“…Papillomavirus oncoprotein E6 is a critical factor in the modulation of cervical cancer in humans. At the molecular level, formation of the E6–E6AP‐p53 ternary…”
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Hyperpolarization-Enhanced NMR Spectroscopy of Unaltered Biofluids Using Photo-CIDNP by Kuhn, Lars T., Weber, Stefan, Bargon, Joachim, Parella, Teodor, Pérez-Trujillo, Míriam

“…The direct and unambiguous detection and identification of individual metabolite molecules present in complex biological mixtures constitute a major challenge…”
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A Cu 2+ complex induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53 by Kumar, Amit, Kuhn, Lars T, Balbach, Jochen

“…Papillomavirus oncoprotein E6 is a critical factor in the modulation of cervical cancer in humans. At the molecular level, formation of the E6-E6AP-p53 ternary…”
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Simultaneous Enantiospecific Detection of Multiple Compounds in Mixtures using NMR Spectroscopy by Kuhn, Lars T., Motiram‐Corral, Kumar, Athersuch, Toby J., Parella, Teodor, Pérez‐Trujillo, Míriam

“…Chirality plays a fundamental role in nature, but its detection and quantification still face many limitations. To date, the enantiospecific analysis of…”
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Similarity of SABRE field dependence in chemically different substrates by Dücker, Eibe B., Kuhn, Lars T., Münnemann, Kerstin, Griesinger, Christian

“…[Display omitted] ► Several pyrazole derivatives were examined using the SABRE hyperpolarization method. ► The field dependence of the enhancement depends only…”
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NMR-aided differentiation of enantiomers: Signal enantioresolution by Pérez-Trujillo, Míriam, Parella, Teodor, Kuhn, Lars T.

“…[Display omitted] •The concept and importance of NMR signal enantioresolution is described.•The enantioresolution quotient E for its measurement is…”
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Simultaneous (1)H and (13)C NMR enantiodifferentiation from highly-resolved pure shift HSQC spectra by Pérez-Trujillo, Míriam, Castañar, Laura, Monteagudo, Eva, Kuhn, Lars T, Nolis, Pau, Virgili, Albert, Williamson, R Thomas, Parella, Teodor

“…NMR enantiodifferentiation studies are greatly improved by the simultaneous determination of (1)H and (13)C chemical shift differences through the analysis of…”
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Photo-CIDNP NMR spectroscopy of amino acids and proteins by Kuhn, Lars T

“…Photo-chemically induced dynamic nuclear polarization (CIDNP) is a nuclear magnetic resonance (NMR) phenomenon which, among other things, is exploited to…”
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Determining the Absolute Configuration of (+)-Mefloquine HCl, the Side-Effect-Reducing Enantiomer of the Antimalaria Drug Lariam by Schmidt, Manuel, Sun, Han, Rogne, Per, Scriba, Gerhard K. E, Griesinger, Christian, Kuhn, Lars T, Reinscheid, Uwe M

“…Even though the important antimalaria drug rac-erythro-mefloquine HCl has been on the market as Lariam for decades, the absolute configurations of its…”
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Protein Surface Mimetics: Understanding How Ruthenium Tris(Bipyridines) Interact with Proteins by Hewitt, Sarah H., Filby, Maria H., Hayes, Ed, Kuhn, Lars T., Kalverda, Arnout P., Webb, Michael E., Wilson, Andrew J.

“…Protein surface mimetics achieve high‐affinity binding by exploiting a scaffold to project binding groups over a large area of solvent‐exposed protein surface…”
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Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs by Schnieders, Robbin, Richter, Christian, Warhaut, Sven, de Jesus, Vanessa, Keyhani, Sara, Duchardt-Ferner, Elke, Keller, Heiko, Wöhnert, Jens, Kuhn, Lars T., Breeze, Alexander L., Bermel, Wolfgang, Schwalbe, Harald, Fürtig, Boris

“…Recently, 15 N-detected multidimensional NMR experiments have been introduced for the investigation of proteins. Utilization of the slow transverse relaxation…”
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Cover Picture: Protein Surface Mimetics: Understanding How Ruthenium Tris(Bipyridines) Interact with Proteins (ChemBioChem 2/2017) by Hewitt, Sarah H., Filby, Maria H., Hayes, Ed, Kuhn, Lars T., Kalverda, Arnout P., Webb, Michael E., Wilson, Andrew J.

“…The cover picture shows competitive inhibition of the cytochrome c/cytochrome c peroxidase interaction by highly functionalized ruthenium(II) tris(bipyridine)…”
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Simultaner enantiospezifischer Nachweis mehrerer Verbindungen in Mischungen mittels NMR‐Spektroskopie by Kuhn, Lars T., Motiram‐Corral, Kumar, Athersuch, Toby J., Parella, Teodor, Pérez‐Trujillo, Míriam

“…Das Konzept der Chiralität spielt in der Natur eine fundamentale Rolle, obwohl sowohl ihr analytischer Nachweis als auch ihre Quantifizierung nach wie vor…”
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Transfer of Parahydrogen-Induced Hyperpolarization to 19F by Kuhn, Lars T, Bommerich, Ute, Bargon, Joachim

“…Homogeneous hydrogenations of unsaturated substrates with parahydrogen yield strong NMR signal enhancements of the transferred 1H nuclei if the symmetry of H2…”
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Photo-CIDNP Studies of Hydroxy Ketones and Higher-Molecular-Weight Systems by Bargon, Joachim, Kuhn, Lars T.

“…In situ NMR spectroscopy can be applied to investigate chemical reactions during which free radicals occur as intermediates. In chemical systems of low…”
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H and 13C Hyperfine Coupling Constants of the Tryptophanyl Cation Radical in Aqueous Solution from Microsecond Time-Resolved CIDNP by Kiryutin, Alexey S, Morozova, Olga B, Kuhn, Lars T, Yurkovskaya, Alexandra V, Hore, P. J

“…Relative values of the 1H and 13C isotropic hyperfine couplings in the cationic oxidized tryptophan radical TrpH•+ in aqueous solution are determined. The data…”
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