Search Results - "KUGLIK, P"

Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance by Kubiczkova, Lenka, Kryukov, Fedor, Slaby, Ondrej, Dementyeva, Elena, Jarkovsky, Jiri, Nekvindova, Jana, Radova, Lenka, Greslikova, Henrieta, Kuglik, Petr, Vetesnikova, Eva, Pour, Ludek, Adam, Zdenek, Sevcikova, Sabina, Hajek, Roman

“…Multiple myeloma still remains incurable in the majority of cases prompting a further search for new and better prognostic markers. Emerging evidence has…”
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TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations by Zenz, T, Vollmer, D, Trbusek, M, Smardova, J, Benner, A, Soussi, T, Helfrich, H, Heuberger, M, Hoth, P, Fuge, M, Denzel, T, Häbe, S, Malcikova, J, Kuglik, P, Truong, S, Patten, N, Wu, L, Oscier, D, Ibbotson, R, Gardiner, A, Tracy, I, Lin, K, Pettitt, A, Pospisilova, S, Mayer, J, Hallek, M, Döhner, H, Stilgenbauer, S

“…The TP53 mutation profile in chronic lymphocytic leukemia (CLL) and the correlation of TP53 mutations with allele status or associated molecular genetics are…”
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8009 POSTER The Determination of the Gene Amplification for Human Telomerase (hTERC) in Cervical Intraepithelial Neoplasia and Cervical Carcinoma in the Czech Republic by Moukova, L, Kuglik, P, Vranova, V, Slamova, I, Kissova, M

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Detection of oncogenic mutations in cervical carcinoma using method High Resolution Melting (HRM) by Wayhelova, M, Mikulasova, A, Smetana, J, Vallova, V, Blazkova, D, Filkova, H, Moukova, L, Kuglik, P

“…Oncogenic mutations in proto-oncogenes and tumor suppressor genes represent one of key events in cancerogenesis. In this study, we analysed mutation status in…”
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P-17 High resolution oligonucleotide array-CGH method for preimplantation genetic screening: preclinical validation and first clinical results by Vallova, V, Paralova, D, Smetana, J, Mikulasova, A, Hubinka, V, Slivkova, L, Zaoralova, R, Ulicny, B, Machac, S, Koudelka, M, Kuglik, P

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Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH by Smetana, J, Dementyeva, E, Kryukov, F, Nemec, P, Greslikova, H, Kupska, R, Mikulasova, A, Ihnatova, I, Hajek, R, Kuglik, P

“…Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely…”
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Analysis of chromosomal aberrations in patients with mental retardation using the array-CGH technique: a single Czech centre experience by Zrnova, E, Vranova, V, Slamova, I, Gaillyova, R, Kuglik, P

“…Submicroscopic structural chromosomal aberrations (microduplications and microdeletions) are believed to be common causes of mental retardation. These…”
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Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma by Dementyeva, E, Nemec, P, Kryukov, F, Muthu Raja, K.R, Smetana, J, Zaoralova, R, Greslikova, H, Kupska, R, Kuglik, P, Hajek, R

“…Abstract Centrosome amplification (CA) as a potential marker of mitotic disruptions in multiple myeloma (MM) was investigated in two populations of B-cell…”
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Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment by Trbusek, M, Malcikova, J, Smardova, J, Kuhrova, V, Mentzlova, D, Francova, H, Bukovska, S, Svitakova, M, Kuglik, P, Linkova, V, Doubek, M, Brychtova, Y, Zacal, J, Kujickova, J, Pospisilova, S, Dvorakova, D, Vorlicek, J, Mayer, J

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Unique Combination of 22q11 and 14qter Microdeletion Syndromes Detected Using Oligonucleotide Array-CGH by Zrnová, E., Vranová, V., Šoukalová, J., Slámová, I., Vilémová, M., Gaillyová, R., Kuglík, P.

“…We report an infant with a unique combination of 22q11 deletion syndrome and 14q terminal deletion syndrome. The proband had clinical symptoms compatible with…”
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Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation by Greslikova, H, Zaoralova, R, Filkova, H, Nemec, P, Oltova, A, Kupska, R, Rudolecka, P, Smetana, J, Pour, L, Zahradova, L, Krejci, M, Buchler, T, Adam, Z, Hajek, R, Kuglik, P

“…Malignant plasma cells in multiple myeloma (MM) are frequently characterized by complex karyotypes and chromosome instability. These cytogenetic changes are…”
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Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology by Necesalová, E, Vranová, V, Kuglík, P, Cejpek, P, Jarosová, M, Pesáková, M, Relichová, J, Veselská, R

“…Glioblastoma multiforme (GBM) is the most common as well as the most aggressive type of primary brain tumor of astrocytic origin in adults. GBM is…”
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The optimization of sample treatment for spectral karyotyping with applications for human tumour cells by Loja, T, Kuglik, P, Oltova, A, Smuharova, P, Zitterbart, K, Bajciova, V, Veselska, R

“…Spectral karyotyping (SKY) represents an important tool for the investigation of the complex chromosomal rearrangements (CCRs) in many human malignancies which…”
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O22 Genetic lesions in multiple myeloma: prognostic and predictive significance in the era of the new drugs by Hajek, R, Kuglik, P, Zaoralova, R, Greslikova, H, Nemec, P, Smejkalova, J

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159 Selection and clinical relevance of monoallelic and biallelic TP53 defects in chronic lymphocytic leukemia by Malcikova, J, Trbusek, M, Smardova, J, Rocnova, L, Tichy, B, Kuglik, P, Brychtova, Y, Doubek, M, Mayer, J, Pospisilova, S

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P140 Prognostic impact of 1q21 amplification in patients with multiple myeloma treated by velcade, thalidomide and any conventional chemotherapy by Nemec, P, Kuglik, P, Vranova, V, Zaoralova, R, Greslikova, H, Oltova, A, Filkova, H, Vidlakova, P, Smejkalova, J, Hajek, R

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O58 Correlation between chromosomal aberrations and standard prognostic factors in patients with multiple myeloma undergoing autologous stem cell transplantation by Greslikova, H, Kuglik, P, Filkova, H, Oltova, A, Adam, Z, Krivanova, A, Pour, L, Smejkalova, J, Krejci, M, Hajek, R

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Efficacy of high-resolution comparative genomic hybridization (HR-CGH) in detection of chromosomal abnormalities in children with acute leukaemia by Vranova, V, Mentzlova, D, Oltova, A, Linkova, V, Zezulkova, D, Filkova, H, Mendelova, D, Sterba, J, Kuglik, P

“…The efficient detection of chromosomal aberrations in childhood acute leukaemias presents a significant component in the diagnostics of this frequent malignant…”
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P141 Do the “new drugs” antagonize the impact of unfavourable cytogenetic markers in multiple myeloma? by Zaoralova, R, Greslikova, H, Filkova, H, Nemec, P, Kuglik, P, Oltova, A, Pour, L, Adam, Z, Smejkalova, J, Krivanova, A, Krejci, M, Hajek, R

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Expanding application of next generation sequencing in clinical laboratory by Smetana, J., Wayhelova, M., Vallova, V., Zrnova, E., Synkova, I., Vaňásková, M., Vinohradská, J., Ošťádalová, E., Valášková, I., Kuglik, P.

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