Search Results - "KUGEL, Curtis H"

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3 by Abel, Ethan V, Basile, Kevin J, Kugel, 3rd, Curtis H, Witkiewicz, Agnieszka K, Le, Kaitlyn, Amaravadi, Ravi K, Karakousis, Giorgos C, Xu, Xiaowei, Xu, Wei, Schuchter, Lynn M, Lee, Jason B, Ertel, Adam, Fortina, Paolo, Aplin, Andrew E

“…The mechanisms underlying adaptive resistance of melanoma to targeted therapies remain unclear. By combining ChIP sequencing with microarray-based gene…”
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Adaptive resistance to RAF inhibitors in melanoma by Kugel III, Curtis H., Aplin, Andrew E.

“…Summary The discovery of activating mutations in BRAF at high frequency in cutaneous melanoma opened the door to new treatment options, which have resulted in…”
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The Wnts of change: How Wnts regulate phenotype switching in melanoma by Webster, Marie R., Kugel, Curtis H., Weeraratna, Ashani T.

“…The outgrowth of metastatic and therapy-resistant subpopulations in cancer remains a critical barrier for the successful treatment of this disease. In…”
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Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility by Kaur, Amanpreet, Ecker, Brett L, Douglass, Stephen M, Kugel, 3rd, Curtis H, Webster, Marie R, Almeida, Filipe V, Somasundaram, Rajasekharan, Hayden, James, Ban, Ehsan, Ahmadzadeh, Hossein, Franco-Barraza, Janusz, Shah, Neelima, Mellis, Ian A, Keeney, Frederick, Kossenkov, Andrew, Tang, Hsin-Yao, Yin, Xiangfan, Liu, Qin, Xu, Xiaowei, Fane, Mitchell, Brafford, Patricia, Herlyn, Meenhard, Speicher, David W, Wargo, Jennifer A, Tetzlaff, Michael T, Haydu, Lauren E, Raj, Arjun, Shenoy, Vivek, Cukierman, Edna, Weeraratna, Ashani T

“…Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM)…”
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CADM1 is a TWIST1-regulated suppressor of invasion and survival by Hartsough, Edward J., Weiss, Michele B., Heilman, Shea A., Purwin, Timothy J., Kugel, Curtis H., Rosenbaum, Sheera R., Erkes, Dan A., Tiago, Manoela, HooKim, Kim, Chervoneva, Inna, Aplin, Andrew E.

“…Metastatic cancer remains a clinical challenge; however, patients diagnosed prior to metastatic dissemination have a good prognosis. The transcription factor,…”
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Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho by Behera, Reeti, Kaur, Amanpreet, Webster, Marie R, Kim, Suyeon, Ndoye, Abibatou, Kugel, 3rd, Curtis H, Alicea, Gretchen M, Wang, Joshua, Ghosh, Kanad, Cheng, Phil, Lisanti, Sofia, Marchbank, Katie, Dang, Vanessa, Levesque, Mitchell, Dummer, Reinhard, Xu, Xiaowei, Herlyn, Meenhard, Aplin, Andrew E, Roesch, Alexander, Caino, Cecilia, Altieri, Dario C, Weeraratna, Ashani T

“…Aging is a poor prognostic factor for melanoma. We have shown that melanoma cells in an aged microenvironment are more resistant to targeted therapy than…”
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SHOC2 and CRAF Mediate ERK1/2 Reactivation in Mutant NRAS-mediated Resistance to RAF Inhibitor by Kaplan, Fred M., Kugel, Curtis H., Dadpey, Neda, Shao, Yongping, Abel, Ethan V., Aplin, Andrew E.

“…ERK1/2 signaling is frequently dysregulated in tumors through BRAF mutation. Targeting mutant BRAF with vemurafenib frequently elicits therapeutic responses;…”
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Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2 by Alicea, Gretchen M, Rebecca, Vito W, Goldman, Aaron R, Fane, Mitchell E, Douglass, Stephen M, Behera, Reeti, Webster, Marie R, Kugel, 3rd, Curtis H, Ecker, Brett L, Caino, M Cecilia, Kossenkov, Andrew V, Tang, Hsin-Yao, Frederick, Dennie T, Flaherty, Keith T, Xu, Xiaowei, Liu, Qin, Gabrilovich, Dmitry I, Herlyn, Meenhard, Blair, Ian A, Schug, Zachary T, Speicher, David W, Weeraratna, Ashani T

“…Older patients with melanoma (>50 years old) have poorer prognoses and response rates to targeted therapy compared with young patients (<50 years old), which…”
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Myeloid-Derived Suppressor Cells Are a Major Source of Wnt5A in the Melanoma Microenvironment and Depend on Wnt5A for Full Suppressive Activity by Douglass, Stephen M, Fane, Mitchell E, Sanseviero, Emilio, Ecker, Brett L, Kugel, 3rd, Curtis H, Behera, Reeti, Kumar, Vinit, Tcyganov, Evgenii N, Yin, Xiangfan, Liu, Qin, Chhabra, Yash, Alicea, Gretchen M, Kuruvilla, Rejji, Gabrilovich, Dmitry I, Weeraratna, Ashani T

“…Metastatic dissemination remains a significant barrier to successful therapy for melanoma. Wnt5A is a potent driver of invasion in melanoma and is believed to…”
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Function-Blocking ERBB3 Antibody Inhibits the Adaptive Response to RAF Inhibitor by KUGEL, Curtis H, HARTSOUGH, Edward J, DAVIES, Michael A, SETIADY, Yulius Y, APLIN, Andrew E

“…ERBB3/HER3 expression and signaling are upregulated in mutant BRAF melanoma as an adaptive, prosurvival response to FDA-approved RAF inhibitors. Because…”
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Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo by Hartsough, Edward J, Kugel, 3rd, Curtis H, Vido, Michael J, Berger, Adam C, Purwin, Timothy J, Goldberg, Allison, Davies, Michael A, Schiewer, Matthew J, Knudsen, Karen E, Bollag, Gideon, Aplin, Andrew E

“…FDA-approved BRAF inhibitors produce high response rates and improve overall survival in patients with BRAF V600E/K-mutant melanoma, but are linked to…”
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ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma by Ndoye, Abibatou, Budina-Kolomets, Anna, Kugel, 3rd, Curtis H, Webster, Marie R, Kaur, Amanpreet, Behera, Reeti, Rebecca, Vito W, Li, Ling, Brafford, Patricia A, Liu, Qin, Gopal, Y N Vashisht, Davies, Michael A, Mills, Gordon B, Xu, Xiaowei, Wu, Hong, Herlyn, Meenhard, Nicastri, Michael C, Winkler, Jeffrey D, Soengas, Maria S, Amaravadi, Ravi K, Murphy, Maureen E, Weeraratna, Ashani T

“…Autophagy mediates resistance to various anticancer agents. In melanoma, resistance to targeted therapy has been linked to expression of Wnt5A, an intrinsic…”
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When metastasis ‘Spns’ out of control: Coverage of ‘Genome‐wide in vivo screen identifies novel host regulators of metastatic colonization’ by Webster, Marie R., Kugel, Curtis H., Weeraratna, Ashani T.

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Correction: Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance by Kaur, Amanpreet, Webster, Marie R., Marchbank, Katie, Behera, Reeti, Ndoye, Abibatou, Kugel, Curtis H., Dang, Vanessa M., Appleton, Jessica, O’Connell, Michael P., Cheng, Phil, Valiga, Alexander A., Morissette, Rachel, McDonnell, Nazli B., Ferrucci, Luigi, Kossenkov, Andrew V., Meeth, Katrina, Tang, Hsin-Yao, Yin, Xiangfan, Wood, William H., Lehrmann, Elin, Becker, Kevin G., Flaherty, Keith T., Frederick, Dennie T., Wargo, Jennifer A., Cooper, Zachary A., Tetzlaff, Michael T., Hudgens, Courtney, Aird, Katherine M., Zhang, Rugang, Xu, Xiaowei, Liu, Qin, Bartlett, Edmund, Karakousis, Giorgos, Eroglu, Zeynep, Lo, Roger S., Chan, Matthew, Menzies, Alexander M., Long, Georgina V., Johnson, Douglas B., Sosman, Jeffrey, Schilling, Bastian, Schadendorf, Dirk, Speicher, David W., Bosenberg, Marcus, Ribas, Antoni, Weeraratna, Ashani T.

“…Nature 532, 250–254 (2016); doi:10.1038/nature17392 In Fig. 5a of this Letter, the labels PBS and PLX4720 were inadvertently reversed. The corrected Fig. 5a is…”
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Abstract 2158: RAF signaling and SHOC2 mediate mutant NRAS acquired resistance to RAF inhibitors in melanoma by Kugel, Curtis H.

“…RAS signaling through extracellular signal-regulated kinase 1/2 (ERK1/2)/mitogen-activated kinase (MAPK) pathway is critical for normal cellular homeostasis…”
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Abstract 105: CADM1 is a TWIST1-regulated suppressor of melanoma invasion and survival by Hartsough, Edward J., Weiss, Michele B., Heilman, Shea A., Purwin, Timothy J., Kugel, Curtis H., Rosenbaum, Sheera R., Erkes, Dan A., Tiago, Manoela, Chervoneva, Inna, Aplin, Andrew E.

“…Metastatic melanoma is the deadliest form of skin cancer; however, patients diagnosed and treated prior to metastatic dissemination have a good prognosis. The…”
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Abstract 4089: CADM1 is a TWIST1 regulated suppressor of melanoma invasion by Hartsough, Edward J., Weiss, Michele B., Kugel, Curtis H., Rosenbaum, Sheera R., Aplin, Andrew E.

“…Melanoma is the deadliest form of skin cancer; however, with early detection prior to metastatic dissemination, patients generally have a good prognosis…”
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Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations by Kugel, 3rd, Curtis H, Douglass, Stephen M, Webster, Marie R, Kaur, Amanpreet, Liu, Qin, Yin, Xiangfan, Weiss, Sarah A, Darvishian, Farbod, Al-Rohil, Rami N, Ndoye, Abibatou, Behera, Reeti, Alicea, Gretchen M, Ecker, Brett L, Fane, Mitchell, Allegrezza, Michael J, Svoronos, Nikolaos, Kumar, Vinit, Wang, Daniel Y, Somasundaram, Rajasekharan, Hu-Lieskovan, Siwen, Ozgun, Alpaslan, Herlyn, Meenhard, Conejo-Garcia, Jose R, Gabrilovich, Dmitry, Stone, Erica L, Nowicki, Theodore S, Sosman, Jeffrey, Rai, Rajat, Carlino, Matteo S, Long, Georgina V, Marais, Richard, Ribas, Antoni, Eroglu, Zeynep, Davies, Michael A, Schilling, Bastian, Schadendorf, Dirk, Xu, Wei, Amaravadi, Ravi K, Menzies, Alexander M, McQuade, Jennifer L, Johnson, Douglas B, Osman, Iman, Weeraratna, Ashani T

“…We have shown that the aged microenvironment increases melanoma metastasis, and decreases response to targeted therapy, and here we queried response to…”
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Erratum: Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance by Kaur, Amanpreet, Webster, Marie R., Marchbank, Katie, Behera, Reeti, Ndoye, Abibatou, Kugel, Curtis H., Dang, Vanessa M., Appleton, Jessica, O’Connell, Michael P., Cheng, Phil, Valiga, Alexander A., Morissette, Rachel, McDonnell, Nazli B., Ferrucci, Luigi, Kossenkov, Andrew V., Meeth, Katrina, Tang, Hsin-Yao, Yin, Xiangfan, Wood, William H., Lehrmann, Elin, Becker, Kevin G., Flaherty, Keith T., Frederick, Dennie T., Wargo, Jennifer A., Cooper, Zachary A., Tetzlaff, Michael T., Hudgens, Courtney, Aird, Katherine M., Zhang, Rugang, Xu, Xiaowei, Liu, Qin, Bartlett, Edmund, Karakousis, Giorgos, Eroglu, Zeynep, Lo, Roger S., Chan, Matthew, Menzies, Alexander M., Long, Georgina V., Johnson, Douglas B., Sosman, Jeffrey, Schilling, Bastian, Schadendorf, Dirk, Speicher, David W., Bosenberg, Marcus, Ribas, Antoni, Weeraratna, Ashani T.

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Adaptive and acquired responses of mutant braf melanomas to RAF/MEK inhibitors by Kugel, Curtis H

“…Since the discovery of BRAF mutations in over 50% of melanomas, various small molecule inhibitors against mutant BRAF have been developed for the treatment of…”
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