Search Results - "KUEHNE, Ana"

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans by Loo, Yueh-Ming, McTamney, Patrick M, Arends, Rosalinda H, Abram, Michael E, Aksyuk, Anastasia A, Diallo, Seme, Flores, Daniel J, Kelly, Elizabeth J, Ren, Kuishu, Roque, Richard, Rosenthal, Kim, Streicher, Katie, Tuffy, Kevin M, Bond, Nicholas J, Cornwell, Owen, Bouquet, Jerome, Cheng, Lily I, Dunyak, James, Huang, Yue, Rosenbaum, Anton I, Pilla Reddy, Venkatesh, Andersen, Hanne, Carnahan, Robert H, Crowe, Jr, James E, Kuehne, Ana I, Herbert, Andrew S, Dye, John M, Bright, Helen, Kallewaard, Nicole L, Pangalos, Menelas N, Esser, Mark T

“…Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, there remains a need for more prevention and treatment options…”
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Lassa virus entry requires a trigger-induced receptor switch by Jae, Lucas T., Raaben, Matthijs, Herbert, Andrew S., Kuehne, Ana I., Wirchnianski, Ariel S., Soh, Timothy K., Stubbs, Sarah H., Janssen, Hans, Damme, Markus, Saftig, Paul, Whelan, Sean P., Dye, John M., Brummelkamp, Thijn R.

“…Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever. Despite its broad tropism, chicken cells were reported 30 years ago to…”
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Ebola virus entry requires the cholesterol transporter Niemann–Pick C1 by Carette, Jan E., Raaben, Matthijs, Wong, Anthony C., Herbert, Andrew S., Obernosterer, Gregor, Mulherkar, Nirupama, Kuehne, Ana I., Kranzusch, Philip J., Griffin, April M., Ruthel, Gordon, Cin, Paola Dal, Dye, John M., Whelan, Sean P., Chandran, Kartik, Brummelkamp, Thijn R.

“…Filovirus infectivity factors The extraordinary virulence of the Ebola and Marburg filoviruses has spurred intensive research into the molecular mechanisms by…”
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Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease by Dye, John M, Herbert, Andrew S, Kuehne, Ana I, Barth, James F, Muhammad, Majidat A, Zak, Samantha E, Ortiz, Ramon A, Prugar, Laura I, Pratt, William D

“…Antibody therapies to prevent or limit filovirus infections have received modest interest in recent years, in part because of early negative experimental…”
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NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry by Raaben, Matthijs, Jae, Lucas T., Herbert, Andrew S., Kuehne, Ana I., Stubbs, Sarah H., Chou, Yi-ying, Blomen, Vincent A., Kirchhausen, Tomas, Dye, John M., Brummelkamp, Thijn R., Whelan, Sean P.

“…Arenaviruses cause fatal hemorrhagic disease in humans. Old World arenavirus glycoproteins (GPs) mainly engage α-dystroglycan as a cell-surface receptor, while…”
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Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever by Fels, J. Maximilian, Maurer, Daniel P., Herbert, Andrew S., Wirchnianski, Ariel S., Vergnolle, Olivia, Cross, Robert W., Abelson, Dafna M., Moyer, Crystal L., Mishra, Akaash K., Aguilan, Jennifer T., Kuehne, Ana I., Pauli, Noel T., Bakken, Russell R., Nyakatura, Elisabeth K., Hellert, Jan, Quevedo, Gregory, Lobel, Leslie, Balinandi, Stephen, Lutwama, Julius J., Zeitlin, Larry, Geisbert, Thomas W., Rey, Felix A., Sidoli, Simone, McLellan, Jason S., Lai, Jonathan R., Bornholdt, Zachary A., Dye, John M., Walker, Laura M., Chandran, Kartik

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for…”
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Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design by Khurana, Surender, Grubbs, Gabrielle, Ravichandran, Supriya, Cluff, Emily, Kim, JungHyun, Kuehne, Ana I., Zak, Samantha, Dye, John M., Lutwama, Julius J., Herbert, Andrew S.

“…Limited knowledge exists on the quality of polyclonal antibody responses generated following Marburg virus (MARV) infection and its evolution in survivors. In…”
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A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses by Wec, Anna Z., Nyakatura, Elisabeth K., Herbert, Andrew S., Howell, Katie A., Holtsberg, Frederick W., Bakken, Russell R., Mittler, Eva, Christin, John R., Shulenin, Sergey, Jangra, Rohit K., Bharrhan, Sushma, Kuehne, Ana I., Bornholdt, Zachary A., Flyak, Andrew I., Saphire, Erica Ollmann, Crowe, James E., Aman, M. Javad, Dye, John M., Lai, Jonathan R., Chandran, Kartik

“…There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect against Ebola virus and other filoviruses. The conserved, essential…”
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Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies by Wirchnianski, Ariel S, Nyakatura, Elisabeth K, Herbert, Andrew S, Kuehne, Ana I, Abbasi, Shawn A, Florez, Catalina, Storm, Nadia, McKay, Lindsay G A, Dailey, Leandrew, Kuang, Erin, Abelson, Dafna M, Wec, Anna Z, Chakraborti, Srinjoy, Holtsberg, Frederick W, Shulenin, Sergey, Bornholdt, Zachary A, Aman, M Javad, Honko, Anna N, Griffiths, Anthony, Dye, John M, Chandran, Kartik, Lai, Jonathan R

“…Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as…”
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Ebola virus entry requires the host-programmed recognition of an intracellular receptor by Miller, Emily Happy, Obernosterer, Gregor, Raaben, Matthijs, Herbert, Andrew S, Deffieu, Maika S, Krishnan, Anuja, Ndungo, Esther, Sandesara, Rohini G, Carette, Jan E, Kuehne, Ana I, Ruthel, Gordon, Pfeffer, Suzanne R, Dye, John M, Whelan, Sean P, Brummelkamp, Thijn R, Chandran, Kartik

“…Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite considerable efforts, no essential cellular receptors for filovirus entry…”
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Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail by Kugelman, Jeffrey R., Kugelman-Tonos, Johanny, Ladner, Jason T., Pettit, James, Keeton, Carolyn M., Nagle, Elyse R., Garcia, Karla Y., Froude, Jeffrey W., Kuehne, Ana I., Kuhn, Jens H., Bavari, Sina, Zeitlin, Larry, Dye, John M., Olinger, Gene G., Sanchez-Lockhart, Mariano, Palacios, Gustavo F.

“…MB-003, a plant-derived monoclonal antibody cocktail used effectively in treatment of Ebola virus infection in non-human primates, was unable to protect two of…”
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Long-term Sudan Virus Ebola Survivors Maintain Multiple Antiviral Defense Mechanisms by Sobarzo, Ariel, Moné, Yves, Lang, Steven, Gelkop, Sigal, Brangel, Polina, Kuehne, Ana I, McKendry, Rachel A, Mell, Joshua Chang, Ahmed, Azad, Davis, Claytus, Dye, John M, Lutwama, Julius Julian, Lobel, Leslie, Veas, Francisco, Ehrlich, Garth D

“…Abstract Background The critical issues of sustained memory immunity following ebolavirus disease among long-term survivors are still unclear. Methods Here, we…”
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A Longitudinal Analysis of Memory Immune Responses in Convalescent Crimean-Congo Hemorrhagic Fever Survivors in Uganda by Cohen, Courtney A, Balinandi, Stephen, Kuehne, Ana I, Rock, Michelle L, Bonagofski, Luke G, Ricks, Keersten M, Davis, Ian, Abelson, Dafna, Stonier, Spencer W, Odongo, Matthew, Bornholdt, Zachary A, Zeitlin, Larry, Moyer, Crystal, Cose, Stephen, Dye, John M, Lutwama, Julius J, Herbert, Andrew S

“…Evaluating the adaptive immune responses to natural infection with Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV) in human survivors is critical to the…”
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Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection by Slough, Megan M., Li, Rong, Herbert, Andrew S., Lasso, Gorka, Kuehne, Ana I., Monticelli, Stephanie R., Bakken, Russell R., Liu, Yanan, Ghosh, Agnidipta, Moreau, Alicia M., Zeng, Xiankun, Rey, Félix A., Guardado-Calvo, Pablo, Almo, Steven C., Dye, John M., Jangra, Rohit K., Wang, Zhongde, Chandran, Kartik

“…Andes virus (ANDV) and Sin Nombre virus (SNV) are the etiologic agents of severe hantavirus cardiopulmonary syndrome (HCPS) in the Americas for which no…”
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Author Correction: Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection by Slough, Megan M., Li, Rong, Herbert, Andrew S., Lasso, Gorka, Kuehne, Ana I., Monticelli, Stephanie R., Bakken, Russell R., Liu, Yanan, Ghosh, Agnidipta, Moreau, Alicia M., Zeng, Xiankun, Rey, Félix A., Guardado-Calvo, Pablo, Almo, Steven C., Dye, John M., Jangra, Rohit K., Wang, Zhongde, Chandran, Kartik

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Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability by Zhao, Xuelian, Howell, Katie A., He, Shihua, Brannan, Jennifer M., Wec, Anna Z., Davidson, Edgar, Turner, Hannah L., Chiang, Chi-I., Lei, Lin, Fels, J. Maximilian, Vu, Hong, Shulenin, Sergey, Turonis, Ashley N., Kuehne, Ana I., Liu, Guodong, Ta, Mi, Wang, Yimeng, Sundling, Christopher, Xiao, Yongli, Spence, Jennifer S., Doranz, Benjamin J., Holtsberg, Frederick W., Ward, Andrew B., Chandran, Kartik, Dye, John M., Qiu, Xiangguo, Li, Yuxing, Aman, M. Javad

“…While neutralizing antibodies are highly effective against ebolavirus infections, current experimental ebolavirus vaccines primarily elicit species-specific…”
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Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Protects Nonhuman Primates from Intramuscular and Aerosol Challenge with Ebolavirus by Herbert, Andrew S, Kuehne, Ana I, Barth, James F, Ortiz, Ramon A, Nichols, Donald K, Zak, Samantha E, Stonier, Spencer W, Muhammad, Majidat A, Bakken, Russell R, Prugar, Laura I, Olinger, Gene G, Groebner, Jennifer L, Lee, John S, Pratt, William D, Custer, Max, Kamrud, Kurt I, Smith, Jonathan F, Hart, Mary Kate, Dye, John M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A shared structural solution for neutralizing ebolaviruses by Dias, João M, Kuehne, Ana I, Abelson, Dafna M, Bale, Shridhar, Wong, Anthony C, Halfmann, Peter, Muhammad, Majidat A, Fusco, Marnie L, Zak, Samantha E, Kang, Eugene, Kawaoka, Yoshihiro, Chandran, Kartik, Dye, John M, Saphire, Erica Ollmann

“…The surface glycoprotein of the distinct ebolavirus responsible for the largest outbreak yet described (Sudan Gulu) has been crystallized in complex with a…”
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Monoclonal antibody therapy for Junin virus infection by Zeitlin, Larry, Geisbert, Joan B., Deer, Daniel J., Fenton, Karla A., Bohorov, Ognian, Bohorova, Natasha, Goodman, Charles, Kim, Do, Hiatt, Andrew, Pauly, Michael H., Velasco, Jesus, Whaley, Kevin J., Altmann, Friedrich, Gruber, Clemens, Steinkellner, Herta, Honko, Anna N., Kuehne, Ana I., Aman, M. Javad, Sahandi, Sara, Enterlein, Sven, Zhan, Xiaoguo, Enria, Delia, Geisbert, Thomas W.

“…Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the…”
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Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses by Natesan, Mohan, Jensen, Stig M, Keasey, Sarah L, Kamata, Teddy, Kuehne, Ana I, Stonier, Spencer W, Lutwama, Julius Julian, Lobel, Leslie, Dye, John M, Ulrich, Robert G

“…A detailed understanding of serological immune responses to Ebola and Marburg virus infections will facilitate the development of effective diagnostic methods,…”
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