Search Results - "KUCK, Dirk"

Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells by Kuck, Dirk, Caulfield, Thomas, Lyko, Frank, Medina-Franco, Jose L

“…Enzymes involved in the epigenetic regulation of the genome represent promising starting points for therapeutic intervention by small molecules, and DNA…”
Get full text

Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach by Medina-Franco, Jose L., López-Vallejo, Fabian, Kuck, Dirk, Lyko, Frank

“…DNA methyltransferases (DNMTs) represent promising targets for the development of unique anticancer drugs. However, all DNMT inhibitors currently in clinical…”
Get full text

Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin by Falckenhayn, Cassandra, Bienkowska, Agata, Söhle, Jörn, Wegner, Katrin, Raddatz, Guenter, Kristof, Boris, Kuck, Dirk, Siegner, Ralf, Kaufmann, Ronny, Korn, Julia, Baumann, Sascha, Lange, Daniela, Schepky, Andreas, Völzke, Henry, Kaderali, Lars, Winnefeld, Marc, Lyko, Frank, Grönniger, Elke

“…Changes in DNA methylation patterning have been reported to be a key hallmark of aged human skin. The altered DNA methylation patterns are correlated with…”
Get full text

Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation by Hagemann, Sabine, Kuck, Dirk, Stresemann, Carlo, Prinz, Florian, Brueckner, Bodo, Mund, Cora, Mumberg, Dominik, Sommer, Anette

“…Silencing of genes by hypermethylation contributes to cancer progression and has been shown to occur with increased frequency at specific genomic loci…”
Get full text

Vacuolating Cytotoxin of Helicobacter pylori Induces Apoptosis in the Human Gastric Epithelial Cell Line AGS by KUCK, Dirk, KOLMERER, Bernhard, IKING-KONERT, Christof, KRAMMER, Peter H, STREMMEL, Wolfgang, RUDI, Jochen

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Intranasal Vaccination with Recombinant Adeno-Associated Virus Type 5 against Human Papillomavirus Type 16 L1 by KUCK, Dirk, LAU, Tobias, LEUCHS, Barbara, KERN, Andrea, MULLER, Martin, GISSMANN, Lutz, KLEINSCHMIDT, Jürgen A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation by Kuck, Dirk, Singh, Narender, Lyko, Frank, Medina-Franco, Jose L.

“…The first small molecules reported with biochemical selectivity towards an individual DNMT enzyme were discovered by virtual screening and experimental…”
Get full text

Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors by Castellano, Sabrina, Kuck, Dirk, Viviano, Monica, Yoo, Jakyung, López-Vallejo, Fabian, Conti, Paola, Tamborini, Lucia, Pinto, Andrea, Medina-Franco, José L, Sbardella, Gianluca

“…A series of Δ(2)-isoxazoline constrained analogues of procaine/procainamide (7a-k and 8a-k) were prepared and their inhibitory activity against DNA…”
Get full text

DNA methyltransferase inhibitors for cancer therapy by Brueckner, Bodo, Kuck, Dirk, Lyko, Frank

“…Aberrant DNA methylation patterns, including hypermethylation of tumor suppressor genes, have been described in many human cancers. These epigenetic mutations…”
Get full text

Constrained Analogues of Procaine as Novel Small Molecule Inhibitors of DNA Methyltransferase-1 by Castellano, Sabrina, Kuck, Dirk, Sala, Marina, Novellino, Ettore, Lyko, Frank, Sbardella, Gianluca

“…Constrained analogues of procaine were synthesized, and their inhibiting activity against DNMT1 was tested. Among them, the most potent compound, derivative…”
Get full text

Synthesis and Biochemical Evaluation of Δ2-Isoxazoline Derivatives as DNA Methyltransferase 1 Inhibitors by Castellano, Sabrina, Kuck, Dirk, Viviano, Monica, Yoo, Jakyung, López-Vallejo, Fabian, Conti, Paola, Tamborini, Lucia, Pinto, Andrea, Medina-Franco, José L, Sbardella, Gianluca

“…A series of Δ2-isoxazoline constrained analogues of procaine/procainamide (7a–k and 8a–k) were prepared and their inhibitory activity against DNA…”
Get full text

Abstract 1036: Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation by Stresemann, Carlo, Hagemann, Sabine, Mund, Cora, Kuck, Dirk, Prinz, Florian, Brueckner, Bodo, Mumberg, Dominik, Lyko, Frank, Sommer, Anette

“…Abstract Silencing of genes by DNA hypermethylation contributes to cancer progression and has been shown to occur with increased frequency at specific genomic…”
Get full text

Substituted purine and 7-deazapurine compounds as modulators of epigenetic enzymes: a patent evaluation (WO2012075381) by Lipka, Daniel B, Kuck, Dirk, Kliem, Christian, Gerhauser, Clarissa

“…The patent presents 140 purine and 7-azapurine derivatives as potent inhibitors of DOT1L histone methyltransferase that might be useful in the treatment of…”
Get more information

Synthesis and Biochemical Evaluation of Δ 2 -Isoxazoline Derivatives as DNA Methyltransferase 1 Inhibitors by Castellano, Sabrina, Kuck, Dirk, Viviano, Monica, Yoo, Jakyung, López-Vallejo, Fabian, Conti, Paola, Tamborini, Lucia, Pinto, Andrea, Medina-Franco, José L., Sbardella, Gianluca

Get full text

Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis by Rudi, J, Kuck, D, Strand, S, von Herbay, A, Mariani, S M, Krammer, P H, Galle, P R, Stremmel, W

“…Helicobacter pylori infection is associated with chronic gastritis, peptic ulceration, and gastric carcinoma. The potential role of CD95-mediated apoptosis was…”
Get full text

Diversity of Helicobacter pylori VacA and CagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases by RUDI, J, KOLB, C, MAIWALD, M, KUCK, D, SIEG, A, GALLE, P. R, STREMMEL, W

“…The vacuolating cytotoxin and the cytotoxin-associated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter…”
Get full text

Development of AAV serotype-specific ELISAs using novel monoclonal antibodies by Kuck, Dirk, Kern, Andrea, Kleinschmidt, Jürgen A.

“…Adeno-associated viruses (AAV) have been developed and evaluated as recombinant vectors for gene therapy. More recently, due to the advantages they offer for…”
Get full text

Efficiency of HPV 16 L1/E7 DNA immunization: Influence of cellular localization and capsid assembly by Kuck, Dirk, Leder, Christoph, Kern, Andrea, Müller, Martin, Piuko, Konrad, Gissmann, Lutz, Kleinschmidt, Jürgen A.

“…Infections by human papillomaviruses (HPV) are the major cause of uterine cancer in women worldwide. Aiming to develop a combined prophylactic and therapeutic…”
Get full text

Direct determination of Helicobacter pylori vacA genotypes and cagA gene in gastric biopsies and relationship to gastrointestinal diseases by RUDI, J, RUDY, A, MAIWALD, M, KUCK, D, SIEG, A, STREMMEL, W

“…Our aim was to detect Helicobacter pylori (H. pylori) from gastric biopsies of 248 patients using a novel, polymerase chain reaction (PCR)-based methodology,…”
Get full text

Direct Determination ofHelicobacter Pylori VacaGenotypes andCagaGene in Gastric Biopsies and Relationship To Gastrointestinal Diseases by Rudi, Jochen, Rudy, Andreas, Maiwald, Matthias, Kuck, Dirk, Sieg, Andreas, Stremmel, Wolfgang

“…Our aim was to detect Helicobacter pylori (H. pylori) from gastric biopsies of 248 patients using a novel, polymerase chain reaction (PCR)-based methodology,…”
Get full text