Search Results - "KUBOTA, Naoto"

Role of Insulin Resistance in MAFLD by Sakurai, Yoshitaka, Kubota, Naoto, Yamauchi, Toshimasa, Kadowaki, Takashi

“…Many studies have reported that metabolic dysfunction is closely involved in the complex mechanism underlying the development of non-alcoholic fatty liver…”
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Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway by Kubota, Tetsuya, Kubota, Naoto, Kadowaki, Takashi

“…Since the discovery of the tyrosine kinase activity of the insulin receptor (IR), researchers have been engaged in intensive efforts to resolve physiological…”
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Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification by Kurebayashi, Yutaka, Ojima, Hidenori, Tsujikawa, Hanako, Kubota, Naoto, Maehara, Junki, Abe, Yuta, Kitago, Minoru, Shinoda, Masahiro, Kitagawa, Yuko, Sakamoto, Michiie

“…Immune cells constitute an important element of tumor tissue. Accumulating evidence indicates their clinicopathological significance in predicting prognosis…”
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Mapping of promoter usage QTL using RNA-seq data reveals their contributions to complex traits by Kubota, Naoto, Suyama, Mikita

“…Genomic variations are associated with gene expression levels, which are called expression quantitative trait loci (eQTL). Most eQTL may affect the total gene…”
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Molecular and immune landscape of hepatocellular carcinoma to guide therapeutic decision-making by Dhanasekaran, Renumathy, Suzuki, Hiroyuki, Lemaitre, Lea, Kubota, Naoto, Hoshida, Yujin

“…Liver cancer, primarily HCC, exhibits highly heterogeneous histological and molecular aberrations across tumors and within individual tumor nodules. Such…”
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Immune microenvironment of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and liver metastasis of colorectal adenocarcinoma: Relationship with histopathological and molecular classifications by Kurebayashi, Yutaka, Kubota, Naoto, Sakamoto, Michiie

“…Tumor tissue is composed of tumor cells and tumor stroma. Tumor stroma contains various immune cells and non‐immune stromal cells, forming a complex tumor…”
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Cooperation between artificial intelligence and endoscopists for diagnosing invasion depth of early gastric cancer by Goto, Atsushi, Kubota, Naoto, Nishikawa, Jun, Ogawa, Ryo, Hamabe, Koichi, Hashimoto, Shinichi, Ogihara, Hiroyuki, Hamamoto, Yoshihiko, Yanai, Hideo, Miura, Osamu, Takami, Taro

“…Background and study aims The diagnostic ability of endoscopists to determine invasion depth of early gastric cancer is not favorable. We designed an…”
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The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis by Kobayashi, Masatoshi, Ohsugi, Mitsuru, Sasako, Takayoshi, Awazawa, Motoharu, Umehara, Toshihiro, Iwane, Aya, Kobayashi, Naoki, Okazaki, Yukiko, Kubota, Naoto, Suzuki, Ryo, Waki, Hironori, Horiuchi, Keiko, Hamakubo, Takao, Kodama, Tatsuhiko, Aoe, Seiichiro, Tobe, Kazuyuki, Kadowaki, Takashi, Ueki, Kohjiro

“…Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be…”
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Physiological and pathophysiological actions of insulin in the liver by Kubota, Naoto, Kubota, Tetsuya, Kadowaki, Takashi

“…The liver plays an important role in the control of glucose homeostasis. When insulin levels are low, such as in the fasting state, gluconeogenesis and…”
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STIE: Single-cell level deconvolution, convolution, and clustering in in situ capturing-based spatial transcriptomics by Zhu, Shijia, Kubota, Naoto, Wang, Shidan, Wang, Tao, Xiao, Guanghua, Hoshida, Yujin

“…In in situ capturing-based spatial transcriptomics, spots of the same size and printed at fixed locations cannot precisely capture the randomly-located single…”
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Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism by Sasako, Takayoshi, Ohsugi, Mitsuru, Kubota, Naoto, Itoh, Shinsuke, Okazaki, Yukiko, Terai, Ai, Kubota, Tetsuya, Yamashita, Satoshi, Nakatsukasa, Kunio, Kamura, Takumi, Iwayama, Kaito, Tokuyama, Kumpei, Kiyonari, Hiroshi, Furuta, Yasuhide, Shibahara, Junji, Fukayama, Masashi, Enooku, Kenichiro, Okushin, Kazuya, Tsutsumi, Takeya, Tateishi, Ryosuke, Tobe, Kazuyuki, Asahara, Hiroshi, Koike, Kazuhiko, Kadowaki, Takashi, Ueki, Kohjiro

“…Dynamic metabolic changes occur in the liver during the transition between fasting and feeding. Here we show that transient ER stress responses in the liver…”
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Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease by Ochiai, Toshitaka, Sano, Toshiharu, Nagayama, Takeru, Kubota, Naoto, Kadowaki, Takashi, Wakabayashi, Tomoko, Iwatsubo, Takeshi

“…Insulin signaling has been implicated in the metabolism as well as aging and longevity. Type 2 diabetes mellitus and its core pathology, insulin resistance,…”
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Innate Lymphoid Cells in the Induction of Obesity by Sasaki, Takaharu, Moro, Kazuyo, Kubota, Tetsuya, Kubota, Naoto, Kato, Tamotsu, Ohno, Hiroshi, Nakae, Susumu, Saito, Hirohisa, Koyasu, Shigeo

“…Complex interactions between immune cells are an important component in the induction of obesity. Here, we show that Il2rg−/−Rag2−/− mice lacking all…”
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The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS by Kadowaki, Takashi, Yamauchi, Toshimasa, Kubota, Naoto

“…Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing activity. A decrease in the circulating levels of…”
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Tofogliflozin Improves Insulin Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice by Obata, Atsushi, Kubota, Naoto, Kubota, Tetsuya, Iwamoto, Masahiko, Sato, Hiroyuki, Sakurai, Yoshitaka, Takamoto, Iseki, Katsuyama, Hisayuki, Suzuki, Yoshiyuki, Fukazawa, Masanori, Ikeda, Sachiya, Iwayama, Kaito, Tokuyama, Kumpei, Ueki, Kohjiro, Kadowaki, Takashi

“…Sodium glucose cotransporter 2 inhibitors have attracted attention as they exert antidiabetic and antiobesity effects. In this study, we investigated the…”
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An integrated analysis of public genomic data unveils a possible functional mechanism of psoriasis risk via a long-range ERRFI1 enhancer by Kubota, Naoto, Suyama, Mikita

“…Psoriasis is a chronic inflammatory skin disease, for which genome-wide association studies (GWAS) have identified many genetic variants as risk markers…”
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Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity by Kubota, Tetsuya, Inoue, Mariko, Kubota, Naoto, Takamoto, Iseki, Mineyama, Tomoka, Iwayama, Kaito, Tokuyama, Kumpei, Moroi, Masao, Ueki, Kohjiro, Yamauchi, Toshimasa, Kadowaki, Takashi

“…M2a-subtype macrophage activation is known to be impaired in obesity, although the underlying mechanisms remain poorly understood. Herein, we demonstrate that,…”
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Diurnal changes in bacterial settlement on the Peyer’s patch and surrounding mucosa in the rat ileum and its effect against the intestinal immune system by Mantani, Youhei, Sakata, Nanami, Kubota, Naoto, Shimada, Asaka, Nakanishi, Satoki, Yokoyama, Toshifumi, Hoshi, Nobuhiko

“…Our previous study revealed the diurnal change in the indigenous bacteria settling on the terminal region of the rat ileum. In the present study, we…”
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Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding by Suyama, Shigetomo, Maekawa, Fumihiko, Maejima, Yuko, Kubota, Naoto, Kadowaki, Takashi, Yada, Toshihiko

“…Adiponectin regulates glucose and lipid metabolism, acting against metabolic syndrome and atherosclerosis. Accumulating evidence suggest that adiponectin acts…”
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The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells by Kobayashi, Norio, Okae, Hiroaki, Hiura, Hitoshi, Kubota, Naoto, Kobayashi, Eri H., Shibata, Shun, Oike, Akira, Hori, Takeshi, Kikutake, Chie, Hamada, Hirotaka, Kaji, Hirokazu, Suyama, Mikita, Bortolin-Cavaillé, Marie-Line, Cavaillé, Jérôme, Arima, Takahiro

“…The first cell fate commitment during mammalian development is the specification of the inner cell mass and trophectoderm. This irreversible cell fate…”
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