Search Results - "KUBO, Kinya"

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans by Kazuki, Yasuhiro, Kobayashi, Kaoru, Aueviriyavit, Sasitorn, Oshima, Takeshi, Kuroiwa, Yoshimi, Tsukazaki, Yasuko, Senda, Naoto, Kawakami, Hiroki, Ohtsuki, Sumio, Abe, Satoshi, Takiguchi, Masato, Hoshiya, Hidetoshi, Kajitani, Naoyo, Takehara, Shoko, Kubo, Kinya, Terasaki, Tetsuya, Chiba, Kan, Tomizuka, Kazuma, Oshimura, Mitsuo

“…Human CYP3A is the most abundant P450 isozyme present in the human liver and small intestine, and metabolizes around 50% of medical drugs on the market. The…”
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KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties by NAKAMURA, Kazuhide, TAGUCHI, Eri, SUZUKI, Rika, KUBO, Kinya, SHIBUYA, Masabumi, ISOE, Toshiyuki, MIURA, Toru, YAMAMOTO, Atsushi, TAKAHASHI, Kazumi, BICHAT, Francis, GUILBAUD, Nicolas, HASEGAWA, Kazumasa, KUBO, Kazuo, FUJIWARA, Yasunari

“…Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis by stimulating the proangiogenic signaling of endothelial cells via activation…”
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Development of a High-Sensitivity Quantitation Method for Arginine Vasopressin by High-Performance Liquid Chromatography Tandem Mass Spectrometry, and Comparison with Quantitative Values by Radioimmunoassay by TSUKAZAKI, Yasuko, SENDA, Naoto, KUBO, Kinya, YAMADA, Shigeru, KUGOH, Hiroyuki, KAZUKI, Yasuhiro, OSHIMURA, Mitsuo

“…Human plasma arginine vasopressin (AVP) levels serve as a clinically relevant marker of diabetes and related syndromes. We developed a highly sensitive method…”
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Anti-infectious Activity of Tryptophan Metabolites in the L-Tryptophan–L-Kynurenine Pathway by Narui, Koji, Noguchi, Norihisa, Saito, Aya, Kakimi, Kazuhiro, Motomura, Noboru, Kubo, Kinya, Takamoto, Shinichi, Sasatsu, Masanori

“…To study the anti-infectious effect of a vascular allograft, the antimicrobial activity of tryptophan metabolites mediated by indoleamine 2,3-dioxygenase was…”
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Complement Activation Plays a Key Role in Antibody-Induced Infusion Toxicity in Monkeys and Rats by Tawara, Tomonori, Hasegawa, Kazumasa, Sugiura, Yusuke, Harada, Katsuhiko, Miura, Toru, Hayashi, Sunao, Tahara, Tomoyuki, Ishikawa, Masaharu, Yoshida, Hideaki, Kubo, Kinya, Ishida, Isao, Kataoka, Shiro

“…Infusion reactions are a major side effect of the administration of therapeutic Abs and are the result of a complex immune reaction. In this study, we report…”
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Effects of Mandibular Deviation on Brain Activation During Clenching: An fMRI Preliminary Study by Otsuka, Takero, Watanabe, Kazuko, Hirano, Yoshiyuki, Kubo, Kinya, Miyake, Shinjiro, Sato, Sadao, Sasaguri, Kenichi

“…Using functional magnetic resonance imaging (fMRI) in eight healthy human subjects, the present study measured blood oxygenation level-dependent (BOLD) signals…”
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Application of the Improved BALB/c 3T3 Cell Transformation Assay to the Examination of the Initiating and Promoting Activities of Chemicals: The Second Inter-laboratory Collaborative Study by the Non-genotoxic Carcinogen Study Group of Japan by Tsuchiya, Toshiyuki, Umeda, Makoto, Tanaka, Noriho, Sakai, Ayako, Nishiyama, Hiroshi, Yoshimura, Isao, Ajimi, Syozo, Asada, Shin, Asakura, Masumi, Baba, Hiroshi, Dewa, Yasuaki, Ebe, Youji, Fushiwaki, Yuichi, Hagiwara, Yuji, Hamada, Shuichi, Hamamura, Tetsuo, Iwase, Yumiko, Kajiwara, Yoshitsugu, Kasahara, Yasushi, Kato, Yukihiko, Kawabata, Masayoshi, Kitada, Emiko, Kaneko, Kazuko, Kizaki, Yuko, Kubo, Kinya, Miura, Daisaku, Mashiko, Kaori, Mizuhashi, Fukutaro, Muramatsu, Dai, Nakajima, Madoka, Nakamura, Tetsu, Oishi, Hidetoshi, Sasaki, Toshiaki, Shimada, Sawako, Takahashi, Chitose, Takeda, Yuko, Wakuri, Sinobu, Yajima, Nobuhiro, Yajima, Satoshi, Yatsushiro, Tomoko

“…The Non-genotoxic Carcinogen Study Group in the Environmental Mutagen Society of Japan organised the second step of the inter-laboratory collaborative study on…”
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interlaboratory validation study of the improved transformation assay employing Balb/c 3T3 cells: results of a collaborative study on the two-stage cell transformation assay by the non-genotoxic carcinogen study group by Tsuchiya, T, Umeda, M, Nishiyama, H, Yoshimura, I, Ajimi, S, Asakura, M, Baba, H, Dewa, Y, Ebe, Y, Fushiwaki, Y

“…The Non-genotoxic Carcinogen Study Group of the Environmental Mutagen Society of Japan organised the first step of an interlaboratory validation study on an…”
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Maternal chewing rescues stress-induced deterioration of learning-stimulated hippocampal neurogenesis in her beby by Kubo, Kinya, Karasawa, Nobuyuki, Onozuka, Minoru

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Effects of occlusal disharmony on the cholinergic system in the septohippocampal tract of SAMP8 mice by Katayama, Tasuku, Mori, Daisuke, Miyake, Hidekazu, Fujiwara, Shuu, Karasawa, Nobuyuki, Onozuka, Minoru, Kubo, Kinya

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Effects of occlusal disharmony during pregnancy on maze performance and hippocampal dentate gyrus cell proliferation in adult progeny by Ichihashi, Yukiko, Kurata, Chika, Iinuma, Mitsuo, Tamura, Yasuo, Onozuka, Minoru, Kubo, Kinya

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Taste preferences and activation in the association cortex in humans by Mizuno, Junzo, Yuyama, Noriyuki, Kubo, Kinya, Niwa, Masami, Watanabe, Kazuko, Onozuka, Minoru

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SFTG international collaborative study on in vitro micronucleus test IV. Using CHL cells by Wakata, Akihiro, Matsuoka, Atsuko, Yamakage, Kohji, Yoshida, Junichi, Kubo, Kinya, Kobayashi, Kazuo, Senjyu, Nami, Itoh, Satoru, Miyajima, Hirofumi, Hamada, Shuichi, Nishida, Souji, Araki, Harumi, Yamamura, Eiji, Matsui, Akiko, Thybaud, Veronique, Lorenzon, Giocondo, Marzin, Daniel, Lorge, Elisabeth

“…In this report, are presented the results of an international collaborative study on the in vitro micronucleus assay, using CHL cells. Fourteen laboratories…”
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Application of the Improved BALB/c 3T3 Cell Transformation Assay to the Examination of the Initiating and Promoting Activities of Chemicals: The Second Interlaboratory Collaborative Study by the Non-genotoxic Carcinogen Study Group of Japan by Tsuchiya, Toshiyuki, Umeda, Makoto, Tanaka, Noriho, Sakai, Ayako, Nishiyama, Hiroshi, Yoshimura, Isao, Ajimi, Syozo, Asada, Shin, Asakura, Masumi, Baba, Hiroshi, Dewa, Yasuaki, Ebe, Youji, Fushiwaki, Yuichi, Hagiwara, Yuji, Hamada, Shuichi, Hamamura, Tetsuo

“…The Non-genotoxic Carcinogen Study Group in the Environmental Mutagen Society of Japan organised the second step of the inter-laboratory collaborative study on…”
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Metabolism of eicosapentaenoic acid in the liver of rats: participation of the peroxisomal β-oxidation system in chain-shortening by KUBO, K, WATANABE, T, SUGA, T

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Orally active anti-proliferation agents : Novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors by SHIMIZU, Toshiyuki, FUJIWARA, Yasunari, IWAI, Akemi, FUKUSHIMA, Kayoko, YOSHINO, Tetsuya, MIWA, Atsushi, OSAWA, Tatsushi, SAKAI, Teruyuki, KUBO, Kinya, KUBO, Kazuo, NISHITOBA, Tsuyoshi, KIMURA, Kaname, SENGA, Terufumi, MUROOKA, Hideko

“…(6,7-Disubstituted-quinolin-4-yloxy-phenyl)(4-substituted-phenyl)amine derivatives were synthesized and evaluated by a cellular autophosphorylation assay for…”
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SFTG international collaborative study on in vitro micronucleus test by Wakata, Akihiro, Matsuoka, Atsuko, Yamakage, Kohji, Yoshida, Junichi, Kubo, Kinya, Kobayashi, Kazuo, Senjyu, Nami, Itoh, Satoru, Miyajima, Hirofumi, Hamada, Shuichi, Nishida, Souji, Araki, Harumi, Yamamura, Eiji, Matsui, Akiko, Thybaud, Veronique, Lorenzon, Giocondo, Marzin, Daniel, Lorge, Elisabeth

“…In this report, are presented the results of an international collaborative study on the in vitro micronucleus assay, using CHL cells. Fourteen laboratories…”
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Ki23819 (KRN383•HCl) Inhibits Kinase Activity of Wild Type and Mutant FLT3 Receptor Tyrosine Kinase In Vitro by Komeno, Yukiko, Kurokawa, Mineo, Imai, Yoichi, Takeshita, Masataka, Matsumura, Tomoko, Kubo, Kazuo, Yoshino, Tetsuya, Nishiyama, Uichi, Kuwaki, Tomoaki, Kubo, Kinya, Osawa, Tatsushi, Ogawa, Seishi, Chiba, Shigeru, Miwa, Atsushi, Hirai, Hisamaru

“…[Background] FLT3 is a class III receptor tyrosine kinase which is widely expressed on hematopoietic stem/progenitor cells. Two types of constitutively active…”
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SFTG international collaborative study on in vitro micronucleus test IV. Using CHL cells: SFTG international collaborative study on in vitro micronucleus test by WAKATA, Akihiro, MATSUOKA, Atsuko, NISHIDA, Souji, ARAKI, Harumi, YAMAMURA, Eiji, MATSUI, Akiko, THYBAUD, Veronique, LORENZON, Giocondo, MARZIN, Daniel, LORGE, Elisabeth, YAMAKAGE, Kohji, YOSHIDA, Junichi, KUBO, Kinya, KOBAYASHI, Kazuo, SENJYU, Nami, ITOH, Satoru, MIYAJIMA, Hirofumi, HAMADA, Shuichi

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Metaboism of Eicosapentaenoic Acid in the Liver of Rats by KUBO, KINYA, WATANABE, TAKAFUMI, SUGA, TETSUYA

“…Many studies on eicosapentaenoic acid (EPA) have confirmed its metabolic transformation to prostaglandins (PGs). However, it is not yet clear whether or not a…”
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