Search Results - "KRYSTAL, Gerald"

Development of a novel human triculture model of non-alcoholic fatty liver disease and identification of berberine as ameliorating steatosis, oxidative stress and fibrosis by Rafiei, Hossein, Yeung, Michelle, Kowalski, Sara, Krystal, Gerald, Elisia, Ingrid

“…Objectives: Non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) and hepatocarcinoma is a serious and growing…”
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Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators by Elisia, Ingrid, Pae, Han Bee, Lam, Vivian, Cederberg, Rachel, Hofs, Elyse, Krystal, Gerald

“…The RAW264.7 mouse macrophage cell line is used extensively to carry out in vitro screens for immunomodulators. Compounds that are effective at reducing the…”
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Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk by Elisia, Ingrid, Lam, Vivian, Cho, Brandon, Hay, Mariah, Li, Michael Yu, Kapeluto, Jordanna, Elliott, Tom, Harris, David, Bu, Luke, Jia, William, Leung, Hilary, Mohn, William, Krystal, Gerald

“…Obesity has reached epidemic proportions and is often accompanied by elevated levels of pro-inflammatory cytokines that promote many chronic diseases,…”
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The Pros and Cons of Low Carbohydrate and Ketogenic Diets in the Prevention and Treatment of Cancer by Elisia, Ingrid, Krystal, Gerald

“…Ketogenic diets are low carbohydrate (CHO), high fat diets that are currently very popular for weight loss. Since cancer cells typically consume far more…”
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A ketogenic diet rich in fish oil is superior to other fats in preventing NNK-induced lung cancer in A/J mice by Elisia, Ingrid, Yeung, Michelle, Kowalski, Sara, Shyp, Taras, Tee, Jason, Hollman, Serena, Wong, Amy, King, Janette, Dyer, Roger, Sorensen, Poul H., Krystal, Gerald

“…Given that ketogenic diets (KDs) are extremely high in dietary fat, we compared different fats in KDs to determine which was the best for cancer prevention…”
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Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial by Buga, Alex, Harper, David G, Sapper, Teryn N, Hyde, Parker N, Fell, Brandon, Dickerson, Ryan, Stoner, Justen T, Kackley, Madison L, Crabtree, Christopher D, Decker, Drew D, Robinson, Bradley T, Krystal, Gerald, Binzel, Katherine, Lustberg, Maryam B, Volek, Jeff S

“…Ketogenic diets may positively influence cancer through pleiotropic mechanisms, but only a few small and short-term studies have addressed feasibility and…”
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Effect of age on chronic inflammation and responsiveness to bacterial and viral challenges by Elisia, Ingrid, Lam, Vivian, Hofs, Elyse, Li, Michael Yu, Hay, Mariah, Cho, Brandon, Brooks-Wilson, Angela, Rosin, Miriam, Bu, Luke, Jia, William, Krystal, Gerald

“…To identify reliable biomarkers of age-related changes in chronic inflammation and responsiveness to bacterial and viral challenges, we evaluated endogenous…”
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Multiple pathways involved in the biosynthesis of anandamide by Liu, Jie, Wang, Lei, Harvey-White, Judith, Huang, Bill X., Kim, Hee-Yong, Luquet, Serge, Palmiter, Richard D., Krystal, Gerald, Rai, Ravi, Mahadevan, Anu, Razdan, Raj K., Kunos, George

“…Endocannabinoids, including anandamide (arachidonoyl ethanolamide) have been implicated in the regulation of a growing number of physiological and pathological…”
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CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development by Melese, Etienne S., Franks, Elizabeth, Cederberg, Rachel A., Harbourne, Bryant T., Shi, Rocky, Wadsworth, Brennan J., Collier, Jenna L., Halvorsen, Elizabeth C., Johnson, Fraser, Luu, Jennifer, Oh, Min Hee, Lam, Vivian, Krystal, Gerald, Hoover, Shelley B., Raffeld, Mark, Simpson, R. Mark, Unni, Arun M., Lam, Wan L., Lam, Stephen, Abraham, Ninan, Bennewith, Kevin L., Lockwood, William W.

“…Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers…”
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A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation by HO, Victor W, LEUNG, Kelvin, NELSON, Brad H, SLY, Laura M, KRYSTAL, Gerald, HSU, Anderson, LUK, Beryl, LAI, June, SUNG YUAN SHEN, MINCHINTON, Andrew I, WATERHOUSE, Dawn, BAL LY, Marcel B, LIN, Wendy

“…Since cancer cells depend on glucose more than normal cells, we compared the effects of low carbohydrate (CHO) diets to a Western diet on the growth rate of…”
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SHIP Represses the Generation of IL-3-Induced M2 Macrophages by Inhibiting IL-4 Production from Basophils by Kuroda, Etsushi, Ho, Victor, Ruschmann, Jens, Antignano, Frann, Hamilton, Melisa, Rauh, Michael J, Antov, Andrey, Flavell, Richard A, Sly, Laura M, Krystal, Gerald

“…There is a great deal of interest in determining what regulates the generation of classically activated (M1) vs alternatively activated (M2) macrophages…”
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UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells by Samudio, Ismael, Rezvani, Katayoun, Shaim, Hila, Hofs, Elyse, Ngom, Mor, Bu, Luke, Liu, Guoyu, Lee, Jason T.C., Imren, Suzan, Lam, Vivian, Poon, Grace F.T., Ghaedi, Maryam, Takei, Fumio, Humphries, Keith, Jia, William, Krystal, Gerald

“…Herein we demonstrate that oncolytic herpes simplex virus-1 (HSV-1) potently activates human peripheral blood mononuclear cells (PBMCs) to lyse leukemic cell…”
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All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages by Ho, Victor W, Hofs, Elyse, Elisia, Ingrid, Lam, Vivian, Hsu, Brian E, Lai, June, Luk, Beryl, Samudio, Ismael, Krystal, Gerald

“…In previous studies we found that macrophages (MФs) from SH2-containing inositol-5'-phosphatase (SHIP) deficient mice are M2 polarized while their wild type…”
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SHIP Represses the Generation of Alternatively Activated Macrophages by Rauh, Michael J., Ho, Victor, Pereira, Carla, Sham, Anita, Sly, Laura M., Lam, Vivian, Huxham, Lynsey, Minchinton, Andrew I., Mui, Alice, Krystal, Gerald

“…We recently reported that SHIP restrains LPS-induced classical (M1) activation of in vitro differentiated, bone marrow-derived macrophages (BMMΦs) and that…”
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LPS-Induced Upregulation of SHIP Is Essential for Endotoxin Tolerance by Sly, Laura M., Rauh, Michael J., Kalesnikoff, Janet, Song, Christine H., Krystal, Gerald

“…An initial exposure to lipopolysaccharide (LPS) induces a transient state of hyporesponsiveness to a subsequent challenge with LPS. The mechanism underlying…”
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Corrigendum to “Wild Chaga (Inonotus obliquus) modulates inflammation, neural cell survival and inhibits proliferation of cancer cells” [Pharmacological Research - Modern Chinese Medicine 9C (2023) /100328] by Cheung, Susan SC, Chong, Garyen, Elisia, Ingrid, Hasman, David, Lee, Martin, Chang, Linda, Ao, Ziliang, Khelifi, Djamel, Krystal, Gerald, Tai, Joseph

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Editorial: The Effect of Carbohydrate Restriction on Cancer and Metabolic Syndrome by Elisia, Ingrid, Santosa, Sylvia, Popovich, David G, Krystal, Gerald

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Macrophages are more potent immune suppressors ex vivo than immature myeloid-derived suppressor cells induced by metastatic murine mammary carcinomas by Hamilton, Melisa J, Bosiljcic, Momir, Lepard, Nancy E, Halvorsen, Elizabeth C, Ho, Victor W, Banáth, Judit P, Krystal, Gerald, Bennewith, Kevin L

“…Myeloid-derived suppressor cells (MDSCs) are emerging as potential promoters of metastatic tumor growth, and there is interest in targeting immature MDSCs by…”
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A low carbohydrate diet high in fish oil and soy protein delays inflammation, hematopoietic stem cell depletion, and mortality in miR-146a knock-out mice by Elisia, Ingrid, Kowalski, Sara, Yeung, Michelle, Wong, Jennifer, Grants, Jennifer M, Karsan, Aly, Krystal, Gerald

“…Since our previous studies found a low carbohydrate (CHO) diet containing soy protein and fish oil (15%Amylose/Soy/FO) significantly reduced lung and breast…”
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Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells by Ong, Christopher J., Ming-Lum, Andrew, Nodwell, Matt, Ghanipour, Ali, Yang, Lu, Williams, David E., Kim, Joseph, Demirjian, Loutfig, Qasimi, Pooran, Ruschmann, Jens, Cao, Li-Ping, Ma, Kewei, Chung, Stephen W., Duronio, Vincent, Andersen, Raymond J., Krystal, Gerald, Mui, Alice L.-F.

“…Because phosphoinositide 3-kinase (PI3K) plays a central role in cellular activation, proliferation, and survival, pharmacologic inhibitors targeting…”
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