Search Results - "KRUYT, F. A. E"

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family by Azijli, K, Weyhenmeyer, B, Peters, G J, de Jong, S, Kruyt, F A E

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapy is currently evaluated in clinical studies as a tumor cell selective…”
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Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor by Hiltermann, T.J.N., Pore, M.M., van den Berg, A., Timens, W., Boezen, H.M., Liesker, J.J.W., Schouwink, J.H., Wijnands, W.J.A., Kerner, G.S.M.A., Kruyt, F.A.E., Tissing, H., Tibbe, A.G.J., Terstappen, L.W.M.M., Groen, H.J.M.

“…Initial response of small-cell lung cancer (SCLC) to chemotherapy is high, and recurrences occur frequently, leading to early death. This study investigated…”
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Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown by RODRIGUEZ, J. A, LENS, S. M. A, SPAN, S. W, VADER, G, MEDEMA, R. H, KRUYT, F. A. E, GIACCONE, G

“…As mitosis progresses, the chromosomal passenger proteins (CPPs) Survivin, Aurora B, INCENP and Borealin dynamically colocalize to mitotic structures…”
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Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors by Bijnsdorp, I V, Capriotti, F, Kruyt, F A E, Losekoot, N, Fukushima, M, Griffioen, A W, Thijssen, V L, Peters, G J

“…Background: Thymidine phosphorylase (TP) is often overexpressed in tumours and has a role in tumour aggressiveness and angiogenesis. Here, we determined…”
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Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL by Meijer, A, Kruyt, F A E, van der Zee, A G J, Hollema, H, Le, P, ten Hoor, K A, Groothuis, G M M, Quax, W J, de Vries, E G E, de Jong, S

“…Background: Tumour cell-selective activation of apoptosis by recombinant human TNF-related apoptosis-inducing ligand (rhTRAIL) is enhanced through…”
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The Summer School Oncology Groningen: Improving a Successful International Course by Refining the Old, Maintaining What’s Good by Boske, E. C. E., Nienhuis, P. H., Hammer, C., Jalving, M., Kruyt, F. A. E., de Vries, J., Roodenburg, J. L. N., Metman, M. J. H., Kruijff, S.

“…For more than two decades, the International Summer School Oncology for Medical Students (ISOMS) has organized a biennial 2-week international summer school…”
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Inhibition of formyl peptide receptor in high-grade astrocytoma by CHemotaxis Inhibitory Protein of S. aureus by Boer, J C, Domanska, U M, Timmer-Bosscha, H, Boer, I G J, de Haas, C J C, Joseph, J V, Kruyt, F A E, de Vries, E G E, den Dunnen, W F A, van Strijp, J A G, Walenkamp, A M E

“…Background: High-grade astrocytomas are malignant brain tumours that infiltrate the surrounding brain tissue and have a poor prognosis. Activation of formyl…”
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Microenvironment involved in FPR1 expression by human glioblastomas by Boer, J. C., van Marion, D. M. S., Joseph, J. V., Kliphuis, N. M., Timmer-Bosscha, H., van Strijp, J. A. G., de Vries, E. G. E., den Dunnen, W. F. A., Kruyt, F. A. E., Walenkamp, A. M. E.

“…Formyl peptide receptor 1 (FPR1) activity in U87 glioblastoma (GBM) cells contributes to tumor cell motility. The present study aimed to evaluate the FPR1…”
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Nuclear localization of survivin is a positive prognostic factor for survival in advanced non-small-cell lung cancer by Vischioni, B., van der Valk, P., Span, S. W., Kruyt, F. A. E., Rodriguez, J. A., Giaccone, G.

“…Background: Expression of survivin, a member of the inhibitor of apoptosis protein family, is commonly detected in cancers but not in normal differentiated…”
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Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells by Bijnsdorp, I.V., Azijli, K., Jansen, E.E., Wamelink, M.M., Jakobs, C., Struys, E.A., Fukushima, M., Kruyt, F.A.E., Peters, G.J.

“…Thymidine (TdR) is converted by thymidine phosphorylase (TP) to deoxyribose-1-phosphate (dR-1-P), which can enter various metabolic pathways, which potentially…”
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Paclitaxel and vincristine potentiate adenoviral oncolysis that is associated with cell cycle and apoptosis modulation, whereas they differentially affect the viral life cycle in non-small-cell lung cancer cells by AbouEl Hassan, M A I, Braam, S R, Kruyt, F A E

“…Chemotherapy, including microtubule (MT)-interacting agents, can enhance the tumor-eradicating activity of replication-competent adenoviruses. The purpose of…”
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TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion by Joseph, J V, Conroy, S, Tomar, T, Eggens-Meijer, E, Bhat, K, Copray, S, Walenkamp, A M E, Boddeke, E, Balasubramanyian, V, Wagemakers, M, den Dunnen, W F A, Kruyt, F A E

“…Different molecular subtypes of glioblastoma (GBM) have been recently identified, of which the mesenchymal subtype is associated with worst prognoses. Here, we…”
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Caspase-dependent and -independent suppression of apoptosis by monoHER in Doxorubicin treated cells by BRUYNZEEL, A. M. E, ABOU EL HASSAN, M. A, TORUN, E, BAST, A, VAN DER VIJGH, W. J. F, KRUYT, F. A. E

“…Doxorubicin (DOX) is an antitumour agent for different types of cancer, but the dose-related cardiotoxicity limits its clinical use. To prevent this side…”
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Immunohistochemical detection of nuclear survivin in NSCLC: a comparison of commercial antibodies by Vischioni, B, Oudejans, J J, Kruyt, F A E, Giaccone, G, Rodriguez, J A

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Bortezomib and TRAIL: A perfect match for apoptotic elimination of tumour cells? by de Wilt, L.H.A.M, Kroon, J, Jansen, G, de Jong, S, Peters, G.J, Kruyt, F.A.E

“…Abstract Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that selectively eradicates tumour cells via specific cell surface…”
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SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery by Dijkstra, B. M., Motekallemi, A., den Dunnen, W. F. A., Jeltema, J. R., van Dam, G. M., Kruyt, F. A. E., Groen, R. J. M.

“…Background Meningiomas are the most frequently occurring primary intracranial tumours in adults. Surgical removal can only be curative by complete resection;…”
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TRAIL receptor targeting therapies for non-small cell lung cancer: Current status and perspectives by Stegehuis, J.H, de Wilt, L.H.A.M, de Vries, E.G.E, Groen, H.J, de Jong, S, Kruyt, F.A.E

“…Abstract Non-small cell lung cancer (NSCLC) is a common and often fatal malignancy, diagnosed at an advanced stage in more than half of the cases…”
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Embryological signaling pathways in Barrett's metaplasia development and malignant transformation; mechanisms and therapeutic opportunities by Pavlov, K, Meijer, C, van den Berg, A, Peters, F.T.M, Kruyt, F.A.E, Kleibeuker, J.H

“…Abstract Barrett's metaplasia of the esophagus (BE) is the precursor lesion of esophageal adenocarcinoma (EAC), a deadly disease with a 5-year overall survival…”
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Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients by Ferreira, C. G., van der Valk, P., Span, S. W., Jonker, J. M., Postmus, P. E., Kruyt, F. A. E., Giaccone, G.

“…Summary Background: Expression of inhibitor of apoptosis family proteins (IAPs) has been shown in vitro to decrease chemosensitivity through caspase…”
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Overexpression of Bcl2 abrogates chemo- and radiotherapy-induced sensitisation of NCI-H460 non-small-cell lung cancer cells to adenovirus-mediated expression of full-length TRAIL by Abou El Hassan, M A I, Mastenbroek, D C J, Gerritsen, W R, Giaccone, G, Kruyt, F A E

“…TNF-related apoptosis-inducing ligand (TRAIL, also known as Apo-2L) is a promising novel anticancer agent that selectively induces apoptosis in tumour cells…”
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