Search Results - "KRUGERS, H. J"

The Consequences of Early-Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations by Maccari, S., Krugers, H. J., Morley-Fletcher, S., Szyf, M., Brunton, P. J.

“…During the perinatal period, the brain is particularly sensitive to remodelling by environmental factors. Adverse early‐life experiences, such as stress…”
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Stress and excitatory synapses: From health to disease by Timmermans, W, Xiong, H, Hoogenraad, C.C, Krugers, H.J

“…Highlights • Stress can result in highly adaptive responses but is also an important risk factor for disease. • Acute stress rapidly enhances excitatory…”
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Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients by Wang, Q., Verweij, E. W. E., Krugers, H. J., Joels, M., Swaab, D. F., Lucassen, P. J.

“…Exposure to stress activates the hypothalamic–pituitary–adrenal (HPA) axis that stimulates glucocorticoid (GC) release from the adrenal. These hormones exert…”
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Blockade of glucocorticoid receptors rapidly restores hippocampal CA1 synaptic plasticity after exposure to chronic stress by Krugers, H. J., Goltstein, P. M., Van Der Linden, S., Joëls, M.

“…Prolonged exposure to stressful events has been reported to inhibit the ability of hippocampal synapses to increase their synaptic efficacy. Here we tested if…”
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Within-litter variation in maternal care received by individual pups correlates with adolescent social play behavior in male rats by van Hasselt, F.N, Tieskens, J.M, Trezza, V, Krugers, H.J, Vanderschuren, L.J.M.J, Joëls, M

“…Abstract Maternal care represents an essential environmental factor during the first post-natal week(s) of rodents and is known to have lasting consequences…”
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Maternal Care Received by Individual Pups Correlates with Adult CA1 Dendritic Morphology and Synaptic Plasticity in a Sex-Dependent Manner by van Hasselt, F. N., Boudewijns, Z. S. R. M., van der Knaap, N. J. F., Krugers, H. J., Joëls, M.

“…Maternal care is an important environmental factor for rats early in life. Adult offspring from dams exhibiting extremely high versus low maternal care differ…”
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Corticosterone and stress reduce synaptic potentiation in mouse hippocampal slices with mild stimulation by Alfarez, D.N, Wiegert, O, Joëls, M, Krugers, H.J

“…Elevation of circulating corticosterone levels, either through exogenous administration of the hormone or following stress exposure, is known to reduce…”
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Increasing the statistical power of animal experiments with historical control data by Bonapersona, V., Hoijtink, H., Sarabdjitsingh, R. A., Joëls, M.

“…Low statistical power reduces the reliability of animal research; yet, increasing sample sizes to increase statistical power is problematic for both ethical…”
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Changes in perceived ageism during the COVID-19 pandemic: impact on quality of life and mental well-being among Dutch adults aged 55 and older by Brinkhof, Lotte P., Murre, J. M. J., de Wit, S., Krugers, H. J., Ridderinkhof, K. R.

“…Objectives: The COVID-19 pandemic brought ageism to the forefront of public discourse. Negative ageism incurs more negative self-perceptions of aging, which…”
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A single social stress-experience alters glutamate receptor-binding in rat hippocampal CA3 area by Krugers, H J, Koolhaas, J M, Bohus, B, Korf, J

“…The distribution of glutamate receptors in the rat hippocampus was investigated 24 h after the social stress of confrontation with a dominant opponent…”
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Opposite effects of glucocorticoid receptor activation on hippocampal CA1 dendritic complexity in chronically stressed and handled animals by Alfarez, D.N., Karst, H., Velzing, E.H., Joëls, M., Krugers, H.J.

“…Remodeling of synaptic networks is believed to contribute to synaptic plasticity and long‐term memory performance, both of which are modulated by chronic…”
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Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice by Krugers, Harm J, Mulder, Monique, Korf, Jakob, Havekes, Louis, de Kloet, E Ronald, Joëls, Marian

“…IN mice with a homozygous or heterozygous deficiency for ApoE as well as in wild-type animals we established synaptic responsiveness in the hippocampal CA1…”
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Down-regulation of the hypothalamo-pituitary-adrenal axis reduces brain damage and number of seizures following hypoxia/ischaemia in rats by Krugers, Harm J., Knollema, Siert, Kemper, Richard H.A., Ter Horst, Gert J., Korf, Jakob

“…Several reports suggest that the activity of the hypothalamo-pituitary-adrenal axis (HPA-axis) is increased following hypoxia/ischaemia and that this might be…”
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Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels? by Krugers, H J, Kemper, R H, Korf, J, Ter Horst, G J, Knollema, S

“…Hypoxia-ischemia is accompanied by abundant corticosterone secretion that could exacerbate brain damage after the insult. The authors demonstrate that the…”
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Postischemic Steroid Modulation: Effects on Hippocampal Neuronal Integrity and Synaptic Plasticity by Krugers, Harm J., Maslam, Suharti, Van Vuuren, Sandra M., Korf, Jakob, Joëls, Marian

“…Elimination of corticosteroids after ischemia, by removal of the adrenals, has been reported to preserve neuronal integrity later. To establish the therapeutic…”
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Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats by Krugers, H.J., van der Linden, S., van Olst, E., Alfarez, D.N., Maslam, S., Lucassen, P.J., Joëls, M.

“…Removal of adrenal hormone corticosterone in rats aged 3–4 months results within 3 days in acceleration of apoptosis and proliferation of newborn cells in the…”
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Prolonged subordination stress increases Calbindin-D28k immunoreactivity in the rat hippocampal CA1 area by Krugers, Harm J., Koolhaas, Jaap M., Medema, Rikje M., Korf, Jakob

“…Previously we observed that corticosteroids alter Calbindin-D28k immunoreactivity in the rat hippocampus. In the present study we investigated whether…”
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Region-specific alterations of calbindin-D28k immunoreactivity in the rat hippocampus following adrenalectomy and corticosterone treatment by Krugers, Harm J., Medema, Rikje M., Postema, Folkert, Korf, Jakob

“…The aim of this study was (i) to compare the immunocytochemical distribution of the calcium-binding protein calbindin-D28k (CB) in the hippocampus of rats with…”
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The effect of theophylline and immobilization stress on haloperidol-induced catalepsy and on metabolism in the striatum and hippocampus, studied with lactography by Dijk, S, Krugers, H J, Korf, J

“…Whether inducing catalepsy in the rat by an intraperitoneal injection of haloperidol (0.5 mg/kg) had an effect on metabolism in the striatum and in the…”
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Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell loss by Postigo, J.Antonio, Van der Werf, Ysbrand D, Korf, Jakob, Krugers, Harm J

“…The loss of dentate gyrus (DG) granular cells after removal of the rat adrenal glands (ADX) is mediated by a process that is apoptotic in nature. The present…”
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