Search Results - "KROPSHOFER, H"

Taking immunogenicity assessment of therapeutic proteins to the next level by Büttel, I.C., Chamberlain, P., Chowers, Y., Ehmann, F., Greinacher, A., Jefferis, R., Kramer, D., Kropshofer, H., Lloyd, P., Lubiniecki, A., Krause, R., Mire-Sluis, A., Platts-Mills, T., Ragheb, J.A., Reipert, B.M., Schellekens, H., Seitz, R., Stas, P., Subramanyam, M., Thorpe, R., Trouvin, J.-H., Weise, M., Windisch, J., Schneider, C.K.

“…Therapeutic proteins provide innovative and effective therapies for numerous diseases. However, some of these products are associated with unwanted…”
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Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes by Kropshofer, H, Spindeldreher, S, Röhn, T. A, Platania, N, Grygar, C, Daniel, N, Wölpl, A, Langen, H, Horejsi, V, Vogt, A. B

“…Complexes of peptide and major histocompatibility complex (MHC) class II are expressed on the surface of antigen-presenting cells but their molecular…”
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Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization by Kropshofer, Harald, Röhn, Till A, Boes, Marianne, Wolters, Dirk, Spindeldreher, Sebastian, Müller, Bernd, Langen, Hanno, Ploegh, Hidde, Vogt, Anne B

“…Dendritic cells (DCs) initiate and regulate immunity against foreign and self antigens. Here we identified more than 200 individual major histocompatibility…”
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Editing of the HLA‐DR‐peptide repertoire by HLA‐DM by Kropshofer, H, Vogt, A. B, Moldenhauer, G, Hammer, J, Blum, J. S, Hämmerling, G. J

“…Antigenic peptide loading of classical major histocompatibility complex (MHC) class II molecules requires the exchange of the endogenous invariant chain…”
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A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules by Kropshofer, Harald, Vogt, Anne B., Thery, Clotilde, Armandola, Elena A., Li, Bi-Chen, Moldenhauer, Gerhard, Amigorena, Sebastian, Hämmerling, Günter J.

“…In B cells, the non‐classical human leukocyte antigens HLA‐DO (DO) and HLA‐DM (DM) are residents of lysosome‐like organelles where they form tight complexes…”
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Ligand motifs of HLA-DRB50101 and DRB11501 molecules delineated from self-peptides by Vogt, AB, Kropshofer, H, Kalbacher, H, Kalbus, M, Rammensee, HG, Coligan, JE, Martin, R

“…Antigenic peptides are presented to CD4+ T cells by MHC class II molecules via a highly polymorphic peptide-binding groove. The two HLA-DR alleles isotypically…”
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Kinetic Analysis of Peptide Loading onto HLA-DR Molecules Mediated by HLA-DM by Vogt, Anne B., Kropshofer, Harald, Moldenhauer, Gerhard, Hämmerling, Günter J.

“…The nonclassical major histocompatibility complex class II molecule HLA-DM (DM) has recently been shown to play a central role in the class II-associated…”
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Structural Features of the Invariant Chain Fragment CLIP Controlling Rapid Release from HLA-DR Molecules and Inhibition of Peptide Binding by Kropshofer, Harald, Vogt, Anne B., Hammerling, Gunter J.

“…The invariant chain (Ii) prevents binding of ligands to major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum and during…”
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Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif by KROPSHOFER, H, MAX, H, MÜLLER, C. A, HESSE, F, STEVANOVIC, S, JUNG, G, KALBACHER, H

“…Peptide fragments of foreign and self-proteins are of great immunologic importance as their binding to major histocompatibility complex (MHC) class I or II…”
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New TRP-2-derived T helper epitopes identified in HLA-DRB10301 transgenic mice elicit spontaneous T cell responses in HLA-DRB103 and HLA-DRB104 melanoma patients by Song, M, Osen, W, Thomas, D, Daniel, N, Nguyen, XD, Mueller-Berghaus, J, Kropshofer, H, Schadendorf, D, Paschen, A

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Clustering of MHC-peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains by Vogt, Anne B., Spindeldreher, Sebastian, Kropshofer, Harald

“…Protein reorganization at the interface of a T cell and an antigen‐presenting cell (APC) plays an important role in T cell activation. Imaging techniques…”
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Evidence for Cobinding of Self- and Allopeptides to Human Class II Major Histocompatibility Antigen DR1 by Energy Transfer by Kropshofer, Harald, Max, Heiner, Kalbacher, Hubert

“…Purified human class II major histocompatibility antigen HLA-DR1 was subjected to high-performance gel filtration with fluorescence detection to investigate…”
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Recruitment of MHC Class I Molecules by Tapasin into the Transporter Associated with Antigen Processing-Associated Complex Is Essential for Optimal Peptide Loading by Tan, Pamela, Kropshofer, Harald, Mandelboim, Ofer, Bulbuc, Nadja, Hammerling, Gunter J, Momburg, Frank

“…The ER protein tapasin (Tpn) forms a bridge between MHC class I H chain (HC)/beta(2)-microglobulin and the TAP peptide transporter. The function of this…”
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A novel strategy for the discovery of MHC class II-restricted tumor antigens : Identification of a melanotransferrin helper T-cell epitope by RÖHN, Till A, REITZ, Annette, PASCHEN, Annette, NGUYEN, Xuan D, SCHADENDORF, Dirk, VOGT, Anne B, KROPSHOFER, Harald

“…CD4+ helper T cells play a critical role in orchestrating host immune responses, including antitumor immunity. The limited availability of MHC class…”
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Association of HLA and multiple sclerosis by Martin, R, Vogt, A B, Kropshofer, H, Lichtenfels, R

“…Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system. Although the cause of MS is still unknown, it is considered an autoimmune…”
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International multi-site analytical validation of the Simoa NF-light assay in human serum samples from multiple sclerosis patients by Kuhle, J, Barro, C, Hrusovsky, K, Chang, L, Jeromin, A, Bridel, C, Bar-Or, A, Bittner, S, Bruck, W, Bielekova, B, Chitnis, T, Comi, G, Comabella, M, Arrambide, G, Montalban, X, Datwani, A, Fluck, M, Fox, R, Freedman, M, Furlan, R, Gnanapavan, S, Giovannoni, G, Havari, E, Khalil, M, Leppert, D, Kropshofer, H, Valentin, MA, Oksenberg, J, Piehl, F, Plavina, T, Sormani, MP, Lehmann, S, Thouvenot, E, Ziemssen, T, Zipp, F, Gross, C, Wiendl, H, Kappos, L, Michalak, Z, Blennow, K, Zetterberg, H, Teunissen, C, Wilson, D

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HLA-DM Acts as a Molecular Chaperone and Rescues Empty HLA-DR Molecules at Lysosomal pH by Kropshofer, Harald, Arndt, Sven O, Moldenhauer, Gerhard, Hämmerling, Günter J, Vogt, Anne B

“…HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is…”
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The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules by Kropshofer, Harald, Hämmerling, Günter J., Vogt, Anne B.

“…Peptide binding to classical major histocompatibility complex (MHC) class II molecules is known to be determined by the properties of the class ii peptide…”
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The role of HLA-DM for loading and selection of the peptide repertoire of MHC class-II molecules by Kropshofer, H

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Deficient Peptide Loading and MHC Class II Endosomal Sorting in a Human Genetic Immunodeficiency Disease: The Chediak-Higashi Syndrome by Faigle, Wolfgang, Raposo, Graça, Tenza, Daniele, Pinet, Valérie, Vogt, Anne B., Kropshofer, Harald, Fischer, Alain, de Saint-Basile, Geneviève, Amigorena, Sebastian

“…The Chediak-Higashi syndrome (CHS) is a human recessive autosomal disease caused by mutations in a single gene encoding a protein of unknown function, called…”
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