Search Results - "KROMMINGA, Arno"

Serum autoreactivity predicts time to response to omalizumab therapy in chronic spontaneous urticaria by Gericke, Janine, PhD, Metz, Martin, MD, Ohanyan, Tatevik, MD, Weller, Karsten, MD, Altrichter, Sabine, MD, Skov, Per Stahl, MD, Falkencrone, Sidsel, PhD, Brand, Janko, PhD, Kromminga, Arno, PhD, Hawro, Tomasz, MD, Church, Martin K., PhD, DSc, Maurer, Marcus, MD

“…The cutoff time of 8 days between fast and slow responders was chosen because it corresponds with the peak plasma level of omalizumab after its initial…”
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Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria: Results of the PURIST Study by Schoepke, Nicole, Asero, Riccardo, Ellrich, André, Ferrer, Marta, Gimenez‐Arnau, Ana, E. H. Grattan, Clive, Jakob, Thilo, Konstantinou, George N., Raap, Ulrike, Skov, Per Stahl, Staubach, Petra, Kromminga, Arno, Zhang, Ke, Bindslev‐Jensen, Carsten, Daschner, Alvaro, Kinaciyan, Tamar, Knol, Edward F., Makris, Michael, Marrouche, Nadine, Schmid‐Grendelmeier, Peter, Sussman, Gordon, Toubi, Elias, Church, Martin K., Maurer, Marcus

“…Background Autoimmune chronic spontaneous urticaria (aiCSU) is an important subtype of chronic spontaneous urticaria (CSU) in which functional IgG…”
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Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol by Ito, Natsuho, Ito, Taisuke, Kromminga, Arno, Bettermann, Albrecht, Takigawa, Masahiro, Kees, Frieder, Straub, Rainer H, Paus, Ralf

“…ABSTRACTThe skin and its major appendages are prominent target organs and potent sources of key players along the classical hypothalamic‐pituitary axis, such…”
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Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria by Kolkhir, Pavel, Altrichter, Sabine, Asero, Riccardo, Daschner, Alvaro, Ferrer, Marta, Giménez-Arnau, Ana, Hawro, Tomasz, Jakob, Thilo, Kinaciyan, Tamar, Kromminga, Arno, Konstantinou, George N, Makris, Michael, Metz, Martin, Skov, Per Stahl, Staubach, Petra, Sussman, Gordon, Zhang, Ke, Maurer, Marcus

“…Purpose Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of…”
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Endocannabinoids limit excessive mast cell maturation and activation in human skin by Sugawara, Koji, MD, PhD, Bíró, Tamás, MD, PhD, Tsuruta, Daisuke, MD, PhD, Tóth, Balázs I., PhD, Kromminga, Arno, PhD, Zákány, Nóra, MS, Zimmer, Anne, Funk, Wolfgang, MD, Gibbs, Bernhard F., PhD, Zimmer, Andreas, PhD, Paus, Ralf, MD

“…Background Mast cells (MCs) crucially contribute to many inflammatory diseases. However, the physiological controls preventing excessive activities of MCs in…”
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Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals by Tourdot, Sophie, Baltrunkonis, Daniel, Denies, Sofie, Devanarayan, Viswanath, Grudzinska-Goebel, Joanna, Kromminga, Arno, Lotz, Gregor P, Malherbe, Laurent, Michaut, Lydia, Weldingh, Karin N, Pedras-Vasconcelos, Joao A, Salazar-Fontana, Laura I, Spindeldreher, Sebastian, Sauna, Zuben, Snoeck, Veerle, Verthelyi, Daniela, Kramer, Daniel

“…Biologics have revolutionized disease management in many therapeutic areas by addressing unmet medical needs and overcoming resistance to standard-of-care…”
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Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation by van Beek, Nina, Bodó, Enikő, Kromminga, Arno, Gáspár, Erzsébet, Meyer, Katja, Zmijewski, Michal A., Slominski, Andrzej, Wenzel, Björn E., Paus, Ralf

“…Context: Both insufficient and excess levels of thyroid hormones (T3 and T4) can result in altered hair/skin structure and function (e.g. effluvium). However,…”
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Autoantibody Detection Using Indirect Immunofluorescence on HEp-2 Cells by Sack, Ulrich, Conrad, Karsten, Csernok, Elena, Frank, Ingrid, Hiepe, Falk, Krieger, Thorsten, Kromminga, Arno, Von Landenberg, Philipp, Messer, Gerald, Witte, Torsten, Mierau, Rudolf

“…The detection of autoantibodies is an important element in the diagnosis and monitoring of disease progression in patients with autoimmune diseases. In…”
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Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones by Bodó, Enikő, Kany, Benedikt, Gáspár, Erzsébet, Knüver, Jana, Kromminga, Arno, Ramot, Yuval, Bíró, Tamás, Tiede, Stephan, van Beek, Nina, Poeggeler, Burkhard, Meyer, Katja C, Wenzel, Björn E, Paus, Ralf

“…Several elements of the hypothalamic-pituitary-thyroid axis (HPT) reportedly are transcribed by human skin cell populations, and human hair follicles express…”
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Antibodies against Erythropoietin and Other Protein-Based Therapeutics: An Overview by KROMMINGA, ARNO, SCHELLEKENS, HUUB

“…: Many factors influence the immunogenicity of protein‐based therapeutics. At present, it is inconceivable to manufacture a biopharmaceutical without the risk…”
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Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria by Kolkhir, Pavel, Altrichter, Sabine, Asero, Riccardo, Daschner, Alvaro, Ferrer, Marta, Giménez-Arnau, Ana, Hawro, Tomasz, Jakob, Thilo, Kinaciyan, Tamar, Kromminga, Arno, Konstantinou, George N, Makris, Michael, Metz, Martin, Skov, Per Stahl, Staubach, Petra, Sussman, Gordon, Zhang, Ke, Maurer, Marcus

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Current Considerations on Characterization of Immune Response to Multi-Domain Biotherapeutics by Gorovits, Boris, Peng, Kun, Kromminga, Arno

“…Compounds containing two or more structural domains with a distinct mode of action relevant to functionality have been defined as multi-domain biotherapeutics…”
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Subclass distribution of type VII collagen-specific autoantibodies in patients with inflammatory bowel disease by Oostingh, Gertie Janneke, Sitaru, Cassian, Kromminga, Arno, Lührs, Hardi, Zillikens, Detlef

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Cicatricial pemphigoid differs from bullous pemphigoid and pemphigoid gestationis regarding the fine specificity of autoantibodies to the BP180 NC16A domain by Kromminga, Arno, Sitaru, Cassian, Meyer, Jutta, Arndt, Rüdiger, Schmidt, Enno, Christophers, Enno, Bröcker, Eva-B, Zillikens, Detlef

“…Bullous pemphigoid (BP), pemphigoid (herpes) gestationis (PG), cicatricial pemphigoid (CP), and lichen planus pemphigoides (LPP) are autoimmune subepidermal…”
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Managing unwanted immunogenicity of biologicals by Deehan, Maureen, Garcês, Sandra, Kramer, Daniel, Baker, Matthew P, Rat, Dorothea, Roettger, Yvonne, Kromminga, Arno

“…Abstract All protein drugs (biologicals) have an immunogenic potential and we are armed with multiple guidelines, regulatory documents and white papers to…”
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The quintessence of immunogenicity reporting for biotherapeutics by Shankar, Gopi, Arkin, Steven, Devanarayan, Viswanath, Kromminga, Arno, Quarmby, Valerie, Richards, Susan, Subramanyam, Meena, Swanson, Steven

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Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein by Curtin, François, Perron, Hervé, Kromminga, Arno, Porchet, Hervé, Lang, Alois B

“…Monoclonal antibodies (mAbs) play an increasing important role in the therapeutic armamentarium against multiple sclerosis (MS), an inflammatory and…”
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The European Bioanalysis Forum recommendation on establishing appropriate drug tolerance levels in antidrug antibody assays by Cowan, Kyra J, Champion, Lysie, Dyer, Daniel, Carlsen, Morten Funch, Geary, Laura, Genin, Jean-Christophe, Golob, Michaela, Goodman, Joanne, Kromminga, Arno, Nelson, Rob, Revell, Heather, Rieger, Martin, Van de Vyver, Ortwin, Venema, Foka, Timmerman, Philip

“…The European Bioanalysis Forum, in collaboration with several key industry stakeholders, has recently led discussions that address international immunogenicity…”
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B cell epitopes on infliximab identified by oligopeptide microarray with unprocessed patient sera by Homann, Arne, Röckendorf, Niels, Kromminga, Arno, Frey, Andreas, Jappe, Uta

“…Autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease are treated with TNF-alpha-blocking antibodies such as infliximab and adalimumab…”
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2020 White Paper on Recent Issues in Bioanalysis: Vaccine Assay Validation, qPCR Assay Validation, QC for CAR-T Flow Cytometry, NAb Assay Harmonization and ELISpot Validation by Corsaro, Bart, Yang, Tong-yuan, Murphy, Rocio, Sonderegger, Ivo, Exley, Andrew, Bertholet, Sylvie, Dakappagari, Naveen, Dessy, Francis, Garofolo, Fabio, Kierstead, Lisa, Koch, Holger, Sarikonda, Ghanashyam, Savoie, Natasha, Siggers, Richard, Solstad, Therese, Lu, Yanmei, Milton, Mark, Marshall, Jean-Claude, DelCarpini, Jason, Gorovits, Boris, Gupta, Swati, Jesaitis, Lynne, Kamerud, John, Kromminga, Arno, Ma, Anna, McNally, Jim, Yan, Haoheng, Wu, Bonnie, Verthelyi, Daniela, Kirshner, Susan, Pedras-Vasconcelos, Joao, Rajadhyaksha, Manoj, Staack, Roland F., Cherry, Elana, Cludts, Isabelle, Dahlbäck, Madeleine, Gunn, George R., Ishii-Watabe, Akiko, Jawa, Vibha, Kubiak, Robert, Partridge, Michael, Petrillo, Marco, Pine, Samuel O., Poetzl, Johann, Song, Sam, Stebbins, Chris, Wu, Yuling, Zhang, Lucia, Kar, Sumit, Liang, Meina, Abhari, Mohsen Rajabi, Schweighardt, Becky, Stubenrauch, Kay, Xu, Yuanxin

“…The 14 edition of the Workshop on Recent Issues in Bioanalysis (14 WRIB) was held virtually on June 15-29, 2020 with an attendance of over 1000 representatives…”
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