Search Results - "KROISS, Matthias"

Update in Adrenocortical Carcinoma by Fassnacht, Martin, Kroiss, Matthias, Allolio, Bruno

“…Adrenocortical carcinoma (ACC) is an orphan malignancy that has attracted increasing attention during the last decade. Here we provide an update on advances in…”
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Personalized Management of Pheochromocytoma and Paraganglioma by Nölting, Svenja, Bechmann, Nicole, Taieb, David, Beuschlein, Felix, Fassnacht, Martin, Kroiss, Matthias, Eisenhofer, Graeme, Grossman, Ashley, Pacak, Karel

“…Abstract Pheochromocytomas/paragangliomas are characterized by a unique molecular landscape that allows their assignment to clusters based on underlying…”
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The landscape of chromothripsis across adult cancer types by Voronina, Natalia, Wong, John K. L., Hübschmann, Daniel, Hlevnjak, Mario, Uhrig, Sebastian, Heilig, Christoph E., Horak, Peter, Kreutzfeldt, Simon, Mock, Andreas, Stenzinger, Albrecht, Hutter, Barbara, Fröhlich, Martina, Brors, Benedikt, Jahn, Arne, Klink, Barbara, Gieldon, Laura, Sieverling, Lina, Feuerbach, Lars, Chudasama, Priya, Beck, Katja, Kroiss, Matthias, Heining, Christoph, Möhrmann, Lino, Fischer, Andrea, Schröck, Evelin, Glimm, Hanno, Zapatka, Marc, Lichter, Peter, Fröhling, Stefan, Ernst, Aurélie

“…Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of…”
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Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma by Dierks, Christine, Seufert, Jochen, Aumann, Konrad, Ruf, Juri, Klein, Claudius, Kiefer, Selina, Rassner, Michael, Boerries, Melanie, Zielke, Andreas, la Rosee, Paul, Meyer, Philipp Tobias, Kroiss, Matthias, Weißenberger, Christian, Schumacher, Tilmann, Metzger, Patrick, Weiss, Harald, Smaxwil, Constantin, Laubner, Katharina, Duyster, Justus, von Bubnoff, Nikolas, Miething, Cornelius, Thomusch, Oliver

“…Anaplastic thyroid carcinoma (ATC) and metastatic poorly differentiated thyroid carcinomas (PDTCs) are rare aggressive malignancies with poor overall survival…”
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Plasma steroid metabolome profiling for the diagnosis of adrenocortical carcinoma by Schweitzer, Sophie, Kunz, Meik, Kurlbaum, Max, Vey, Johannes, Kendl, Sabine, Deutschbein, Timo, Hahner, Stefanie, Fassnacht, Martin, Dandekar, Thomas, Kroiss, Matthias

“…Objective Current workup for the pre-operative distinction between frequent adrenocortical adenomas (ACAs) and rare but aggressive adrenocortical carcinomas…”
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A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus by Fenske, Wiebke, Refardt, Julie, Chifu, Irina, Schnyder, Ingeborg, Winzeler, Bettina, Drummond, Juliana, Ribeiro-Oliveira, Antônio, Drescher, Tilman, Bilz, Stefan, Vogt, Deborah R, Malzahn, Uwe, Kroiss, Matthias, Christ, Emanuel, Henzen, Christoph, Fischli, Stefan, Tönjes, Anke, Mueller, Beat, Schopohl, Jochen, Flitsch, Jörg, Brabant, Georg, Fassnacht, Martin, Christ-Crain, Mirjam

“…This study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor of arginine vasopressin, in patients with…”
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Integrated genomic characterization of adrenocortical carcinoma by Assié, Guillaume, Letouzé, Eric, Fassnacht, Martin, Jouinot, Anne, Luscap, Windy, Barreau, Olivia, Omeiri, Hanin, Rodriguez, Stéphanie, Perlemoine, Karine, René-Corail, Fernande, Elarouci, Nabila, Sbiera, Silviu, Kroiss, Matthias, Allolio, Bruno, Waldmann, Jens, Quinkler, Marcus, Mannelli, Massimo, Mantero, Franco, Papathomas, Thomas, De Krijger, Ronald, Tabarin, Antoine, Kerlan, Véronique, Baudin, Eric, Tissier, Frédérique, Dousset, Bertrand, Groussin, Lionel, Amar, Laurence, Clauser, Eric, Bertagna, Xavier, Ragazzon, Bruno, Beuschlein, Felix, Libé, Rossella, de Reyniès, Aurélien, Bertherat, Jérôme

“…Jérôme Bertherat, Aurélien de Reyniès and colleagues perform integrated genomic analyses of adrenocortical carcinomas. They discover recurrent alterations in…”
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The role of regulated necrosis in endocrine diseases by Tonnus, Wulf, Belavgeni, Alexia, Beuschlein, Felix, Eisenhofer, Graeme, Fassnacht, Martin, Kroiss, Matthias, Krone, Nils P., Reincke, Martin, Bornstein, Stefan R., Linkermann, Andreas

“…The death of endocrine cells is involved in type 1 diabetes mellitus, autoimmunity, adrenopause and hypogonadotropism. Insights from research on basic cell…”
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Major Prognostic Role of Ki67 in Localized Adrenocortical Carcinoma After Complete Resection by Beuschlein, Felix, Weigel, Jens, Saeger, Wolfgang, Kroiss, Matthias, Wild, Vanessa, Daffara, Fulvia, Libé, Rosella, Ardito, Arianna, Al Ghuzlan, Abir, Quinkler, Marcus, Oßwald, Andrea, Ronchi, Cristina L, de Krijger, Ronald, Feelders, Richard A, Waldmann, Jens, Willenberg, Holger S, Deutschbein, Timo, Stell, Anthony, Reincke, Martin, Papotti, Mauro, Baudin, Eric, Tissier, Frédérique, Haak, Harm R, Loli, Paola, Terzolo, Massimo, Allolio, Bruno, Müller, Hans-Helge, Fassnacht, Martin

“…Background: Recurrence of adrenocortical carcinoma (ACC) even after complete (R0) resection occurs frequently. Objective: The aim of this study was to identify…”
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Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study by Fassnacht, Martin, MD, Berruti, Alfredo, MD, Baudin, Eric, MD, Demeure, Michael J, MD, Gilbert, Jill, MD, Haak, Harm, MD, Kroiss, Matthias, MD, Quinn, David I, FRACP, Hesseltine, Elizabeth, MSN, Ronchi, Cristina L, MD, Terzolo, Massimo, MD, Choueiri, Toni K, MD, Poondru, Srinivasu, PhD, Fleege, Tanya, MS, Rorig, Ramona, Chen, Jihong, PhD, Stephens, Andrew W, MD, Worden, Francis, MD, Hammer, Gary D, Prof

“…Summary Background Adrenocortical carcinoma is a rare, aggressive cancer for which few treatment options are available. Linsitinib (OSI-906) is a potent, oral…”
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Inhibition of Cholesterol Esterification in the Adrenal Gland by ATR101/PD132301–2, A Promising Case of Drug Repurposing by Kroiss, Matthias, Fassnacht, Martin

“…Adrenocortical carcinoma (ACC) is a malignancy that harbors a significant risk of recurrence even after complete resection and has a particularly unfavorable…”
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SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma? by Löhr, Mario, Härtig, Wolfgang, Schulze, Almut, Kroiß, Matthias, Sbiera, Silviu, Lapa, Constantin, Mages, Bianca, Strobel, Sabrina, Hundt, Jennifer Elisabeth, Bohnert, Simone, Kircher, Stefan, Janaki-Raman, Sudha, Monoranu, Camelia-Maria

“…Targeting molecular alterations as an effective treatment for isocitrate dehydrogenase-wildtype glioblastoma (GBM) patients has not yet been established…”
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Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells by Sbiera, Silviu, Leich, Ellen, Liebisch, Gerhard, Sbiera, Iuliu, Schirbel, Andreas, Wiemer, Laura, Matysik, Silke, Eckhardt, Carolin, Gardill, Felix, Gehl, Annemarie, Kendl, Sabine, Weigand, Isabel, Bala, Margarita, Ronchi, Cristina L, Deutschbein, Timo, Schmitz, Gerd, Rosenwald, Andreas, Allolio, Bruno, Fassnacht, Martin, Kroiss, Matthias

“…Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in advanced stages. Mitotane is approved as an orphan drug for treatment of…”
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Clinical presentation, treatment and outcome of anaplastic thyroid carcinoma: results of a multicenter study in Germany by Wendler, Julia, Kroiss, Matthias, Gast, Katja, Kreissl, Michael C, Allelein, Stephanie, Lichtenauer, Urs, Blaser, Rainer, Spitzweg, Christine, Fassnacht, Martin, Schott, Matthias, Führer, Dagmar, Tiedje, Vera

“…Context Anaplastic thyroid carcinoma (ATC) is an orphan disease and confers a dismal prognosis. Standard treatment is not established. Objective The aim of…”
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Endocrine side effects of cancer immunotherapy by Kroiß, Matthias, Schilling, Bastian, Deutschbein, Timo

“…Immune checkpoint inhibitors (ICI) have become a cornerstone in the treatment of various human malignancies. Immune-related adverse events (irAE) are common…”
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Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatography-tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma by Peitzsch, Mirko, Prejbisz, Aleksander, Kroiß, Matthias, Beuschlein, Felix, Arlt, Wiebke, Januszewicz, Andrzej, Siegert, Gabriele, Eisenhofer, Graeme

“…Measurements of plasma normetanephrine (NMN) and metanephrine (MN) provide a sensitive test for diagnosis of phaeochromocytomas and paragangliomas (PPGLs), but…”
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Interplay between glucocorticoids and tumor-infiltrating lymphocytes on the prognosis of adrenocortical carcinoma by Landwehr, Laura-Sophie, Altieri, Barbara, Schreiner, Jochen, Sbiera, Iuliu, Weigand, Isabel, Kroiss, Matthias, Fassnacht, Martin, Sbiera, Silviu

“…Adrenocortical carcinoma (ACC) is a rare endocrine malignancy. Tumor-related glucocorticoid excess is present in ~60% of patients and associated with…”
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Active steroid hormone synthesis renders adrenocortical cells highly susceptible to type II ferroptosis induction by Weigand, Isabel, Schreiner, Jochen, Röhrig, Florian, Sun, Na, Landwehr, Laura-Sophie, Urlaub, Hanna, Kendl, Sabine, Kiseljak-Vassiliades, Katja, Wierman, Margaret E., Angeli, José Pedro Friedmann, Walch, Axel, Sbiera, Silviu, Fassnacht, Martin, Kroiss, Matthias

“…Conditions of impaired adrenal function and tissue destruction, such as in Addison’s disease, and treatment resistance of adrenocortical carcinoma (ACC)…”
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Gemcitabine-Based Chemotherapy in Adrenocortical Carcinoma: A Multicenter Study of Efficacy and Predictive Factors by Henning, Judith E K, Deutschbein, Timo, Altieri, Barbara, Steinhauer, Sonja, Kircher, Stefan, Sbiera, Silviu, Wild, Vanessa, Schlötelburg, Wiebke, Kroiss, Matthias, Perotti, Paola, Rosenwald, Andreas, Berruti, Alfredo, Fassnacht, Martin, Ronchi, Cristina L

“…Abstract Context Adrenocortical carcinoma (ACC) is rare and confers an unfavorable prognosis in advanced stages. Other than combination chemotherapy with…”
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Simulation-Based Interpretation of Therapeutically Monitored Cabozantinib Plasma Concentration in Advanced Adrenocortical Carcinoma with Hemodialysis by Zimmermann, Sebastian, Kurlbaum, Max, Mayer, Stefanie, Fassnacht, Martin, Kroiss, Matthias, Scherf-Clavel, Oliver

“…Adrenocortical carcinoma is an orphan but aggressive malignancy with limited treatment options. Cabozantinib (CAB), a tyrosine kinase inhibitor, has emerged as…”
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