Search Results - "KROHN, K. A"

[18F]FMISO and [18F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression by RAJENDRAN, J. G, WILSON, D. C, KROHN, K. A, CONRAD, E. U, PETERSON, L. M, BRUCKNER, J. D, RASEY, J. S, CHIN, L. K, HOFSTRAND, P. D, GRIERSON, J. R, EARY, J. F

“…Hypoxia imparts resistance to radiotherapy and chemotherapy and also promotes a variety of changes in tumor biology through inducible promoters. The purpose of…”
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Kinetic Quantitation of Cerebral PET-FDG Studies Without Concurrent Blood Sampling: Statistical Recovery of the Arterial Input Function by O'Sullivan, F., Kirrane, J., Muzi, M., O'Sullivan, J.N., Spence, A.M., Mankoff, D.A., Krohn, K.A.

“…Kinetic quantitation of dynamic positron emission tomography (PET) studies via compartmental modeling usually requires the time-course of the radio-tracer…”
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Hypoxia imaging-directed radiation treatment planning by Rajendran, J G, Hendrickson, K R G, Spence, A M, Muzi, M, Krohn, K A, Mankoff, D A

“…Increasing evidence supports the role of the tumor microenvironment in modulating cancer behavior. Tissue hypoxia, an important and common condition affecting…”
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Carbon-11-Thymidine and FDG to Measure Therapy Response by Shields, Anthony F, Mankoff, David A, Link, Jeanne M, Graham, Michael M, Eary, Janet F, Kozawa, Susie M, Zheng, Minna, Lewellen, Barbara, Lewellen, Thomas K, Grierson, John R, Krohn, Kenneth A

“…This study was performed to determine if PET imaging with 11C-thymidine could measure tumor response to chemotherapy early after the initiation of treatment…”
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Applications of PET imaging with the proliferation marker [18F]-FLT by Peck, M, Pollack, H A, Friesen, A, Muzi, M, Shoner, S C, Shankland, E G, Fink, J R, Armstrong, J O, Link, J M, Krohn, K A

“…[18F]-3'-fluoro-3'-deoxythymidine (FLT) is a nucleoside-analog imaging agent for quantifying cellular proliferation that was first reported in 1998. It…”
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[18F]Fluoroestradiol Radiation Dosimetry in Human PET Studies by Mankoff, David A, Peterson, Lanell M, Tewson, Timothy J, Link, Jeanne M, Gralow, Julie R, Graham, Michael M, Krohn, Kenneth A

“…[18F]16alpha-fluoroestradiol (FES) is a PET imaging agent useful for the study of estrogen receptors in breast cancer. We estimated the radiation dosimetry for…”
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2-[C-11]thymidine imaging of malignant brain tumors by EARY, J. F, MANKOFF, D. A, SPENCE, A. M, BERGER, M. S, OLSHEN, A, LINK, J. M, O'SULLIVAN, F, KROHN, K. A

“…Malignant brain tumors pose diagnostic and therapeutic problems. Despite the advent of new brain imaging modalities, including magnetic resonance imaging (MRI)…”
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Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography by Koh, W J, Bergman, K S, Rasey, J S, Peterson, L M, Evans, M L, Graham, M M, Grierson, J R, Lindsley, K L, Lewellen, T K, Krohn, K A

“…Recent clinical investigations have shown a strong correlation between pretreatment tumor hypoxia and poor response to radiotherapy. These observations raise…”
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Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole by Koh, W J, Rasey, J S, Evans, M L, Grierson, J R, Lewellen, T K, Graham, M M, Krohn, K A, Griffin, T W

“…Fluoromisonidazole (FMISO) has been shown to bind selectively to hypoxic cells in vitro and in vivo at radiobiologically significant oxygen levels. When…”
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Kinetic Analysis of 2-[Carbon-11]Thymidine PET Imaging Studies: Compartmental Model and Mathematical Analysis by Mankoff, David A, Shields, Anthony F, Graham, Michael M, Link, Jeanne M, Eary, Janet F, Krohn, Kenneth A

“…Carbon-11-thymidine is a PET tracer of DNA synthesis and cellular proliferation. Quantitative analysis of [11C]thymidine images is complicated by the presence…”
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Glucose metabolism in human malignant gliomas measured quantitatively with PET, 1-[C-11]glucose and FDG : Analysis of the FDG lumped constant by SPENCE, A. M, MUZI, M, OJEMANN, G. A, GRAHAM, M. M, O'SULLIVAN, F, KROHN, K. A, LINK, J. M, LEWELLEN, T. K, LEWELLEN, B, FREEMAN, S. D, BERGER, M. S

“…Calculation of the glucose metabolic rate (MRGlc) in brain with PET and 2-[18F]fluoro-2-deoxy-D-glucose (FDG) requires knowing the rate of uptake of FDG…”
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Kinetic Analysis of 2-[11C]Thymidine PET Imaging Studies: Validation Studies by Mankoff, David A, Shields, Anthony F, Link, Jeanne M, Graham, Michael M, Muzi, Mark, Peterson, Lanell M, Eary, Janet F, Krohn, Kenneth A

“…2-[11C]thymidine has been tested as a PET tracer of cellular proliferation. We have previously described a model of thymidine and labeled metabolite kinetics…”
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Treatment of refractory non-Hodgkin's lymphoma with radiolabeled MB-1 (anti-CD37) antibody by Press, O W, Eary, J F, Badger, C C, Martin, P J, Appelbaum, F R, Levy, R, Miller, R, Brown, S, Nelp, W B, Krohn, K A

“…The biodistribution, toxicity, and therapeutic potential of anti-CD37 monoclonal antibody (MoAb) MB-1 labeled with iodine 131 (131I) was evaluated in ten…”
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The physical chemistry of ligand-receptor binding identifies some limitations to the analysis of receptor images by Krohn, Kenneth A

“…The biophysical chemistry of ligand-receptor interactions imposes some restrictions on the characteristics of a radioligand if it is to be a useful tracer for…”
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Molecular imaging of regional brain tumor biology by Spence, A.M., Muzi, M., Krohn, K.A.

“…Energy metabolism measurements in gliomas in vivo are now performed widely with positron emission tomography (PET). This capability has developed from a large…”
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PET radiopharmaceuticals: state-of-the-art and future prospects by Tewson, Timothy J., Krohn, Kenneth A.

“…In this review we provide a conceptual overview of radiopharmaceuticals containing positron-emitting isotopes, not a catalog of radiopharmaceuticals or details…”
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Fluorine-18-Fluoromisonidazole Radiation Dosimetry in Imaging Studies by Graham, Michael M, Peterson, Lanell M, Link, Jeanne M, Evans, Margaret L, Rasey, Janet s, Koh, Wui-Jin, Caldwell, James H, Krohn, Kenneth A

“…Fluoromisonidazole (FMISO), labeled with the positron emitter 18F, is a useful hypoxia imaging agent for PET studies, with potential applications in patients…”
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Positron emission tomography: imaging tumor response by Eary, J F, Krohn, K A

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Analysis of 2-Carbon-11-Thymidine Blood Metabolites in PET Imaging by Shields, Anthony F, Graham, Michael M, Zheng, Minna, Kozawa, Susan M, Link, Jeanne M, Krohn, Kenneth A

“…Carbon-11-thymidine labeled in the ring-2 position was used with PET to image tumor and tissue proliferation. Since thymidine is rapidly degraded in the body,…”
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Imaging and Treatment of B-Cell Lymphoma by Eary, Janet F, Press, Oliver W, Badger, Christopher C, Durack, Lawrence D, Richter, Karen Y, Addison, Stanley J, Krohn, Kenneth A, Fisher, Darrell R, Porter, Bruce A, Williams, David L, Martin, Paul J, Appelbaum, Frederick R, Levy, Ronald, Brown, Sherri L, Miller, Richard A, Nelp, Wil B, Bernstein, Irwin D

“…Ten patients with non-Hodgkin's lymphoma have been evaluated as candidates for experimental radioimmunotherapy and five of those patients have been treated…”
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