Search Results - "KRIZ, Vitezslav"

Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases by Kasparek, Petr, Krausova, Michaela, Haneckova, Radka, Kriz, Vitezslav, Zbodakova, Olga, Korinek, Vladimir, Sedlacek, Radislav

“…•New TALE nucleases for efficient targeting of the Rosa26 locus were generated and are freely available to community.•The targeting strategy does not exhibit…”
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A Complex Role for FGF‐2 in Self‐Renewal, Survival, and Adhesion of Human Embryonic Stem Cells by Eiselleova, Livia, Matulka, Kamil, Kriz, Vitezslav, Kunova, Michaela, Schmidtova, Zuzana, Neradil, Jakub, Tichy, Boris, Dvorakova, Dana, Pospisilova, Sarka, Hampl, Ales, Dvorak, Petr

“…The transcription program that is responsible for the pluripotency of human ESCs (hESCs) is believed to be comaintained by exogenous fibroblast growth factor‐2…”
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TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and Invasiveness by Švec, Jiří, Šťastná, Monika, Janečková, Lucie, Hrčkulák, Dušan, Vojtěchová, Martina, Onhajzer, Jakub, Kříž, Vítězslav, Galušková, Kateřina, Šloncová, Eva, Kubovčiak, Jan, Pfeiferová, Lucie, Hrudka, Jan, Matěj, Radoslav, Waldauf, Petr, Havlůj, Lukáš, Kolář, Michal, Kořínek, Vladimír

“…Trophoblastic cell surface antigen 2 (TROP2) is a membrane glycoprotein overexpressed in many solid tumors with a poor prognosis, including intestinal…”
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Structural and Functional Characterization of the Wnt Inhibitor APC Membrane Recruitment 1 (Amer1) by Tanneberger, Kristina, Pfister, Astrid S., Kriz, Vitezslav, Bryja, Vitezslav, Schambony, Alexandra, Behrens, Jürgen

“…Amer1/WTX binds to the tumor suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing β-catenin degradation. We show here…”
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Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells by Kriz, Vitezslav, Korinek, Vladimir

“…In this review, we address aspects of Wnt, R-Spondin (RSPO) and Hippo signalling, in both healthy and transformed intestinal epithelium. In intestinal stem…”
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Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells by Gustafsson, Karin, Calounova, Gabriela, Hjelm, Fredrik, Kriz, Vitezslav, Heyman, Birgitta, Grönvik, Kjell-Olov, Mostoslavsky, Gustavo, Welsh, Michael

“…Shb, a ubiquitously expressed Src homology 2 domain-containing adaptor protein has previously been implicated in the signaling of various tyrosine kinase…”
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The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation by Annerén, Cecilia, Lindholm, Cecilia K, Kriz, Vitezslav, Welsh, Michael

“…Recent experiments have unravelled novel signal transduction pathways that involve the SRC homology 2 (SH2) domain adapter protein SHB. SHB is ubiquitously…”
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The SHB Adapter Protein Is Required for Normal Maturation of Mesoderm during in Vitro Differentiation of Embryonic Stem Cells by Kriz, Vitezslav, Ågren, Nina, Lindholm, Cecilia K., Lenell, Samuel, Saldeen, Johan, Mares, Jaroslav, Welsh, Michael

“…Definitive mesoderm arises from a bipotent mesendodermal population, and to study processes controlling its development at this stage, embryonic stem (ES)…”
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Human Colorectal Cancer from the Perspective of Mouse Models by Stastna, Monika, Janeckova, Lucie, Hrckulak, Dusan, Kriz, Vitezslav, Korinek, Vladimir

“…Colorectal cancer (CRC) is a heterogeneous disease that includes both hereditary and sporadic types of tumors. Tumor initiation and growth is driven by…”
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The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors by He, Qi, Li, Xiujuan, Singh, Kailash, Luo, Zhengkang, Meija-Cordova, Mariela, Jamalpour, Maria, Lindahl, Björn, Kriz, Vitezslav, Vuolteenaho, Reetta, Ulvmar, Maria, Welsh, Michael

“…The tamoxifen-responsive conditional Cdh5-CreERT2 is commonly used for endothelial cell specific conditional deletion of loxP-flanked gene sequences. To…”
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Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice by Tumova, Lucie, Pombinho, Antonio R, Vojtechova, Martina, Stancikova, Jitka, Gradl, Dietmar, Krausova, Michaela, Sloncova, Eva, Horazna, Monika, Kriz, Vitezslav, Machonova, Olga, Jindrich, Jindrich, Zdrahal, Zbynek, Bartunek, Petr, Korinek, Vladimir

“…The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the…”
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Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells by Hrckulak, Dusan, Janeckova, Lucie, Lanikova, Lucie, Kriz, Vitezslav, Horazna, Monika, Babosova, Olga, Vojtechova, Martina, Galuskova, Katerina, Sloncova, Eva, Korinek, Vladimir

“…T-cell factor 4 (TCF4), together with β-catenin coactivator, functions as the major transcriptional mediator of the canonical wingless/integrated (Wnt)…”
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Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse by Kriz, Vitezslav, Krausova, Michaela, Buresova, Petra, Dobes, Jan, Hrckulak, Dusan, Babosova, Olga, Svec, Jiri, Korinek, Vladimir

“…Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4) is produced in a broad spectrum of mouse embryonic and adult tissues and its deficiency…”
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Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation by Tanneberger, Kristina, Pfister, Astrid S, Brauburger, Katharina, Schneikert, Jean, Hadjihannas, Michel V, Kriz, Vitezslav, Schulte, Gunnar, Bryja, Vitezslav, Behrens, Jürgen

“…Phosphorylation of the Wnt receptor low‐density lipoprotein receptor‐related protein 6 (LRP6) by glycogen synthase kinase 3β (GSK3β) and casein kinase 1γ…”
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Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB by Pietilä, Ilkka, Van Mourik, Djenolan, Tamelander, Andreas, Kriz, Vitezslav, Claesson-Welsh, Lena, Tengholm, Anders, Welsh, Michael

“…Focal adhesion kinase (FAK) is essential for vascular endothelial growth factor-A (VEGFA)/VEGF receptor-2 (VEGFR2)-stimulated angiogenesis and vascular…”
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Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P 2 to LRP6 phosphorylation: Amer1 regulates LRP6 phosphorylation by Tanneberger, Kristina, Pfister, Astrid S, Brauburger, Katharina, Schneikert, Jean, Hadjihannas, Michel V, Kriz, Vitezslav, Schulte, Gunnar, Bryja, Vitezslav, Behrens, Jürgen

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Role of LGR5-positive mesenchymal cells in craniofacial development by Olbertová, Kristýna, Hrčkulák, Dušan, Kříž, Vítězslav, Jesionek, Wojciech, Kubovčiak, Jan, Ešner, Milan, Kořínek, Vladimír, Buchtová, Marcela

“…Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5), a Wnt pathway member, has been previously recognised as a stem cell marker in numerous…”
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Dysfunctional Microvasculature as a Consequence of Shb Gene Inactivation Causes Impaired Tumor Growth by FUNA, Nina S, KRIZ, Vitezslav, GUANGXIANG ZANG, CALOUNOVA, Gabriela, AKERBLOM, Bjöm, MARES, Jaroslav, LARSSON, Erik, YING SUN, BETSHOLTZ, Christer, WELSH, Michael

“…Shb (Src homology 2 protein B) is an adapter protein downstream of the vascular endothelial growth factor receptor receptor-2 (VEGFR-2). Previous experiments…”
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β-Arrestin Promotes Wnt-induced Low Density Lipoprotein Receptor-related Protein 6 (Lrp6) Phosphorylation via Increased Membrane Recruitment of Amer1 Protein by Kříž, Vítězslav, Pospíchalová, Vendula, Mašek, Jan, Kilander, Michaela Brita Christina, Slavík, Josef, Tanneberger, Kristina, Schulte, Gunnar, Machala, Miroslav, Kozubík, Alois, Behrens, Juergen, Bryja, Vítězslav

“…β-Arrestin is a scaffold protein that regulates signal transduction by seven transmembrane-spanning receptors. Among other functions it is also critically…”
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IRESite: the database of experimentally verified IRES structures (www.iresite.org) by Mokrejs, Martin, Vopálenský, Václav, Kolenaty, Ondrej, Masek, Tomás, Feketová, Zuzana, Sekyrová, Petra, Skaloudová, Barbora, Kríz, Vítezslav, Pospísek, Martin

“…IRESite is an exhaustive, manually annotated non-redundant relational database focused on the IRES elements (Internal Ribosome Entry Site) and containing…”
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