Search Results - "KRIPALANI, K. J."

Biotransformation of Irbesartan in Man by CHANDO, T. J, EVERETT, D. W, KAHLE, A. D, STARRETT, A. M, VACHHARAJANI, N, WEN CHYI SHYU, KRIPALANI, K. J, BARBHAIYA, R. H

“…The metabolism of irbesartan, a highly selective and potent nonpeptide angiotensin II receptor antagonist, has been investigated in humans. An aliquot of…”
Get full text

Distribution of the dipeptide transporter system along the gastrointestinal tract of rats based on absorption of a stable and specific probe, SQ-29852 by Marino, A M, Chong, S, Dando, S A, Kripalani, K J, Bathala, M S, Morrison, R A

“…Peptidic drugs such as beta-lactam aminocephalosporin antibiotics (e.g., cephalexin) and the ACE inhibitors lisinopril, quinapril, and benzazepril are…”
Get more information

Pharmacokinetics of fosinopril in patients with various degrees of renal function by Hui, K K, Duchin, K L, Kripalani, K J, Chan, D, Kramer, P K, Yanagawa, N

“…Single-dose kinetics of fosinopril, a new phosphorus-containing angiotensin-converting enzyme inhibitor and its active diacid, fosinoprilat, were investigated…”
Get more information

INTESTINAL ABSORPTION OF CAPTOPRIL AND TWO THIOESTER ANALOGS IN RATS AND DOGS by MORRISON, R. A., KRIPALANI, K. J., MARINO, A. M., DEAN, A. V., MIGDALOF, B. H., WEINSTEIN, S. H., JAIN, N. B., BATHALA, M. S., SINGHVI, S. M.

“…The objectives of this study were (i) to determine whether the reduced absorption of captopril from the colon of humans also occurs in rats and (ii), after…”
Get full text

Percutaneous absorption of [3H]tretinoin and systemic exposure to mequinol after dermal application of 2% mequinol/0.01% [3H]tretinoin (Solagé®) solution in healthy volunteers by Everett, Donald W., Franz, Thomas J., Chando, Theodore J., Gale, P. Jane, Lehman, Paul A., Schwarzel, Edmund H., Parab, Prakash V., D'Arienzo, Celia J., Kripalani, Kishin J.

“…Solagé® is a combination product composed of 2% mequinol (4‐hydroxyanisole) and 0.01% tretinoin (all‐trans‐retinoic acid) in an ethanolic solution, which is…”
Get full text

Disposition of [14C]aztreonam in rats, dogs, and monkeys by KRIPALANI, K. J, SINGHVI, S. M, WALKER, B. D, MIGDALOF, B. H, WEINSTEIN, S. H, EVERETT, D. W, BATHALA, M. S, DEAN, A. V, ITA, C. E, LAWRENCE, L, MEEKER, F. S. JR, SHAW, J. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Inversion of optical configuration of alpha-methylfluorene-2-acetic acid (cicloprofen) in rats and monkeys by Lan, S J, Kripalani, K J, Dean, A V, Egli, P, Difazio, L T, Schreiber, E C

“…A simple and sensitive radiometric method to determine the individual enantiomers of cicloprofen has been developed. 14C-Cicloprofen was converted to its…”
Get more information

Metabolism of captopril-L-cysteine, a captopril metabolite, in rats and dogs by Kripalani, K J, Dean, A V, Migdalof, B H

“…The metabolism of [14C]captopril-L-cysteine was studied in spontaneously hypertensive rats and pure-bred beagles after a single i.v. dose (4 mg/kg). During the…”
Get more information

Metabolism of triamcinolone acetonide-21-phosphate in dogs, monkeys, and rats by Kripalani, K J, Cohen, A I, Weliky, I, Schreiber, E C

“…The absorption, distribution and metabolic fate of triamcinolone acetonide-14C-21-phosphate were studied in the dog, monkey, and rat. A comparison of levels of…”
Get more information

Biotransformation in the monkey of cartazolate (SQ 65,396), a substituted pyrazolopyridine having anxiolytic activity by Kripalani, K J, Dreyfuss, J, Nemec, J, Cohen, A I, Meeker, F, Egli, P

“…1. The metabolism of cartazolate (SQ 65,396), an anxiolytic agent, was studied in four male rhesus monkeys after oral administration. 2. Seven metabolites were…”
Get more information

Absorption and bioavailability of captopril in mice and rats after administration by gavage and in the diet by Singhvi, S M, Kripalani, K J, Dean, A V, Keim, G R, Kulesza, J S, Meeker, Jr, F S, Ross, Jr, J J, Shaw, J M, Migdalof, B H

“…The absorption of captopril (I), a new antihypertensive agent, was studied in mice and rats at doses (50 and 1350 mg/kg) administered in the diet in chronic…”
Get more information

Metabolism of alpha-methylfluorene-2-acetic acid (cicloprofen): isolation and identification of metabolites from rat urine by Lan, S J, Dean, A V, Kripalani, K J, Cohen, A I

“…1. Four metabolites of alpha-methylfluorene-2-acetic acid (cicloprofen) have been isolated from rat urine and identified as the 7-hydroxy, 9-hydroxy,…”
Get more information

Binding of cortisol and its degradation products by human serum albumin by Kripalani, K J, Sorby, D L

Get more information

Stereospecific inversion of l-alpha-methylfluorene-2-acetic acid to its d-enantiomer in the dog by Kripalani, K J, El-Abdin, A Z, Dean, A V, Schreiber, E C

“…1. After administration of dl-alpha-methylfluorene-2-acetic acid to dogs, the optical rotation of the drug in blood increased with time. Of the total drug in…”
Get more information

Tetrahydrotriamcinolone and Triamcinolone: I. Ocular Penetration by SUGAR, JOEL, BURDE, RONALD M, SUGAR, ALAN, WALTMAN, STEPHEN R, KRIPALANI, K. J, WELIKY, IRVING, BECKER, BERNARD

Get full text

Studies on the mechanism of estrogen biosynthesis. VI. The stereochemistry of hydrogen elimination at C-2 during aromatization by Brodie, H J, Kripalani, K J, Possanza, G

Get full text

Disposition of captopril in normal subjects by Kripalani, K J, McKinstry, D N, Singhvi, S M, Willard, D A, Vukovich, R A, Migdalof, B H

“…The disposition of captopril, an angiotensin-converting enzyme inhibitor with antihypertensive properties, was studied in 10 normal male subjects after a…”
Get more information

Captopril: pharmacology, metabolism and disposition by Migdalof, B H, Antonaccio, M J, McKinstry, D N, Singhvi, S M, Lan, S J, Egli, P, Kripalani, K J

“…By inhibiting ACE, captopril blocks the conversion of AI or AII and augments the effects of bradykinin both in vitro and in vivo. In rats, dogs, and monkeys…”
Get more information

Metabolism of the (+)-, (+/-)-, and (-)-enantiomers of alpha-methylfluorene-2-acetic acid (cicloprofen) in rats by Dean, A V, Lan, S J, Kripalani, K J, Difazio, L T, Schreiber, E C

“…1. After oral or intraperitoneal administration of (+/-)-[14C]cicloprofen to rats, the peak plasma concentrations of radioactivity and the areas under the…”
Get more information