Search Results - "KRIEM, Badreddine"
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Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway
Published in Neurobiology of disease (01-07-2006)“…Recent data have revealed that soluble oligomeric amyloid-beta peptide (Abeta) may be the proximate effectors of neuronal injuries and death in Alzheimer's…”
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Up-regulation of hepatic lipolysis stimulated lipoprotein receptor by leptin: a potential lever for controlling lipid clearance during the postprandial phase
Published in The FASEB journal (01-11-2010)“…As a hepatic receptor for triglyceride-rich lipoproteins, the lipolysis-stimulated lipoprotein receptor (LSR) may be involved in the dynamics of lipid…”
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Towards a nutritional approach for prevention of Alzheimer's disease: Biochemical and cellular aspects
Published in Journal of the neurological sciences (15-11-2007)“…Abstract Alzheimer's disease (AD) is a major public health concern in all countries. Although the precise cause of AD is still unknown, a growing body of…”
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4
Sigmoidal compression rate-dependence of inert gas narcotic potency in rats: implication for lipid vs. protein theories of inert gas action in the central nervous system
Published in Brain research (19-10-1998)“…Inert gases at raised pressure exert anaesthetic effects. It is assumed that anaesthesia by the inert gases is fundamentally similar to anaesthesia produced by…”
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Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease
Published in The Journal of neuroscience (02-06-2010)“…The development of novel therapeutic strategies for Alzheimer's disease (AD) represents one of the biggest unmet medical needs today. Application of…”
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6
Administration of the glutamate uptake inhibitor l- trans-PDC in the globus pallidus and the substantia nigra, but not in the striatum, attenuates the psychostimulant effect of high helium pressure on locomotor activity in the rat
Published in Neuroscience research (30-12-1999)“…High helium pressure of more than 2 MPa produces central neuroexcitatory motor behavior. In rodents, symptoms comprise locomotor and motor activity (LMA),…”
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7
Does calculating impair postural stabilization allowed by visual cues?
Published in Experimental brain research (01-07-2014)“…In many daily situations, balance control is associated with a cognitive activity such as reading or a simple calculation. The objective of this study was to…”
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Role of 5-HT1b receptor in the pressure-induced behavioral and neurochemical disorders in rats
Published in Pharmacology, biochemistry and behavior (01-02-1996)“…When human divers and experimental animals are exposed to increasing environmental pressure, they develop the high-pressure neurologic syndrome (HPNS) that has…”
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N-truncated amyloid-β oligomers induce learning impairment and neuronal apoptosis
Published in Neurobiology of aging (01-09-2008)“…Abstract N-terminal-truncated forms of amyloid-β (Aβ) peptide have been recently suggested to play a pivotal role early in Alzheimer's disease (AD). Among…”
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Critical role of cPLA2 in Aβ oligomer-induced neurodegeneration and memory deficit
Published in Neurobiology of aging (01-06-2012)“…Abstract Soluble beta-amyloid (Aβ) oligomers are considered to putatively play a critical role in the early synapse loss and cognitive impairment observed in…”
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11
Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid‐β oligomers
Published in Journal of neurochemistry (01-01-2006)“…A growing body of evidence supports the notion that soluble oligomers of amyloid‐β (Aβ) peptide interact with the neuronal plasma membrane, leading to cell…”
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12
Microtubule-associated protein MAP1A, MAP1B, and MAP2 proteolysis during soluble amyloid beta-peptide-induced neuronal apoptosis. Synergistic involvement of calpain and caspase-3
Published in The Journal of biological chemistry (06-01-2006)“…A growing body of evidence supports the notion that soluble oligomeric forms of the amyloid beta-peptide (Abeta) may be the proximate effectors of neuronal…”
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13
Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid‐β peptide
Published in The FASEB journal (01-01-2005)“…ABSTRACT Recent data have revealed that soluble oligomeric forms of amyloid peptide (Aβ) may be the proximate effectors of the neuronal injury and death…”
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14
The essential role of lipids in Alzheimer's disease
Published in Biochimie (01-06-2009)“…In the absence of efficient diagnostic and therapeutic tools, Alzheimer's disease (AD) is a major public health concern due to longer life expectancy in the…”
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15
Membrane cholesterol interferes with neuronal apoptosis induced by soluble oligomers but not fibrils of the amyloid‐β peptide
Published in The FASEB journal (01-05-2004)“…ABSTRACT Neuronal cell death in Alzheimer's disease (AD) is partly induced by the interaction of the amyloid‐β peptide (Aβ) with the plasma membrane of target…”
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Humanin rescues cortical neurons from prion-peptide-induced apoptosis
Published in Molecular and cellular neuroscience (01-01-2004)“…We recently demonstrated that a soluble oligomeric prion peptide, the putative 118–135 transmembrane domain of prion protein (PrP), exhibited membrane…”
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Gamma-Aminobutyric Acid Neuropharmacological Investigations on Narcosis Produced by Nitrogen, Argon, or Nitrous Oxide
Published in Anesthesia and analgesia (01-03-2003)“…Inhaled anesthetics, including the gaseous anesthetics nitrous oxide and xenon, are thought to act by interacting directly with ion-channel receptors. In…”
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P2‐239: Cell‐based ciliary neurotrophic factor therapy against Alzheimer's disease
Published in Alzheimer's & dementia (01-07-2009)Get full text
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Cell-based ciliary neurotrophic factor therapy against Alzheimer's disease
Published in Alzheimer's & dementia (01-07-2009)Get full text
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O4‐02‐07: Cytosolic PLA2 is involved in the early synaptic alterations induced by the amyloid‐beta oligomers
Published in Alzheimer's & dementia (01-07-2009)Get full text
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