Search Results - "KRIEGER, Sigurd"
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ECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS
Published in International journal of molecular sciences (18-03-2020)“…The glomerular basement membrane (GBM) and extra-cellular matrix (ECM) are essential to maintain a functional interaction between the glomerular podocytes and…”
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Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro
Published in Frontiers in pharmacology (14-03-2018)“…Flavonoids, present in fruits, vegetables and traditional medicinal plants, show anticancer effects in experimental systems and are reportedly non-toxic. This…”
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Pursuing the Diffraction Limit with Nano-LED Scanning Transmission Optical Microscopy
Published in Sensors (Basel, Switzerland) (11-05-2021)“…Recent research into miniaturized illumination sources has prompted the development of alternative microscopy techniques. Although they are still being…”
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Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro
Published in Oncology reports (01-11-2016)“…Since cancer cells, when grown as spheroids, display drug sensitivity and radiation resistance patterns such as seen in vivo we recently established a…”
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Alterations in Fatty Acid Utilization and an Impaired Antioxidant Defense Mechanism Are Early Events in Podocyte Injury
Published in The American journal of pathology (2009)“…Ultrastructural alterations of podocytes are closely associated with loss of glomerular filtration function. In the present study, we explored changes at the…”
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Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells
Published in BMC molecular biology (07-03-2007)“…Podoplanin is a membrane mucin that, among a series of tissues, is expressed on late osteoblasts and osteocytes. Since recent findings have focussed on…”
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Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma
Published in Human pathology (2005)“…Distinguishing renal oncocytoma from chromophobe and other renal carcinomas is essential, considering their differing biological potentials. Although renal…”
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Mapping of conformational IgE epitopes on Phl p 5a by using mimotopes from a phage display library
Published in Journal of Allergy and Clinical Immunology (01-12-2004)“…Phl p 5 represents a major allergen of timothy grass pollen (Phleum pratense). Detailed knowledge about the structures responsible for IgE binding would allow…”
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Lymphatic Precollectors Contain a Novel, Specialized Subpopulation of Podoplaninlow , CCL27-Expressing Lymphatic Endothelial Cells
Published in The American journal of pathology (01-10-2008)“…Expression of the lymphoendothelial marker membrane mucoprotein podoplanin (podo) distinguishes endothelial cells of both blood and lymphatic lineages. We have…”
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IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA
Published in Nature immunology (01-07-2011)“…The antiviral protein IFIT1 is upregulated substantially in the cytoplasm of virus-infected cells. Superti-Furga and colleagues show that IFIT1 is part of a…”
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Defects in microvillus crosslinking sensitize to colitis and inflammatory bowel disease
Published in EMBO reports (09-10-2023)“…Intestinal epithelial cells are covered by the brush border, which consists of densely packed microvilli. The Intermicrovillar Adhesion Complex (IMAC) links…”
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Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching
Published in British journal of cancer (26-07-2016)“…Background: The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC)…”
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Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro
Published in Human molecular genetics (01-07-2015)“…Invasive colorectal cancer is associated with poor prognosis requiring treatment with systemic chemotherapies usually including 5-fluorouracil. A consequence…”
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Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling
Published in Cellular and molecular life sciences : CMLS (01-05-2017)“…Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances…”
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AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis
Published in Human molecular genetics (15-11-2016)“…A causal link between overexpression of aryl hydrocarbon receptor (AHR) and its target cytochrome P450 1A1 (CYP1A1) and metastatic outgrowth of various cancer…”
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Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse
Published in The Journal of clinical investigation (01-05-2011)“…In individuals with mammary carcinoma, the most relevant prognostic predictor of distant organ metastasis and clinical outcome is the status of axillary lymph…”
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Published in International journal of oncology (01-07-2018)“…Metastasising breast cancer cells communicate with adjacent lymph endothelia, intravasate and disseminate through lymphatic routes, colonise lymph nodes and…”
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12(S)-HETE induces lymph endothelial cell retraction in�vitro by upregulation of SOX18
Published in International journal of oncology (26-04-2018)Get full text
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Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro
Published in Food and chemical toxicology (01-01-2018)“…Mechanisms how colorectal cancer (CRC) cells penetrate blood micro-vessel endothelia and metastasise is poorly understood. To study blood endothelial cell…”
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