Search Results - "KREIPE, Hans"

Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group by Nielsen, Torsten O, Leung, Samuel C. Y, Rimm, David L, Dodson, Andrew, Acs, Balazs, Badve, Sunil, Denkert, Carsten, Ellis, Matthew J, Fineberg, Susan, Flowers, Margaret, Kreipe, Hans H, Laenkholm, Anne-Vibeke, Pan, Hongchao, Penault-Llorca, Frédérique M, Polley, Mei-Yin, Salgado, Roberto, Smith, Ian E, Sugie, Tomoharu, Bartlett, John M. S, McShane, Lisa M, Dowsett, Mitch, Hayes, Daniel F

“…Abstract Ki67 immunohistochemistry (IHC), commonly used as a proliferation marker in breast cancer, has limited value for treatment decisions due to…”
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Cytogenetics and genomics in CML and other myeloproliferative neoplasms by Kreipe, Hans H., Schlegelberger, Brigitte

“…Chronic myeloid leukemia is defined by the presence of the Philadelphia translocation t (9; 22) resulting in the BCR::ABL1 fusion. The other myeloproliferative…”
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Transcription factor AP‐2beta in development, differentiation and tumorigenesis by Raap, Mieke, Gierendt, Lisa, Kreipe, Hans H., Christgen, Matthias

“…To date, the AP‐2 family of transcription factors comprises five members. Transcription factor AP‐2beta (TFAP2B)/AP‐2β was first described in 1995. Several…”
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A multicentre analytical comparison study of inter‐reader and inter‐assay agreement of four programmed death‐ligand 1 immunohistochemistry assays for scoring in triple‐negative breast cancer by Noske, Aurelia, Ammann, Johannes U, Wagner, Daniel‐Christoph, Denkert, Carsten, Lebeau, Annette, Sinn, Peter, Kreipe, Hans‐Heinrich, Sommer, Ulrich, Baretton, Gustavo, Steiger, Katja, Kiechle, Marion, Hieke‐Schulz, Stefanie, Flores, Mike, Roth, Wilfried, Weichert, Wilko

“…Aims Studies in various cancer types have demonstrated discordance between results from different programmed death‐ligand 1 (PD‐L1) assays. Here, we compare…”
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Sensitive and reliable detection of KIT p.D816V mutation in decalcified archival bone marrow trephines by Odensass, Miriam, Bartels, Stephan, Schlue, Jerome, Büsche, Guntram, Kreipe, Hans H., Lehmann, Ulrich

“…Abstract The majority of mastocytosis cases are characterized by an activating mutation in the KIT gene in codon 816. The detection of this alteration is of…”
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West German Study Group Phase III PlanB Trial: First Prospective Outcome Data for the 21-Gene Recurrence Score Assay and Concordance of Prognostic Markers by Central and Local Pathology Assessment by Gluz, Oleg, Nitz, Ulrike A, Christgen, Matthias, Kates, Ronald E, Shak, Steven, Clemens, Michael, Kraemer, Stefan, Aktas, Bahriye, Kuemmel, Sherko, Reimer, Toralf, Kusche, Manfred, Heyl, Volker, Lorenz-Salehi, Fatemeh, Just, Marianne, Hofmann, Daniel, Degenhardt, Tom, Liedtke, Cornelia, Svedman, Christer, Wuerstlein, Rachel, Kreipe, Hans H, Harbeck, Nadia

“…The 21-gene Recurrence Score (RS) assay is a validated prognostic/predictive tool in early hormone receptor-positive breast cancer (BC); however, only a few…”
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Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group by Denkert, Carsten, Wienert, Stephan, Poterie, Audrey, Loibl, Sibylle, Budczies, Jan, Badve, Sunil, Bago-Horvath, Zsuzsanna, Bane, Anita, Bedri, Shahinaz, Brock, Jane, Chmielik, Ewa, Christgen, Matthias, Colpaert, Cecile, Demaria, Sandra, Van den Eynden, Gert, Floris, Giuseppe, Fox, Stephen B, Gao, Dongxia, Ingold Heppner, Barbara, Kim, S Rim, Kos, Zuzana, Kreipe, Hans H, Lakhani, Sunil R, Penault-Llorca, Frederique, Pruneri, Giancarlo, Radosevic-Robin, Nina, Rimm, David L, Schnitt, Stuart J, Sinn, Bruno V, Sinn, Peter, Sirtaine, Nicolas, O'Toole, Sandra A, Viale, Giuseppe, Van de Vijver, Koen, de Wind, Roland, von Minckwitz, Gunter, Klauschen, Frederick, Untch, Michael, Fasching, Peter A, Reimer, Toralf, Willard-Gallo, Karen, Michiels, Stefan, Loi, Sherene, Salgado, Roberto

“…Multiple independent studies have shown that tumor-infiltrating lymphocytes (TIL) are prognostic in breast cancer with potential relevance for response to…”
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A Brief Overview of the WHO Classification of Breast Tumors, 4th Edition, Focusing on Issues and Updates from the 3rd Edition by Sinn, Hans-Peter, Kreipe, Hans

“…The WHO Classification of Tumors of the Breast, 4th edition, is an update to the 3rd edition that was published in 2003, and covers all neoplastic and…”
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Endocrine Therapy Response and 21-Gene Expression Assay for Therapy Guidance in HR+/HER2– Early Breast Cancer by Nitz, Ulrike A., Gluz, Oleg, Kümmel, Sherko, Christgen, Matthias, Braun, Michael, Aktas, Bahriye, Lüdtke-Heckenkamp, Kerstin, Forstbauer, Helmut, Grischke, Eva-Maria, Schumacher, Claudia, Darsow, Maren, Krauss, Katja, Nuding, Benno, Thill, Marc, Potenberg, Jochem, Uleer, Christoph, Warm, Mathias, Fischer, Hans Holger, Malter, Wolfram, Hauptmann, Michael, Kates, Ronald E., Gräser, Monika, Würstlein, Rachel, Shak, Steven, Baehner, Frederick, Kreipe, Hans H., Harbeck, Nadia

“…PURPOSE To our knowledge, WSG-ADAPT-HR+/HER2– (ClinicalTrials.gov identifier: NCT01779206 ; n = 5,625 registered) is the first trial combining the 21-gene…”
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Clinical validity and clinical utility of Ki67 in early breast cancer by Kreipe, Hans, Harbeck, Nadia, Christgen, Matthias

“…Ki67 represents an immunohistochemical nuclear localized marker that is widely used in surgical pathology. Nuclear immunoreactivity for Ki67 indicates that…”
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Reducing chemotherapy use in clinically high-risk, genomically low-risk pN0 and pN1 early breast cancer patients: five-year data from the prospective, randomised phase 3 West German Study Group (WSG) PlanB trial by Nitz, Ulrike, Gluz, Oleg, Christgen, Matthias, Kates, Ronald E., Clemens, Michael, Malter, Wolfram, Nuding, Benno, Aktas, Bahriye, Kuemmel, Sherko, Reimer, Toralf, Stefek, Andrea, Lorenz-Salehi, Fatemeh, Krabisch, Petra, Just, Marianne, Augustin, Doris, Liedtke, Cornelia, Chao, Calvin, Shak, Steven, Wuerstlein, Rachel, Kreipe, Hans H., Harbeck, Nadia

“…Background The prospective phase 3 PlanB trial used the Oncotype DX ® Recurrence Score ® (RS) to define a genomically low-risk subset of clinically high-risk…”
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Clinically latent and autopsy-verified inflammatory disorders and malignant tumours in transplant patients by Mund, Elias, Salem, Johannes, Kreipe, Hans H, Hussein, Kais

“…The number of clinical autopsies decreases while the rate of missed relevant diagnoses is known to be 2%-20%. In this study, we focused on postmortem…”
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The phenotype of human STK4 deficiency by Abdollahpour, Hengameh, Appaswamy, Giridharan, Kotlarz, Daniel, Diestelhorst, Jana, Beier, Rita, Schäffer, Alejandro A., Gertz, E. Michael, Schambach, Axel, Kreipe, Hans H., Pfeifer, Dietmar, Engelhardt, Karin R., Rezaei, Nima, Grimbacher, Bodo, Lohrmann, Sabine, Sherkat, Roya, Klein, Christoph

“…We describe a novel clinical phenotype associating T- and B-cell lymphopenia, intermittent neutropenia, and atrial septal defects in 3 members of a…”
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Identification of differentially expressed microRNAs in human male breast cancer by Lehmann, Ulrich, Streichert, Thomas, Otto, Benjamin, Albat, Cord, Hasemeier, Britta, Christgen, Henriette, Schipper, Elisa, Hille, Ursula, Kreipe, Hans H, Länger, Florian

“…The discovery of small non-coding RNAs and the subsequent analysis of microRNA expression patterns in human cancer specimens have provided completely new…”
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Treatment-related hemophagocytic lymphohistiocytosis secondary to checkpoint inhibition with nivolumab plus ipilimumab by Satzger, Imke, Ivanyi, Philipp, Länger, Florian, Kreipe, Hans-Heinrich, Schaper-Gerhardt, Katrin, Beutel, Gernot, Cornberg, Markus, Gutzmer, Ralf

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Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial by Suttorp, Meinolf, Schulze, Philipp, Glauche, Ingmar, Göhring, Gudrun, von Neuhoff, Nils, Metzler, Markus, Sedlacek, Petr, de Bont, Eveline S. J. M., Balduzzi, Adriana, Lausen, Birgitte, Aleinikova, Olga, Sufliarska, Sabina, Henze, Günter, Strauss, Gabriele, Eggert, Angelika, Kremens, Bernhard, Groll, Andreas H., Berthold, Frank, Klein, Christoph, Groß-Wieltsch, Ute, Sykora, Karl Walter, Borkhardt, Arndt, Kulozik, Andreas E., Schrappe, Martin, Nowasz, Christina, Krumbholz, Manuela, Tauer, Josephine T., Claviez, Alexander, Harbott, Jochen, Kreipe, Hans H., Schlegelberger, Brigitte, Thiede, Christian

“…A total of 156 patients (age range 1.3–18.0 years, median 13.2 years; 91 (58.3%) male) with newly diagnosed CML ( N  = 146 chronic phase (CML-CP), N  = 3…”
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Mutations associated with age-related clonal hematopoiesis in PMF patients with rapid progression to myelofibrosis by Bartels, Stephan, Faisal, Muhammad, Büsche, Guntram, Schlue, Jerome, Hasemeier, Britta, Schipper, Elisa, Vogtmann, Julia, Westphal, Lina, Lehmann, Ulrich, Kreipe, Hans

“…Besides histopathological findings there are no indicators of increased risk for fibrotic progression in myeloproliferative neoplasms (MPN). Age-related clonal…”
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Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor by Glocker, Erik-Oliver, Kotlarz, Daniel, Boztug, Kaan, Gertz, E. Michael, Schäffer, Alejandro A, Noyan, Fatih, Perro, Mario, Diestelhorst, Jana, Allroth, Anna, Murugan, Dhaarini, Hätscher, Nadine, Pfeifer, Dietmar, Sykora, Karl-Walter, Sauer, Martin, Kreipe, Hans, Lacher, Martin, Nustede, Rainer, Woellner, Cristina, Baumann, Ulrich, Salzer, Ulrich, Koletzko, Sibylle, Shah, Neil, Segal, Anthony W, Sauerbrey, Axel, Buderus, Stephan, Snapper, Scott B, Grimbacher, Bodo, Klein, Christoph

“…Genetic analyses showed that mutations affecting the interleukin-10 receptor are associated with early-onset colitis. Further molecular analyses showed that…”
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Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN by Gleitz, Hélène F.E., Dugourd, Aurélien J.F., Leimkühler, Nils B., Snoeren, Inge A.M., Fuchs, Stijn N.R., Menzel, Sylvia, Ziegler, Susanne, Kröger, Nicolaus, Triviai, Ioanna, Büsche, Guntram, Kreipe, Hans, Banjanin, Bella, Pritchard, Jessica E., Hoogenboezem, Remco, Bindels, Eric M., Schumacher, Neele, Rose-John, Stefan, Elf, Shannon, Saez-Rodriguez, Julio, Kramann, Rafael, Schneider, Rebekka K.

“…Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) that leads to progressive bone marrow (BM) fibrosis. Although the cellular mutations…”
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Loss of imprinting and allelic switching at the DLK1-MEG3 locus in human hepatocellular carcinoma by Anwar, Sumadi Lukman, Krech, Till, Hasemeier, Britta, Schipper, Elisa, Schweitzer, Nora, Vogel, Arndt, Kreipe, Hans, Lehmann, Ulrich

“…Deregulation of imprinted genes is an important molecular mechanism contributing to the development of cancer in humans. However, knowledge about imprinting…”
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