Search Results - "KREBSBACH, P. H."

Concise Review: The Evolution of human pluripotent stem cell culture: From feeder cells to synthetic coatings by Villa‐Diaz, L.G., Ross, A.M., Lahann, J., Krebsbach, P.H.

“…Current practices to maintain human pluripotent stem cells (hPSCs), which include induced pluripotent stem cells and embryonic stem cells, in an…”
Get full text

Craniofacial Tissue Engineering by Stem Cells by Mao, J.J., Giannobile, W.V., Helms, J.A., Hollister, S.J., Krebsbach, P.H., Longaker, M.T., Shi, S.

“…Craniofacial tissue engineering promises the regeneration or de novo formation of dental, oral, and craniofacial structures lost to congenital anomalies,…”
Get full text

Tissue engineering: state of the art in oral rehabilitation by SCHELLER, E. L., KREBSBACH, P. H., KOHN, D. H.

“…Summary  More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to…”
Get full text

Gene Therapy: Design and Prospects for Craniofacial Regeneration by Scheller, E.L., Krebsbach, P.H.

“…Gene therapy is defined as the treatment of disease by transfer of genetic material into cells. This review will explore methods available for gene transfer as…”
Get full text

Combinatorial Gene Therapy with BMP2/7 Enhances Cranial Bone Regeneration by Koh, J.T., Zhao, Z., Wang, Z., Lewis, I.S., Krebsbach, P.H., Franceschi, R.T.

“…BMP2/7 heterodimer expression by adenovirus can stimulate bone formation at subcutaneous sites. In the present study, we evaluate whether this approach will…”
Get full text

Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds by Taboas, J.M, Maddox, R.D, Krebsbach, P.H, Hollister, S.J

“…Precise control over scaffold material, porosity, and internal pore architecture is essential for tissue engineering. By coupling solid free form (SFF)…”
Get full text

Bisphosphonates Inhibit Expression of p63 by Oral Keratinocytes by Scheller, E.L., Baldwin, C.M., Kuo, S., D’Silva, N.J., Feinberg, S.E., Krebsbach, P.H., Edwards, P.C.

“…Osteonecrosis of the jaw (ONJ), a side-effect of bisphosphonate therapy, is characterized by exposed bone that fails to heal within eight weeks. Healing time…”
Get full text

Transplanted Endothelial Cells Enhance Orthotopic Bone Regeneration by Kaigler, D., Krebsbach, P.H., Wang, Z., West, E.R., Horger, K., Mooney, D.J.

“…The aim of this study was to determine if endothelial cells could enhance bone marrow stromal-cell-mediated bone regeneration in an osseous defect. Using…”
Get full text

Leading with a Consistency of Purpose by Krebsbach, P.H.

“…[...]most of all, we come together to celebrate the diversity and excellence in science that is directed to understanding, preventing, and curing diseases of…”
Get full text

Engineering craniofacial scaffolds by Hollister, SJ, Lin, CY, Saito, E, Schek, RD, Taboas, JM, Williams, JM, Partee, B, Flanagan, CL, Diggs, A, Wilke, EN, Van Lenthe, GH, Müller, R, Wirtz, T, Das, S, Feinberg, SE, Krebsbach, PH

“…Structured : Authors –  Hollister SJ, Lin CY, Saito E, Lin CY, Schek RD, Taboas JM, Williams JM, Partee B, Flanagan CL, Diggs A, Wilke EN, Van Lenthe GH,…”
Get full text

Bone Regeneration in Defects Compromised by Radiotherapy by Hu, W.-W., Ward, B.B., Wang, Z., Krebsbach, P.H.

“…Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized…”
Get full text

Localized viral vector delivery to enhance in situ regenerative gene therapy by HU, W.-W, WANG, Z, HOLLISTER, S. J, KREBSBACH, P. H

“…A lyophilization method was developed to locally release adenoviral vectors directly from biomaterials for in situ regenerative gene therapy. Adenovirus…”
Get full text

Bioengineering strategies for regeneration of craniofacial bone: a review of emerging technologies by Ward, BB, Brown, SE, Krebsbach, PH

“…Oral Diseases (2010) 16, 709–716 Although advances in surgical techniques and bone grafting have significantly improved the functional and cosmetic restoration…”
Get full text

Transgenic Rescue of Enamel Phenotype in Ambn Null Mice by Chun, Y.-H.P., Lu, Y., Hu, Y., Krebsbach, P.H., Yamada, Y., Hu, J.C.-C., Simmer, J.P.

“…Ameloblastin null mice fail to make an enamel layer, but the defects could be due to an absence of functional ameloblastin or to the secretion of a potentially…”
Get full text

Processing of Ameloblastin by MMP-20 by Iwata, T., Yamakoshi, Y., Hu, J.C.-C., Ishikawa, I., Bartlett, J.D., Krebsbach, P.H., Simmer, J.P.

“…Ameloblastin (AMBN) cleavage products are the most abundant non-amelogenin proteins in the enamel matrix of developing teeth. AMBN N-terminal cleavage products…”
Get full text

Advances in Culture and Manipulation of Human Pluripotent Stem Cells by Qian, X., Villa-Diaz, L.G., Krebsbach, P.H.

“…Recent advances in the understanding of pluripotent stem cell biology and emerging technologies to reprogram somatic cells to a stem cell–like state are…”
Get full text

Isolation and Characterization of MC3T3‐E1 Preosteoblast Subclones with Distinct In Vitro and In Vivo Differentiation/Mineralization Potential by Wang, Dian, Christensen, Kurt, Chawla, Kanwal, Xiao, Guozhi, Krebsbach, Paul H., Franceschi, Renny T.

“…A series of subclonal cell lines with high or low differentiation/mineralization potential after growth in the presence of ascorbic acid (AA) were derived from…”
Get full text

Single‐Colony Derived Strains of Human Marrow Stromal Fibroblasts Form Bone After Transplantation In Vivo by Kuznetsov, Sergei A., Krebsbach, Paul H., Satomura, Kazuhito, Kerr, Janet, Riminucci, Mara, Benayahu, Dafna, Robey, Pamela Gehron

“…Populations of marrow stromal fibroblasts (MSFs) can differentiate into functional osteoblasts and form bone in vivo. It is not known, however, what proportion…”
Get full text

Effects of bone morphogenetic protein-2 on proliferation and angiogenesis in oral squamous cell carcinoma by Gao, Q, Tong, W, Luria, J.S, Wang, Z, Nussenbaum, B, Krebsbach, P.H

“…Abstract Experimental data and limited patient experience suggest that rhBMP-2 can be used to regenerate bone in acquired segmental defects of the mandible…”
Get full text

Bone formation in vivo : Comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts by KREBSBACH, P. H, KUZNETSOV, S. A, SATOMURA, K, EMMONS, R. V. B, ROWE, D. W, ROBEY, P. G

“…Marrow stromal fibroblasts (MSFs) are known to contain bone precursor cells. However, the osteogenic potential of human MSFs has been poorly characterized. The…”
Get full text