Search Results - "KRAWETZ, Stephen A"

protein and transcript profiles of human semen by Jodar, Meritxell, Sendler, Edward, Krawetz, Stephen A

“…The increasing use of “-omics” (genomic, transcriptomic, proteomic, epigenomic, and metabolomic) high-throughput measurement technologies over the past decade…”
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Paternal contribution: new insights and future challenges by Krawetz, Stephen A

“…It has been widely held that all that fathers essentially contribute to the next generation is half their genome. However, recent progress towards…”
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Paternal preconception phthalate exposure alters sperm methylome and embryonic programming by Oluwayiose, Oladele A., Marcho, Chelsea, Wu, Haotian, Houle, Emily, Krawetz, Stephen A., Suvorov, Alexander, Mager, Jesse, Richard Pilsner, J.

“…•Male preconception DEHP exposure in mice modified DNA methylomes in F0 sperm and F1 embryo.•Male preconception DEHP exposure altered F1 embryonic…”
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Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants by Estill, Molly S., M.S, Bolnick, Jay M., M.D, Waterland, Robert A., Ph.D, Bolnick, Alan D., M.D, Diamond, Michael P., M.D, Krawetz, Stephen A., Ph.D

“…Objective To evaluate the effect of infertility and intracytoplasmic sperm injection (ICSI) on DNA methylation of offspring. Design Microarray analysis of DNA…”
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Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial by Legro, Richard S, Hansen, Karl R, Diamond, Michael P, Steiner, Anne Z, Coutifaris, Christos, Cedars, Marcelle I, Hoeger, Kathleen M, Usadi, Rebecca, Johnstone, Erica B, Haisenleder, Daniel J, Wild, Robert A, Barnhart, Kurt T, Mersereau, Jennifer, Trussell, J C, Krawetz, Stephen A, Kris-Etherton, Penny M, Sarwer, David B, Santoro, Nanette, Eisenberg, Esther, Huang, Hao, Zhang, Heping

“…Women with obesity and infertility are counseled to lose weight prior to conception and infertility treatment to improve pregnancy rates and birth outcomes,…”
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Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences by Arpanahi, Ali, Brinkworth, Martin, Iles, David, Krawetz, Stephen A, Paradowska, Agnieszka, Platts, Adrian E, Saida, Myriam, Steger, Klaus, Tedder, Philip, Miller, David

“…During the haploid phase of mammalian spermatogenesis, nucleosomal chromatin is ultimately repackaged by small, highly basic protamines to generate an…”
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The sperm nucleus: chromatin, RNA, and the nuclear matrix by Johnson, Graham D, Lalancette, Claudia, Linnemann, Amelia K, Leduc, Frédéric, Boissonneault, Guylain, Krawetz, Stephen A

“…Within the sperm nucleus, the paternal genome remains functionally inert and protected following protamination. This is marked by a structural morphogenesis…”
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A comprehensive analysis of spermatozoal RNA elements in idiopathic infertile males undergoing fertility treatment by Hamilton, Matthew, Russell, Stewart, Swanson, Grace M., Krawetz, Stephen A., Menezes, Karen, Moskovtsev, Sergey I., Librach, Clifford

“…Current approaches to diagnosing male infertility inadequately assess the complexity of the male gamete. Beyond the paternal haploid genome, spermatozoa also…”
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A RNA-Seq Analysis to Describe the Boar Sperm Transcriptome and Its Seasonal Changes by Gòdia, Marta, Estill, Molly, Castelló, Anna, Balasch, Sam, Rodríguez-Gil, Joan E, Krawetz, Stephen A, Sánchez, Armand, Clop, Alex

“…Understanding the molecular basis of cell function and ultimate phenotypes is crucial for the development of biological markers. With this aim, several RNA-seq…”
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Environmental Susceptibility of the Sperm Epigenome During Windows of Male Germ Cell Development by Wu, Haotian, Hauser, Russ, Krawetz, Stephen A., Pilsner, J. Richard

“…Male germ cells require multiple epigenetic reprogramming events during their lifespan to achieve reproductive capacity. An emerging body of compelling data…”
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Male Infertility is a Women's Health Issue-Research and Clinical Evaluation of Male Infertility Is Needed by Turner, Katerina A, Rambhatla, Amarnath, Schon, Samantha, Agarwal, Ashok, Krawetz, Stephen A, Dupree, James M, Avidor-Reiss, Tomer

“…Infertility is a devastating experience for both partners as they try to conceive. Historically, when a couple could not conceive, the woman has carried the…”
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Paternal contributions: New functional insights for spermatozoal RNA by Lalancette, Claudia, Miller, David, Li, Yan, Krawetz, Stephen A.

“…Whereas the presence of RNA in mature ejaculate spermatozoa is now established, its functional significance, if any, is still a matter of debate. This reflects…”
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Sperm centriole assessment identifies male factor infertility in couples with unexplained infertility – a pilot study by Jaiswal, Ankit, Baliu-Souza, Tatiana, Turner, Katerina, Nadiminty, Nagalakshmi, Rambhatla, Amarnath, Agarwal, Ashok, Krawetz, Stephen A., Dupree, James M., Saltzman, Barbara, Schon, Samantha B., Avidor-Reiss, Tomer

“…Unexplained infertility affects about one-third of infertile couples and is defined as the failure to identify the cause of infertility despite extensive…”
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Nuclease Footprints in Sperm Project Past and Future Chromatin Regulatory Events by Johnson, Graham D., Jodar, Meritxell, Pique-Regi, Roger, Krawetz, Stephen A.

“…Nuclear remodeling to a condensed state is a hallmark of spermatogenesis. This is achieved by replacement of histones with protamines. Regions retaining…”
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The Structural Organization of Sperm Chromatin by Wykes, Susan M., Krawetz, Stephen A.

“…The packaging of the male haploid genome within the differentiating spermatid nucleus is facilitated by small basic nuclear proteins called protamines…”
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The controversy, potential and roles of spermatozoal RNA by Miller, David, Ostermeier, G. Charles, Krawetz, Stephen A.

“…The majority of cellular and molecular andrologists endorse the view that the sperm is a vessel for transporting the paternal genome to the waiting egg and…”
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Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs by Platts, Adrian E., Dix, David J., Chemes, Hector E., Thompson, Kary E., Goodrich, Robert, Rockett, John C., Rawe, Vanesa Y., Quintana, Silvina, Diamond, Michael P., Strader, Lillian F., Krawetz, Stephen A.

“…We are coming to appreciate that at fertilization human spermatozoa deliver the paternal genome alongside a suite of structures, proteins and RNAs. Although…”
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Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome by LEGRO, Richard S, BRZYSKI, Robert G, HAISENLEDER, Daniel J, BARNHART, Kurt T, BATES, G. Wright, USADI, Rebecca, LUCIDI, Scott, BAKER, Valerie, TRUSSELL, J. C, KRAWETZ, Stephen A, SNYDER, Peter, OHL, Dana, DIAMOND, Michael P, SANTORO, Nanette, EISENBERG, Esther, HEPING ZHANG, COUTIFARIS, Christos, SCHLAFF, William D, CASSON, Peter, CHRISTMAN, Gregory M, HAO HUANG, QINGSHANG YAN, ALVERO, Ruben

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Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity by Swanson, Grace M, Estill, Molly, Diamond, Michael P, Legro, Richard S, Coutifaris, Christos, Barnhart, Kurt T, Huang, Hao, Hansen, Karl R, Trussell, J C, Coward, R Matthew, Zhang, Heping, Goodrich, Robert, Krawetz, Stephen A

“…In the United States almost 33% of adults are considered obese (BMI > 30 kg/m ). Both animal models and to a lesser extent human studies, have associated BMI,…”
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Differential nuclear scaffold/matrix attachment marks expressed genes by Linnemann, Amelia K., Platts, Adrian E., Krawetz, Stephen A.

“…It is well established that nuclear architecture plays a key role in poising regions of the genome for transcription. This may be achieved using…”
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