Search Results - "KRAWETZ, Roman"

Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation: Does proteoglycan 4 have the ability to buffer the inflammatory response? by Das, Nabangshu, Schmidt, Tannin A, Krawetz, Roman J, Dufour, Antoine

“…Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the…”
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Resetting the clock on arthritis by Krawetz, Roman J

“…While many of intricacies of the mammalian circadian rhythm remain unknown, the role that this physiological clock plays in our everyday lives and within the…”
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Suicide gene‐enabled cell therapy: A novel approach to scalable human pluripotent stem cell quality control by Gysel, Emilie, Larijani, Leila, Kallos, Michael S., Krawetz, Roman J.

“…Abstract There are an increasing number of cell therapy approaches being studied and employed world‐wide. An emerging area in this field is the use of human…”
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Understanding cartilage protection in OA and injury: a spectrum of possibilities by Masson, Anand O, Krawetz, Roman J

“…Osteoarthritis (OA) is a prevalent musculoskeletal disease resulting in progressive degeneration of the hyaline articular cartilage within synovial joints…”
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CCL2 But Not CCR2 Is Required for Spontaneous Articular Cartilage Regeneration Post‐Injury by Jablonski, Christina L., Leonard, Catherine, Salo, Paul, Krawetz, Roman J.

“…ABSTRACT The role of the inflammatory response in articular cartilage degeneration and/or repair is often debated. Chemokine networks play a critical role in…”
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MicroRNA‐34a‐5p Promotes Joint Destruction During Osteoarthritis by Endisha, Helal, Datta, Poulami, Sharma, Anirudh, Nakamura, Sayaka, Rossomacha, Evgeny, Younan, Carolen, Ali, Shabana A., Tavallaee, Ghazaleh, Lively, Starlee, Potla, Pratibha, Shestopaloff, Konstantin, Rockel, Jason S., Krawetz, Roman, Mahomed, Nizar N., Jurisica, Igor, Gandhi, Rajiv, Kapoor, Mohit

“…Objective MicroRNA‐34a‐5p (miR‐34a‐5p) expression is elevated in the synovial fluid of patients with late‐stage knee osteoarthritis (OA); however, its exact…”
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Proteoglycan 4 (PRG4) treatment improves skin wound healing in a porcine model by Ninkovic, Nicoletta, Sparks, Holly D., Ponjevic, Dragana, Muench, Greg, Biernaskie, Jeff A., Krawetz, Roman J.

“…Proteoglycan 4 (PRG4) is a boundary lubricant originally identified in articular cartilage and has been since shown to have immunomodulation and antifibrotic…”
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Serum and synovial fluid cytokine profiling in hip osteoarthritis: distinct from knee osteoarthritis and correlated with pain by Ren, Guomin, Lutz, Ian, Railton, Pamela, Wiley, J Preston, McAllister, Jenelle, Powell, James, Krawetz, Roman J

“…Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between…”
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Enumeration and Localization of Mesenchymal Progenitor Cells and Macrophages in Synovium from Normal Individuals and Patients with Pre-Osteoarthritis or Clinically Diagnosed Osteoarthritis by O'Brien, Kate, Tailor, Pankaj, Leonard, Catherine, DiFrancesco, Lisa M, Hart, David A, Matyas, John R, Frank, Cyril B, Krawetz, Roman J

“…Osteoarthritis (OA) is a degenerative disorder characterized by chondrocyte apoptosis and degeneration of articular cartilage resulting in loss of mobility and…”
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Epidural fat mesenchymal stem cells: Important microenvironmental regulators in health, disease, and regeneration: Do EF-MSCs play a role in dural homeostasis/maintenance? by Shah, Sophia, Mudigonda, Sathvika, Mitha, Alim P, Salo, Paul, Krawetz, Roman J

“…Mesenchymal stem cells (MSCs) are present in fat tissues throughout the body, yet little is known regarding their biological role within epidural fat. We…”
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Synovial fluid mesenchymal progenitor cells from patients with juvenile idiopathic arthritis demonstrate limited self-renewal and chondrogenesis by Krawetz, Roman J., Affan, Asmaa, Leonard, Catherine, Veeramreddy, Dwaraka Natha, Fichadiya, Akash, Martin, Liam, Schmeling, Heinrike

“…Juvenile idiopathic arthritis (JIA) is a heterogeneous group of inflammatory diseases affecting joints with a prevalence of one in a thousand children. There…”
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Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury by Ferrie, Leah, Premnath, Priyatha, Olsen, Alexandra, Larijani, Leila, Besler, Bryce A., Rancourt, Derrick E., Duncan, Neil A., Underhill, T. Michael, Krawetz, Roman J.

“…Promoting bone healing including fracture non-unions are promising targets for bone tissue engineering due to the limited success of current clinical treatment…”
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High spatial resolution analysis using automated indentation mapping differentiates biomechanical properties of normal vs. degenerated articular cartilage in mice by Masson, Anand O, Besler, Bryce, Edwards, W Brent, Krawetz, Roman J

“…Characterizing the biomechanical properties of articular cartilage is crucial to understanding processes of tissue homeostasis vs. degeneration. In mouse…”
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Absence of p21(WAF1/CIP1/SDI1) protects against osteopenia and minimizes bone loss after ovariectomy in a mouse model by Premnath, Priyatha, Ferrie, Leah, Louie, Dante, Boyd, Steven, Krawetz, Roman

“…p21(WAF1/CIP1/SDI1) is a critical sentinel of the cell cycle that plays an important role in determining cell fate with respect to proliferation,…”
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Synovial fluid progenitors expressing CD90+ from normal but not osteoarthritic joints undergo chondrogenic differentiation without micro-mass culture by Krawetz, Roman J, Wu, Yiru Elizabeth, Martin, Liam, Rattner, Jerome B, Matyas, John R, Hart, David A

“…Mesenchymal progenitor cells (MPCs) can differentiate into osteoblasts, adipocytes, and chondrocytes, and are in part responsible for maintaining tissue…”
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Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation by Das, Nabangshu, Schmidt, Tannin A., Krawetz, Roman J., Dufour, Antoine

“…Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the…”
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Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation by Menon, Nikhil G., Goyal, Ruchi, Lema, Carolina, Woods, Paige S., Tanguay, Adam P., Morin, Alyssa A., Das, Nabangshu, Jay, Gregory D., Krawetz, Roman J., Dufour, Antoine, Shapiro, Linda H., Redfern, Rachel L., Ghosh, Mallika, Schmidt, Tannin A.

“…Dry eye disease (DED) affects hundreds of millions of people worldwide. It is characterized by the production of inflammatory cytokines and chemokines as well…”
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Effect of mechanical strain on the pluripotency of murine embryonic stem cells seeded in a collagen‐I scaffold by Hazenbiller, Olesja, Nasr, Saghar, Krawetz, Roman J., Duncan, Neil A.

“…ABSTRACT The use of embryonic stem cells (ESC) in regenerative medicine is restricted due to the possibility of tumorigenicity after inefficient or incomplete…”
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Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity by Krawetz, Roman J., Wu, Yiru Elizabeth, Bertram, Karri L., Shonak, Anchita, Masson, Anand O., Ren, Guomin, Leonard, Catherine, Kapoor, Mohit, Matyas, John R., Salo, Paul T.

“…Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from…”
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Biochemical Markers for the Early Identification of Osteoarthritis: Systematic Review and Meta-Analysis by Ren, Guomin, Krawetz, Roman J.

“…Background There is a desperate need for the reliable detection of osteoarthritis (OA) at the early stage when patients are likely to benefit most from disease…”
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