Search Results - "KRAUTH‐SIEGEL, R. Luise"

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death by Bogacz, Marta, Krauth-Siegel, R Luise

“…Tryparedoxin peroxidases, distant relatives of glutathione peroxidase 4 in higher eukaryotes, are responsible for the detoxification of lipid-derived…”
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Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase by De Gasparo, Raoul, Halgas, Ondrej, Harangozo, Dora, Kaiser, Marcel, Pai, Emil F., Krauth‐Siegel, R. Luise, Diederich, François

“…Trypanothione reductase (TR) plays a key role in the unique redox metabolism of trypanosomatids, the causative agents of human African trypanosomiasis (HAT),…”
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Inhibitor‐Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes by Wagner, Annika, Le, Thien Anh, Brennich, Martha, Klein, Philipp, Bader, Nicole, Diehl, Erika, Paszek, Daniel, Weickhmann, A. Katharina, Dirdjaja, Natalie, Krauth‐Siegel, R. Luise, Engels, Bernd, Opatz, Till, Schindelin, Hermann, Hellmich, Ute A.

“…Trypanosomal and leishmanial infections claim tens of thousands of lives each year. The metabolism of these unicellular eukaryotic parasites differs from the…”
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Biological Activities of Xanthatin from Xanthium strumarium Leaves by Nibret, Endalkachew, Youns, Mahamoud, Krauth-Siegel, R. Luise, Wink, Michael

“…The objective of the present work was to evaluate the biological activities of the major bioactive compound, xanthatin, and other compounds from Xanthium…”
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In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di- N -oxide Derivatives against Trypanosoma cruzi as Trypanothione Reductase Inhibitors by González-González, Alonzo, Sánchez-Sánchez, Oscar, Krauth-Siegel, R Luise, Bolognesi, Maria Laura, Gớmez-Escobedo, Rogelio, Nogueda-Torres, Benjamín, Vázquez-Jiménez, Lenci K, Saavedra, Emma, Encalada, Rusely, Espinoza-Hicks, José Carlos, Paz-González, Alma D, Rivera, Gildardo

“…American trypanosomiasis is a worldwide health problem that requires attention due to ineffective treatment options. We evaluated n-butyl and isobutyl…”
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A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes by Ebersoll, Samantha, Bogacz, Marta, Günter, Lina M, Dick, Tobias P, Krauth-Siegel, R Luise

“…Trypanosomes have a trypanothione redox metabolism that provides the reducing equivalents for numerous essential processes, most being mediated by tryparedoxin…”
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Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach by Beig, Mathias, Oellien, Frank, Garoff, Linnéa, Noack, Sandra, Krauth-Siegel, R Luise, Selzer, Paul M

“…With the goal to identify novel trypanothione reductase (TR) inhibitors, we performed a combination of in vitro and in silico screening approaches. Starting…”
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Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia by Krauth-Siegel, R. Luise, Bauer, Holger, Schirmer, R. Heiner

“…Parasitic diseases such as sleeping sickness, Chagas' heart disease, and malaria are major health problems in poverty‐stricken areas. Antiparasitic drugs that…”
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Biological Evaluation and X‐ray Co‐crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma by De Gasparo, Raoul, Brodbeck‐Persch, Elke, Bryson, Steve, Hentzen, Nina B., Kaiser, Marcel, Pai, Emil F., Krauth‐Siegel, R. Luise, Diederich, François

“…The tropical diseases human African trypanosomiasis, Chagas disease, and the various forms of leishmaniasis are caused by parasites of the family of…”
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Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei by Roldán, Angela, Comini, Marcelo A., Crispo, Martina, Krauth‐Siegel, R. Luise

“…Summary Lipoamide dehydrogenase (LipDH) is a component of four mitochondrial multienzyme complexes. RNA interference or the deletion of both alleles in…”
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Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase by Cavalli, Andrea, Lizzi, Federica, Bongarzone, Salvatore, Brun, Reto, Luise Krauth-Siegel, R., Bolognesi, Maria Laura

“…Novel quinazoline-type compounds were designed as inhibitors of the parasite specific enzyme trypanothione reductase (TR), and their biological activities were…”
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Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase Inhibition and Antiprotozoal Activities of Diarylamines by Stump, Bernhard, Eberle, Christian, Schweizer, W. Bernd, Kaiser, Marcel, Brun, Reto, Krauth-Siegel, R. Luise, Lentz, Dieter, Diederich, François

“…Pentafluorosulfanyl power! The SF5 group—a novel substituent with striking physicochemical properties—was used as building block for trypanothione reductase…”
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Low-molecular-mass antioxidants in parasites by Krauth-Siegel, R Luise, Leroux, Alejandro E

“…Parasitic infections continue to be a major problem for global human health. Vaccines are practically not available and chemotherapy is highly unsatisfactory…”
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Natural Sesquiterpene Lactones of the 4,15- iso -Atriplicolide Type are Inhibitors of Trypanothione Reductase by Lenz, Mairin, Krauth-Siegel, R Luise, Schmidt, Thomas J

“…In the course of our investigations on the antitrypanosomal potential of sesquiterpene lactones (STL), we have recently reported on the exceptionally strong…”
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Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds by Eberle, Christian, Burkhard, Johannes A., Stump, Bernhard, Kaiser, Marcel, Brun, Reto, Krauth-Siegel, R. Luise, Diederich, François

“…Trypanothione reductase (TR) is a flavoenzyme unique to trypanosomatid parasites and a target for lead discovery programs. Various inhibitor scaffolds have…”
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The cytosolic or the mitochondrial glutathione peroxidase‐type tryparedoxin peroxidase is sufficient to protect procyclic Trypanosoma brucei from iron‐mediated mitochondrial damage and lysis by Schaffroth, Corinna, Bogacz, Marta, Dirdjaja, Natalie, Nißen, Amrei, Krauth‐Siegel, R. Luise

“…Summary African trypanosomes express three virtually identical glutathione peroxidase (Px)‐type enzymes that occur in the cytosol (Px I and II) and…”
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The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes by Bogacz, Marta, Dirdjaja, Natalie, Wimmer, Benedikt, Habich, Carina, Krauth-Siegel, R. Luise

“…Hydroperoxide reduction in African trypanosomes relies on 2-Cys-peroxiredoxins (Prxs) and glutathione peroxidase-type enzymes (Pxs) which both obtain their…”
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Betraying the Parasite's Redox System: Diaryl Sulfide-Based Inhibitors of Trypanothione Reductase: Subversive Substrates and Antitrypanosomal Properties by Stump, Bernhard, Kaiser, Marcel, Brun, Reto, Krauth-Siegel, R. Luise, Diederich, François

“…Subversive substrates. Replacing the 3,4‐dichlorophenyl entity of diphenyl sulfide‐based trypanothione reductase (TR) inhibitors for a nitrofuran moiety led to…”
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An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone by Currier, Rachel B, Ulrich, Kathrin, Leroux, Alejandro E, Dirdjaja, Natalie, Deambrosi, Matías, Bonilla, Mariana, Ahmed, Yasar Luqman, Adrian, Lorenz, Antelmann, Haike, Jakob, Ursula, Comini, Marcelo A, Krauth-Siegel, R Luise

“…Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange…”
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The Dithiol Glutaredoxins of African Trypanosomes Have Distinct Roles and Are Closely Linked to the Unique Trypanothione Metabolism by Ceylan, Sevgi, Seidel, Vera, Ziebart, Nicole, Berndt, Carsten, Dirdjaja, Natalie, Krauth-Siegel, R. Luise

“…Trypanosoma brucei, the causative agent of African sleeping sickness, possesses two dithiol glutaredoxins (Grx1 and Grx2). Grx1 occurs in the cytosol and…”
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