Search Results - "KRAMS, Rob"

Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications by Gijsen, Frank, Katagiri, Yuki, Barlis, Peter, Bourantas, Christos, Collet, Carlos, Coskun, Umit, Daemen, Joost, Dijkstra, Jouke, Edelman, Elazer, Evans, Paul, van der Heiden, Kim, Hose, Rod, Koo, Bon-Kwon, Krams, Rob, Marsden, Alison, Migliavacca, Francesco, Onuma, Yoshinobu, Ooi, Andrew, Poon, Eric, Samady, Habib, Stone, Peter, Takahashi, Kuniaki, Tang, Dalin, Thondapu, Vikas, Tenekecioglu, Erhan, Timmins, Lucas, Torii, Ryo, Wentzel, Jolanda, Serruys, Patrick

“…Abstract…”
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Biomechanical factors in atherosclerosis: mechanisms and clinical implications by Kwak, Brenda R, Bäck, Magnus, Bochaton-Piallat, Marie-Luce, Caligiuri, Giuseppina, Daemen, Mat J A P, Davies, Peter F, Hoefer, Imo E, Holvoet, Paul, Jo, Hanjoong, Krams, Rob, Lehoux, Stephanie, Monaco, Claudia, Steffens, Sabine, Virmani, Renu, Weber, Christian, Wentzel, Jolanda J, Evans, Paul C

“…Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall (radial, circumferential and longitudinal forces) or on the…”
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Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis by Seneviratne, Anusha N, Edsfeldt, Andreas, Cole, Jennifer E, Kassiteridi, Christina, Swart, Maarten, Park, Inhye, Green, Patricia, Khoyratty, Tariq, Saliba, David, Goddard, Michael E, Sansom, Stephen N, Goncalves, Isabel, Krams, Rob, Udalova, Irina A, Monaco, Claudia

“…BACKGROUND:Myeloid cells are central to atherosclerotic lesion development and vulnerable plaque formation. Impaired ability of arterial phagocytes to uptake…”
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Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress by CHENG, Caroline, TEMPEL, Dennie, VAN HAPEREN, Rien, VAN DER BAAN, Arjen, GROSVELD, Frank, DAEMEN, Mat J. A. P, KRAMS, Rob, DE CROM, Rini

“…Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting…”
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Editorial: Computational modelling of cardiovascular hemodynamics and machine learning by Bourantas, Christos, Torii, Ryo, Karabasov, Sergey, Krams, Rob

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Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State by ZAKKAR, Mustafa, VAN DER HEIDEN, Kim, HASKARD, Dorian O, MASON, Justin C, EVANS, Paul C, LUONG, Le Anh, CHAUDHURY, Hera, CUHLMANN, Simon, HAMDULAY, Shahir S, KRAMS, Rob, EDIRISINGHE, Indika, RAHMAN, Irfan, CARLSEN, Harald

“…Proinflammatory mediators influence atherosclerosis by inducing adhesion molecules (eg, VCAM-1) on endothelial cells (ECs) via signaling intermediaries…”
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Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo by Baeriswyl, Daniel C., Prionisti, Ioanna, Peach, Tom, Tsolkas, Grigoris, Chooi, Kok Yean, Vardakis, John, Morel, Sandrine, Diagbouga, Mannekomba R., Bijlenga, Philippe, Cuhlmann, Simon, Evans, Paul, Kwak, Brenda R., Ventikos, Yiannis, Krams, Rob

“…Intracranial aneurysms are associated with disturbed velocity patterns, and chronic inflammation, but the relevance for these findings are currently unknown…”
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Mammalian synthetic biology: emerging medical applications by Kis, Zoltán, Pereira, Hugo Sant'Ana, Homma, Takayuki, Pedrigi, Ryan M., Krams, Rob

“…In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology. We start with simple mammalian…”
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Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events by Bourantas, Christos V., Zanchin, Thomas, Torii, Ryo, Serruys, Patrick W., Karagiannis, Alexios, Ramasamy, Anantharaman, Safi, Hannah, Coskun, Ahmet Umit, Koning, Gerhard, Onuma, Yoshinobu, Zanchin, Christian, Krams, Rob, Mathur, Anthony, Baumbach, Andreas, Mintz, Gary, Windecker, Stephan, Lansky, Alexandra, Maehara, Akiko, Stone, Peter H., Raber, Lorenz, Stone, Gregg W.

“…This study examined the value of endothelial shear stress (ESS) estimated in 3-dimensional quantitative coronary angiography (3D-QCA) models in detecting…”
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Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells by Pfenniger, Anna, Wong, Cindy, Sutter, Esther, Cuhlmann, Simon, Dunoyer-Geindre, Sylvie, Mach, François, Horrevoets, Anton J, Evans, Paul C, Krams, Rob, Kwak, Brenda R

“…Abstract High laminar shear stress (HLSS) is vasculoprotective partly through induction of Kruppel-like factor 2 (KLF2). Connexin37 (Cx37) is highly expressed…”
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Final proximal post-dilatation is necessary after kissing balloon in bifurcation stenting by FOIN, Nicolas, SECCO, Gioel G, GHILENCEA, Liviu, KRAMS, Rob, DI MARIO, Carlo

“…High rates of restenosis and stent thrombosis are still often observed after bifurcation stenting despite the recommended stent post-dilatation using the…”
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A physics-based machine learning technique rapidly reconstructs the wall-shear stress and pressure fields in coronary arteries by Morgan, Benjamin, Murali, Amal Roy, Preston, George, Sima, Yidnekachew Ayele, Marcelo Chamorro, Luis Alberto, Bourantas, Christos, Torii, Ryo, Mathur, Anthony, Baumbach, Andreas, Jacob, Marc C., Karabasov, Sergey, Krams, Rob

“…With the global rise of cardiovascular disease including atherosclerosis, there is a high demand for accurate diagnostic tools that can be used during a short…”
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Large variations in absolute wall shear stress levels within one species and between species by Cheng, Caroline, Helderman, Frank, Tempel, Dennie, Segers, Dolf, Hierck, Beerend, Poelmann, Rob, van Tol, Arie, Duncker, Dirk J, Robbers-Visser, Danielle, Ursem, Nicolette T.C, van Haperen, Rien, Wentzel, Jolanda J, Gijsen, Frank, van der Steen, Anton F.W, de Crom, Rini, Krams, Rob

“…Abstract Wall shear stress (WSS), the frictional force between blood and endothelium, is an important determinant of vascular function. It is generally assumed…”
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Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis by Van der Heiden, Kim, Hierck, Beerend P, Krams, Rob, de Crom, Rini, Cheng, Caroline, Baiker, Martin, Pourquie, Mathieu J.B.M, Alkemade, Fanneke E, DeRuiter, Marco C, Gittenberger-de Groot, Adriana C, Poelmann, Robert E

“…Abstract Atherosclerosis develops in the arterial system at sites of low as well as low and oscillating shear stress. Previously, we demonstrated a…”
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Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique by Cheng, Caroline, van Haperen, Rien, de Waard, Monique, van Damme, Luc C.A., Tempel, Dennie, Hanemaaijer, Laurens, van Cappellen, Gert W.A., Bos, Joop, Slager, Cornelis J., Duncker, Dirk J., van der Steen, Anton F.W., de Crom, Rini, Krams, Rob

“…The focal location of atherosclerosis in the vascular tree is correlated with local variations in shear stress. We developed a method to induce defined…”
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Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells by Herault, Sean, Naser, Jarka, Carassiti, Daniele, Chooi, K. Yean, Nikolopoulou, Rosa, Font, Marti Llopart, Patel, Miten, Pedrigi, Ryan, Krams, Rob

“…Shear stress is known to affect many processes in (patho-) physiology through a complex, multi-molecular mechanism, termed mechanotransduction. The sheer…”
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Assessment of Unstable Atherosclerosis in Mice by Jackson, Christopher L, Bennett, Martin R, Biessen, Erik A.L, Johnson, Jason L, Krams, Rob

“…There is an urgent need for representative animal models where prospective examination of the events leading up to plaque rupture and the rupture process…”
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Editorial: Computational modeling for assessing coronary artery pathophysiology by Çap, Murat, Torii, Ryo, Onuma, Yoshinobu, Krams, Rob, Bennett, Martin R, Stone, Peter H, Serruys, Patrick W, Bourantas, Christos V

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Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque by Evans, Rhiannon J, Lavin, Begoña, Phinikaridou, Alkystis, Chooi, Kok Yean, Mohri, Zahra, Wong, Eunice, Boyle, Joseph J, Krams, Rob, Botnar, René, Long, Nicholas J

“…Cardiovascular disease remains a leading cause of death worldwide, with vulnerable plaque rupture the underlying cause of many heart attacks and strokes. Much…”
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Elevated uptake of plasma macromolecules by regions of arterial wall predisposed to plaque instability in a mouse model by Mohri, Zahra, Rowland, Ethan M, Clarke, Lindsey A, De Luca, Amalia, Peiffer, Véronique, Krams, Rob, Sherwin, Spencer J, Weinberg, Peter D

“…Atherosclerosis may be triggered by an elevated net transport of lipid-carrying macromolecules from plasma into the arterial wall. We hypothesised that whether…”
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