Search Results - "KRAJA, Aldi"

Trends in Dietary Sodium Intake in the United States and the Impact of USDA Guidelines: NHANES 1999-2016 by Brouillard, Adam M., Kraja, Aldi T., Rich, Michael W.

“…Moderation in sodium consumption is recommended to reduce morbidity and mortality; however, trends in intake and the impact of guidelines have not been…”
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Four Genome-Wide Association Studies Identify New Extreme Longevity Variants by Sebastiani, Paola, Gurinovich, Anastasia, Bae, Harold, Andersen, Stacy, Malovini, Alberto, Atzmon, Gil, Villa, Francesco, Kraja, Aldi T, Ben-Avraham, Danny, Barzilai, Nir, Puca, Annibale, Perls, Thomas T

“…The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by…”
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A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses by Baranski, Thomas J, Kraja, Aldi T, Fink, Jill L, Feitosa, Mary, Lenzini, Petra A, Borecki, Ingrid B, Liu, Ching-Ti, Cupples, L Adrienne, North, Kari E, Province, Michael A

“…Human GWAS of obesity have been successful in identifying loci associated with adiposity, but for the most part, these are non-coding SNPs whose function, or…”
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Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists by Yanek, Lisa R, Kraja, Aldi T, Faraday, Nauder, Lin, Shiow J, O'Donnell, Christopher J, Yang, Qiong, Province, Michael A, Becker, Lewis C, Chen, Ming-Huei, Becker, Diane M, Larson, Martin G, Johnson, Andrew D, Tofler, Geoffrey

“…Platelet function mediates both beneficial and harmful effects on human health, but few genes are known to contribute to variability in this process. We tested…”
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Gene-lifestyle interactions in the genomics of human complex traits by Laville, Vincent, Majarian, Timothy, Sung, Yun J, Schwander, Karen, Feitosa, Mary F, Chasman, Daniel I, Bentley, Amy R, Rotimi, Charles N, Cupples, L Adrienne, de Vries, Paul S, Brown, Michael R, Morrison, Alanna C, Kraja, Aldi T, Province, Mike, Gu, C Charles, Gauderman, W James, Rao, D C, Manning, Alisa K, Aschard, Hugues

“…The role and biological significance of gene-environment interactions in human traits and diseases remain poorly understood. To address these questions, the…”
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A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium by KRAJA, Aldi T, VAIDYA, Dhananjay, ABSHER, Devin, GUO LI, QUNYUAN ZHANG, FEITOSA, Mary F, GLAZIER, Nicole L, HARITUNIANS, Talin, HARTIKAINEN, Anna-Liisa, KNOWLES, Joshua W, NORTH, Kari E, IRIBARREN, Carlos, PANKOW, James S, KRAL, Brian, YANEK, Lisa, O'REILLY, Paul F, MCCARTHY, Mark I, JAQUISH, Cashell, COUPER, David J, CHAKRAVARTI, Aravinda, PSATY, Bruce M, BECKER, Lewis C, PROVINCE, Michael A, GOODARZI, Mark O, BOERWINKLE, Eric, QUERTERMOUS, Thomas, PALOTIE, Leena, JARVELIN, Marjo-Riitta, BECKER, Diane M, KARDIA, Sharon L. R, ROTTER, Jerome I, CHEN, Yii-Der Ida, BORECKI, Ingrid B, ASSIMES, Themistocles L, KULLO, Iftikhar J, SOVIO, Ulla, MATHIAS, Rasika A, SUN, Yan V, FRANCESCHINI, Nora

“…OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an…”
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Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36[S] by Love-Gregory, Latisha, Kraja, Aldi T., Allum, Fiona, Aslibekyan, Stella, Hedman, Åsa K., Duan, Yanan, Borecki, Ingrid B., Arnett, Donna K., McCarthy, Mark I., Deloukas, Panos, Ordovas, Jose M., Hopkins, Paul N., Grundberg, Elin, Abumrad, Nada A.

“…Cluster of differentiation 36 (CD36) variants influence fasting lipids and risk of metabolic syndrome, but their impact on postprandial lipids, an independent…”
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Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization by Ma, Xiucui, Mani, Kartik, Liu, Haiyan, Kovacs, Attila, Murphy, John T, Foroughi, Layla, French, Brent A, Weinheimer, Carla J, Kraja, Aldi, Benjamin, Ivor J, Hill, Joseph A, Javaheri, Ali, Diwan, Abhinav

“…Background Mutations in αB-crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting ( IF ) is a…”
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The genetics of obesity and the metabolic syndrome by Monda, Keri L, North, Kari E, Hunt, Steven C, Rao, D C, Province, Michael A, Kraja, Aldi T

“…In this review, we discuss the genetic architecture of obesity and the metabolic syndrome, highlighting recent advances in identifying genetic variants and…”
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An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group by Sung, Yun Ju, Winkler, Thomas W., Manning, Alisa K., Aschard, Hugues, Gudnason, Vilmundur, Harris, Tamara B., Smith, Albert V., Boerwinkle, Eric, Brown, Michael R., Morrison, Alanna C., Fornage, Myriam, Lin, Li-An, Richard, Melissa, Bartz, Traci M., Psaty, Bruce M., Hayward, Caroline, Polasek, Ozren, Marten, Jonathan, Rudan, Igor, Feitosa, Mary F., Kraja, Aldi T., Province, Michael A., Deng, Xuan, Fisher, Virginia A., Zhou, Yanhua, Bielak, Lawrence F., Smith, Jennifer, Huffman, Jennifer E., Padmanabhan, Sandosh, Smith, Blair H., Ding, Jingzhong, Liu, Yongmei, Lohman, Kurt, Bouchard, Claude, Rankinen, Tuomo, Rice, Treva K., Arnett, Donna, Schwander, Karen, Guo, Xiuqing, Palmas, Walter, Rotter, Jerome I., Alfred, Tamuno, Bottinger, Erwin P., Loos, Ruth J. F., Amin, Najaf, Franco, Oscar H., van Duijn, Cornelia M., Vojinovic, Dina, Chasman, Daniel I., Ridker, Paul M., Rose, Lynda M., Kardia, Sharon, Zhu, Xiaofeng, Rice, Kenneth, Borecki, Ingrid B., Rao, Dabeeru C., Gauderman, W. James, Cupples, L. Adrienne

“…ABSTRACT Studying gene‐environment (G × E) interactions is important, as they extend our knowledge of the genetic architecture of complex traits and may help…”
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CANDID: a flexible method for prioritizing candidate genes for complex human traits by Hutz, Janna E., Kraja, Aldi T., McLeod, Howard L., Province, Michael A.

“…Genomewide studies and localized candidate gene approaches have become everyday study designs for identifying polymorphisms in genes that influence complex…”
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Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster? by Kraja, Aldi T, Province, Michael A, Arnett, Donna, Wagenknecht, Lynne, Tang, Weihong, Hopkins, Paul N, Djoussé, Luc, Borecki, Ingrid B

“…The metabolic syndrome (MetS), in addition to its lipid, metabolic, and anthropomorphic characteristics, is associated with a prothrombotic and the…”
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An Overview of the Genomics of Metabolic Syndrome by Taylor, Jacquelyn Y., Kraja, Aldi T., de las Fuentes, Lisa, Stanfill, Ansley Grimes, Clark, Ashley, Cashion, Ann

“…Purpose: This article provides a brief overview of the diagnostic criteria and genomic risk factors for the components of metabolic syndrome (MetS). Organizing…”
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Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c ) levels in non-diabetic subjects: The Long Life Family Study (LLFS) by An, Ping, Miljkovic, Iva, Thyagarajan, Bharat, Kraja, Aldi T, Daw, E. Warwick, Pankow, James S, Selvin, Elizabeth, Kao, W.H. Linda, Maruthur, Nisa M, Nalls, Micahel A, Liu, Yongmei, Harris, Tamara B, Lee, Joseph H, Borecki, Ingrid B, Christensen, Kaare, Eckfeldt, John H, Mayeux, Richard, Perls, Thomas T, Newman, Anne B, Province, Michael A

“…Abstract Objective Glycated hemoglobin (HbA1c ) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of…”
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Genetic Analysis of 16 NMR-Lipoprotein Fractions in Humans, the GOLDN Study by Kraja, Aldi T., Borecki, Ingrid B., Tsai, Michael Y., Ordovas, Jose M., Hopkins, Paul N., Lai, Chao-Qiang, Frazier-Wood, Alexis C., Straka, Robert J., Hixson, James E., Province, Michael A., Arnett, Donna K.

“…Sixteen nuclear magnetic resonance (NMR) spectroscopy lipoprotein measurements of more than 1,000 subjects of GOLDN study, at fasting and at 3.5 and 6 h after…”
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Genome-Wide Discovery of Loci Influencing Chemotherapy Cytotoxicity by Watters, James W., Kraja, Aldi, Meucci, Melissa A., Province, Michael A., McLeod, Howard L., Kipnis, David M.

“…Little is known about the heritability of chemotherapy activity or the identity of genes that may enable the individualization of cancer chemotherapy. Although…”
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Genetic Effect on Blood Pressure Is Modulated by Age: The Hypertension Genetic Epidemiology Network Study by Shi, Gang, Gu, Chi C, Kraja, Aldi T, Arnett, Donna K, Myers, Richard H, Pankow, James S, Hunt, Steven C, Rao, Dabeeru C

“…Genome-wide linkage analysis was performed for systolic and diastolic blood pressures in the Hypertension Genetic Epidemiology Network. We investigated the…”
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CMDS: a population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data by Zhang, Qunyuan, Ding, Li, Larson, David E., Koboldt, Daniel C., McLellan, Michael D., Chen, Ken, Shi, Xiaoqi, Kraja, Aldi, Mardis, Elaine R., Wilson, Richard K., Borecki, Ingrid B., Province, Michael A.

“…Motivation: DNA copy number aberration (CNA) is a hallmark of genomic abnormality in tumor cells. Recurrent CNA (RCNA) occurs in multiple cancer samples across…”
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Novel Genetic Loci Associated With Retinal Microvascular Diameter by Jensen, Richard A, Sim, Xueling, Smith, Albert Vernon, Li, Xiaohui, Jakobsdóttir, Jóhanna, Cheng, Ching-Yu, Brody, Jennifer A, Cotch, Mary Frances, Mcknight, Barbara, Klein, Ronald, Wang, Jie Jin, Kifley, Annette, Harris, Tamara B, Launer, Lenore J, Taylor, Kent D, Klein, Barbara E.K, Raffel, Leslie J, Li, Xiang, Ikram, M Arfan, Klaver, Caroline C, van der Lee, Sven J, Mutlu, Unal, Hofman, Albert, Uitterlinden, André G, Liu, Chunyu, Kraja, Aldi T, Mitchell, Paul, Gudnason, Vilmundur, Rotter, Jerome I, Boerwinkle, Eric, van Duijn, Cornelia M, Psaty, Bruce M, Wong, Tien Y

“…BACKGROUND—There is increasing evidence that retinal microvascular diameters are associated with cardiovascular and cerebrovascular conditions. The shared…”
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Fenofibrate and metabolic syndrome by Kraja, Aldi T, Province, Michael A, Straka, Robert J, Ordovas, Jose M, Borecki, Ingrid B, Arnett, Donna K

“…The fibric acid derivative, fenofibrate (FF) has been used in the US since 1998 to manage patients with dyslipidemia. Typical changes in serum lipids as result…”
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