Search Results - "KRAFT, Andrew S"

The 2014 Surgeon General's report: “The Health Consequences of Smoking–50 Years of Progress”: A paradigm shift in cancer care by Warren, Graham W., Alberg, Anthony J., Kraft, Andrew S., Cummings, K. Michael

“…To the authors' knowledge, the 2014 Surgeon General's report “The Health Consequences of Smoking‐50 Years of Progress” provides the first large evidence review…”
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OER‐073: A multicenter phase 2 study evaluating the role of pazopanib in angiosarcoma by Thiebaud, Julio Alvarenga, Ravi, Vinod, Litwin, Samuel, Schuetze, Scott M., Movva, Sujana, Agulnik, Mark, Kraft, Andrew S., Tetzlaff, Eric D., Somaiah, Neeta, Mehren, Margaret

“…Background Angiosarcomas are rare mesenchymal sarcomas that can present as primary cutaneous or noncutaneous disease. They express a variety of vascular…”
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Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death by Song, Jin H, Kang, Hyun-Jin, Luevano, Libia A, Gokhale, Vijay, Wu, Kui, Pandey, Ritu, Sherry Chow, H-H, Hurley, Laurence H, Kraft, Andrew S

“…Increased telomerase activity is associated with malignancy and poor prognosis in human cancer, but the development of targeted agents has not yet provided…”
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PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species by Warfel, Noel A, Sainz, Alva G, Song, Jin H, Kraft, Andrew S

“…Intratumoral hypoxia is a significant obstacle to the successful treatment of solid tumors, and it is highly correlated with metastasis, therapeutic…”
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Angiosarcoma treated successfully with anti-PD-1 therapy - a case report by Sindhu, Simran, Gimber, Lana H, Cranmer, Lee, McBride, Ali, Kraft, Andrew S

“…Angiosarcomas are tumors of malignant endothelial origin that have a poor prognosis with a five-year survival of less than 40%. These tumors can be found in…”
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Elevation of Receptor Tyrosine Kinases by Small Molecule AKT Inhibitors in Prostate Cancer Is Mediated by Pim-1 by BO CEN, MAHAJAN, Sandeep, WENXUE WANG, KRAFT, Andrew S

“…The PI3K/AKT pathway is hyperactivated in prostate cancer but its effective therapeutic targeting has proven difficult. In particular, the antitumor activity…”
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Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas by MAKI, Robert G, D'ADAMO, David R, TAKIMOTO, Chris H, KRAFT, Andrew S, ELIAS, Anthony D, BROCKSTEIN, Bruce, BLACHERE, Nathalie E, EDGAR, Mark A, SCHWARTZ, Lawrence H, QIN, Li-Xuan, ANTONESCU, Cristina R, SCHWARTZ, Gary K, KEOHAN, Mary L, SAULLE, Michael, SCHUETZE, Scott M, UNDEVIA, Samir D, LIVINGSTON, Michael B, COONEY, Matthew M, HENSLEY, Martee L, MITA, Monica M

“…PURPOSE Since activity of sorafenib was observed in sarcoma patients in a phase I study, we performed a multicenter phase II study of daily oral sorafenib in…”
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Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial by Schwartz, Gary K, Prof, Tap, William D, MD, Qin, Li-Xuan, PhD, Livingston, Michael B, Prof, Undevia, Samir D, MD, Chmielowski, Bartosz, MD, Agulnik, Mark, MD, Schuetze, Scott M, MD, Reed, Damon R, MD, Okuno, Scott H, Prof, Ludwig, Joseph A, MD, Keedy, Vicki, MD, Rietschel, Petra, MD, Kraft, Andrew S, Prof, Adkins, Douglas, Prof, Van Tine, Brian A, MD, Brockstein, Bruce, MD, Yim, Vincent, BA, Bitas, Christiana, BA, Abdullah, Abdul, BA, Antonescu, Cristina R, Prof, Condy, Mercedes, RN, Dickson, Mark A, MD, Vasudeva, Shyamprasad Deraje, MA, Ho, Alan L, MD, Doyle, L Austin, Prof, Chen, Helen X, Prof, Maki, Robert G, Prof

“…Summary Background Preclinical studies have shown synergistic antitumour activity by inhibition of insulin-like growth factor-1 receptor (IGF-1R) and mTOR. The…”
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Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases by Xia, Zuping, Knaak, Christian, Ma, Jian, Beharry, Zanna M, McInnes, Campbell, Wang, Wenxue, Kraft, Andrew S, Smith, Charles D

“…The Pim protein kinases are frequently overexpressed in prostate cancer and certain forms of leukemia and lymphoma…”
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Pim protein kinases regulate energy metabolism and cell growth by Beharry, Zanna, Mahajan, Sandeep, Zemskova, Marina, Lin, Ying-Wei, Tholanikunnel, Baby G, Xia, Zuping, Smith, Charles D, Kraft, Andrew S

“…The serine/threonine Pim kinases are overexpressed in solid cancers and hematologic malignancies and promote cell growth and survival. Here, we find that a…”
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EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics by Bearss, Jeremiah J, Padi, Sathish KR, Singh, Neha, Cardo-Vila, Marina, Song, Jin H, Mouneimne, Ghassan, Fernandes, Nikita, Li, Yang, Harter, Matthew R, Gard, Jaime MC, Cress, Anne E, Peti, Wolfgang, Nelson, Andrew DL, Buchan, J Ross, Kraft, Andrew S, Okumura, Koichi

“…Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P-bodies) are critical…”
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PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth by Singh, Neha, Padi, Sathish K. R., Bearss, Jeremiah J., Pandey, Ritu, Okumura, Koichi, Beltran, Himisha, Song, Jin H., Kraft, Andrew S., Olive, Virginie

“…The proviral integration site for Moloney murine leukemia virus (PIM) serine/threonine kinases have an oncogenic and prosurvival role in hematological and…”
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The Pim-1 Protein Kinase Is an Important Regulator of MET Receptor Tyrosine Kinase Levels and Signaling by Cen, Bo, Xiong, Ying, Song, Jin H., Mahajan, Sandeep, DuPont, Rachel, McEachern, Kristen, DeAngelo, Daniel J., Cortes, Jorge E., Minden, Mark D., Ebens, Allen, Mims, Alice, LaRue, Amanda C., Kraft, Andrew S.

“…MET, the receptor for hepatocyte growth factor (HGF), plays an important role in signaling normal and tumor cell migration and invasion. Here, we describe a…”
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ABT-737 Induces Expression of the Death Receptor 5 and Sensitizes Human Cancer Cells to TRAIL-induced Apoptosis by Song, Jin H., Kandasamy, Karthikeyan, Kraft, Andrew S.

“…Because Bcl-2 family members inhibit the ability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis, we investigated…”
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Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer by HOUJIAN CAI, MEMARZADEH, Sanaz, STOYANOVA, Tanya, BEHARRY, Zanna, KRAFT, Andrew S, WITTE, Owen N

“…Elevation of the chromatin repression factor enhancer of zeste homolog (EZH2) is associated with progression and poor prognosis in several human cancers…”
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PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells by Zhang, Fengxue, Beharry, Zanna M., Harris, Thurl E., Lilly, Michael B., Smith, Charles D., Mahajan, Sandeep, Kraft, Andrew S.

“…PIM1 is a serine /threonine kinase that has diverse biological roles in cell survival, proliferation and differentiation.   PIM1 has been implicated in early…”
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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells by Beharry, Zanna, Zemskova, Marina, Mahajan, Sandeep, Zhang, Fengxue, Ma, Jian, Xia, Zuping, Lilly, Michael, Smith, Charles D, Kraft, Andrew S

“…The Pim protein kinases play important roles in cancer development and progression, including prostate tumors and hematologic malignancies. To investigate the…”
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Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3′-untranslated region by Kandasamy, Karthikeyan, Kraft, Andrew S

“…Addition of proteasome inhibitor PS-341 (VELCADE, bortezomib) to prostate cancer cells enhances cell death mediated by tumor necrosis factor–related…”
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Sustained response to pembrolizumab in recurrent perivascular epithelioid cell tumor with elevated expression of programmed death ligand: a case report by McBride, Ali, Garcia, Andrew J, Sanders, Lauren J, Yiu, Kelly, Cranmer, Lee D, Kuo, Phillip H, Kay, Matthew, Kraft, Andrew S

“…Abstract Background Perivascular epithelioid cell tumors are defined by the World Health Organization as “a collection of rare mesenchymal tumors composed of…”
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Pim1 Serine/Threonine Kinase Regulates the Number and Functions of Murine Hematopoietic Stem Cells by An, Ningfei, Lin, Ying‐Wei, Mahajan, Sandeep, Kellner, Joshua N., Wang, Yong, Li, Zihai, Kraft, Andrew S., Kang, Yubin

“…The genes and pathways that govern the functions and expansion of hematopoietic stem cells (HSC) are not completely understood. In this study, we investigated…”
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