Search Results - "KOZIN, Sergey V"

CXCL12 (SDF1α)-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies? by DUDS, Dan G, KOZIN, Sergey V, KIRKPATRICK, Nathaniel D, LEI XU, FUKUMURA, Dai, JAIN, Rakesh K

“…Addition of multiple molecularly targeted agents to the existing armamentarium of chemotherapeutics and radiotherapies represents a significant advance in the…”
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Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy by Ager, Eleanor I, Kozin, Sergey V, Kirkpatrick, Nathaniel D, Seano, Giorgio, Kodack, David P, Askoxylakis, Vasileios, Huang, Yuhui, Goel, Shom, Snuderl, Matija, Muzikansky, Alona, Finkelstein, Dianne M, Dransfield, Daniel T, Devy, Laetitia, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K

“…Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Orthotopic murine breast tumors (4T1 and E0771…”
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Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors by TONG, Ricky T, BOUCHER, Yves, KOZIN, Sergey V, WINKLER, Frank, HICKLIN, Daniel J, JAIN, Rakesh K

“…Elevated interstitial fluid pressure, a hallmark of solid tumors, can compromise the delivery of therapeutics to tumors. Here we show that blocking vascular…”
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Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers by Kozin, Sergey V, Maimon, Nir, Wang, Rong, Gupta, Nisha, Munn, Lance, Jain, Rakesh K, Garkavtsev, Igor

“…SLPI has been implicated in the progression and metastasis of certain cancers. However, the effects of SLPI seem to be tumor-specific and the mechanisms remain…”
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Insights into the Cardiotoxic Effects of Veratrum Lobelianum Alkaloids: Pilot Study by Taldaev, Amir, Terekhov, Roman P., Melnik, Elizaveta V., Belova, Maria V., Kozin, Sergey V., Nedorubov, Andrey A., Pomerantseva, Tatyana Ya, Ramenskaya, Galina V.

“…Jervine, protoveratrine A (proA), and protoveratrine B (proB) are Veratrum alkaloids that are presented in some remedies obtained from Veratrum lobelianum,…”
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Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models by Gupta, Nisha, Ochiai, Hiroki, Hoshino, Yoshinori, Klein, Sebastian, Zustin, Jozef, Ramjiawan, Rakesh R, Kitahara, Shuji, Maimon, Nir, Bazou, Despina, Chiang, Sarah, Li, Sen, Schanne, Daniel H, Jain, Rakesh K, Munn, Lance L, Huang, Peigen, Kozin, Sergey V, Duda, Dan G

“…Radiotherapy (RT) is a standard treatment for patients with advanced prostate cancer (PCa). Previous preclinical studies showed that SDF1α/CXCR4 axis could…”
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Combined Vascular Endothelial Growth Factor–Targeted Therapy and Radiotherapy for Rectal Cancer: Theory and Clinical Practice by Willett, Christopher G., Kozin, Sergey V., Duda, Dan G., di Tomaso, Emmanuelle, Kozak, Kevin R., Boucher, Yves, Jain, Rakesh K.

“…Despite the routine use of adjuvant and neoadjuvant chemoradiotherapy, patients with advanced rectal tumors experience significant rates of treatment failure…”
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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels by Chauhan, Vikash P., Martin, John D., Liu, Hao, Lacorre, Delphine A., Jain, Saloni R., Kozin, Sergey V., Stylianopoulos, Triantafyllos, Mousa, Ahmed S., Han, Xiaoxing, Adstamongkonkul, Pichet, Popović, Zoran, Huang, Peigen, Bawendi, Moungi G., Boucher, Yves, Jain, Rakesh K.

“…Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial…”
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Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors by KOZIN, Sergey V, WINKLER, Frank, GARKAVTSEV, Igor, HICKLIN, Daniel J, JAIN, Rakesh K, BOUCHER, Yves

“…The effects of antiangiogenic therapy on tumors relapsing after irradiation are not known. To this end, we irradiated human tumors growing s.c. in nude mice…”
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Recruitment of Myeloid but not Endothelial Precursor Cells Facilitates Tumor Regrowth after Local Irradiation by KOZIN, Sergey V, KAMOUN, Walid S, YUHUI HUANG, DAWSON, Michelle R, JAIN, Rakesh K, DUDA, Dan G

“…Tumor neovascularization and growth might be promoted by the recruitment of bone marrow-derived cells (BMDC), which include endothelial precursor cells and…”
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The radiopharmaceutical radium-223 has immunomodulatory effects in patients and facilitates anti-programmed death receptor-1 therapy in murine models of bone metastatic prostate cancer by Saylor, Philip J., Kozin, Sergey V., Matsui, Aya, Goldberg, Saveli I., Aoki, Shuichi, Shigeta, Kohei, Mamessier, Emilie, Smith, Matthew R., Michaelson, M. Dror, Lee, Richard J., Duda, Dan G.

“…•Prostate cancer is associated with systemic and local immunosuppression.•The radiopharmaceutical Ra223 may be immunomodulatory.•The inflammatory cytokine IL-6…”
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LC-MS/MS determination of GTS-201, a dipeptide mimetic of the brain-derived neurotrophic factor, and neurotransmitter metabolites with application to a pharmacokinetic study in rats by Markin, Pavel A., Moskaleva, Natalia E., Lebedeva, Svetlana A., Kozin, Sergey V., Grigorevskikh, Ekaterina M., Kolik, Larisa G., Gudasheva, Tatyana A., Appolonova, Svetlana A.

“…Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family with diverse psychopharmacological effects including antidepressant and…”
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Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases by Winkler, Frank, Kozin, Sergey V., Tong, Ricky T., Chae, Sung-Suk, Booth, Michael F., Garkavtsev, Igor, Xu, Lei, Hicklin, Daniel J., Fukumura, Dai, di Tomaso, Emmanuelle, Munn, Lance L., Jain, Rakesh K.

“…The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that antiangiogenic therapy must be combined with cytotoxic therapy for the…”
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Perivascular nitric oxide gradients normalize tumor vasculature by Fukumura, Dai, Kashiwagi, Satoshi, Tsukada, Kosuke, Xu, Lei, Miyazaki, Junichi, Kozin, Sergey V, Tyrrell, James A, Sessa, William C, Gerweck, Leo E, Jain, Rakesh K

“…Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from…”
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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer by Willett, Christopher G, Jain, Rakesh K, Boucher, Yves, di Tomaso, Emmanuelle, Duda, Dan G, Munn, Lance L, Tong, Ricky T, Chung, Daniel C, Sahani, Dushyant V, Kalva, Sanjeeva P, Kozin, Sergey V, Mino, Mari, Cohen, Kenneth S, Scadden, David T, Hartford, Alan C, Fischman, Alan J, Clark, Jeffrey W, Ryan, David P, Zhu, Andrew X, Blaszkowsky, Lawrence S, Chen, Helen X, Shellito, Paul C, Lauwers, Gregory Y

“…The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of human tumors are not known. Here we show here that a single…”
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Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? by Kozin, Sergey V, Duda, Dan G, Munn, Lance L, Jain, Rakesh K

“…Local relapse of tumors after radiation therapy remains a challenge in oncology. To devise rational approaches for preventing this relapse, we have to improve…”
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The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis by Garkavtsev, Igor, Kozin, Sergey V, Chernova, Olga, Xu, Lei, Winkler, Frank, Brown, Edward, Barnett, Gene H, Jain, Rakesh K

“…Gliomas are the most common primary tumours of the central nervous system, with nearly 15,000 diagnosed annually in the United States and a lethality…”
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Validated HPLC-MS/MS method for quantification of ethylmethylhydroxypyridine succinate in rat brain and its application to a pharmacokinetic study by Melnik, Elizaveta V., Petukhov, Alexey E., Kozin, Sergey V., Pomerantseva, Tatyana Ya, Ramenskaya, Galina V.

“…2-ethyl-6-methyl-3-hydroxypyridine (EMHP) succinate is the original antioxidant and antihypoxic drug commonly prescribed in Russia. The objective of this study…”
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Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients by Willett, Christopher G, Boucher, Yves, Duda, Dan G, di Tomaso, Emmanuelle, Munn, Lance L, Tong, Ricky T, Kozin, Sergey V, Petit, Lucine, Jain, Rakesh K, Chung, Daniel C, Sahani, Dushyant V, Kalva, Sanjeeva P, Cohen, Kenneth S, Scadden, David T, Fischman, Alan J, Clark, Jeffrey W, Ryan, David P, Zhu, Andrew X, Blaszkowsky, Lawrence S, Shellito, Paul C, Mino-Kenudson, Mari, Lauwers, Gregory Y

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Evidence for incorporation of bone marrow–derived endothelial cells into perfused blood vessels in tumors by Duda, Dan G., Cohen, Kenneth S., Kozin, Sergey V., Perentes, Jean Y., Fukumura, Dai, Scadden, David T., Jain, Rakesh K.

“…Recent studies have demonstrated that the cellular contribution of the bone marrow to tumor neovascularization is highly complex. In this context, the extent…”
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