Search Results - "KOVACS, Gerald R"

Development of Next-Generation COVID-19 Vaccines: Biomedical Advanced Research and Development Authority (BARDA­)–Supported Phase 2b Study Designs by Wolfe, Daniel N, Arangies, Elizabeth, David, Gloria L, Armstrong, Brian, Scocca, Theresa Z, Fedler, Janel, Natarajan, Ramya, Zhou, James, Jayashankar, Lakshmi, Donis, Ruben, Nesin, Mirjana, Meissner, H Cody, Lemiale, Laurence, Kovacs, Gerald R, Rele, Shyam, Mason, Robin, Cao, Huyen

“…In response to the coronavirus disease 2019 (COVID-19) pandemic, vaccines were quickly and successfully developed and deployed, saving millions of lives…”
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Expression of a foreign gene by recombinant canine distemper virus recovered from cloned DNAs by Parks, Christopher L, Wang, Hai-Ping, Kovacs, Gerald R, Vasilakis, Nikos, Kowalski, Jacek, Nowak, Rebecca M, Lerch, Robert A, Walpita, Pramila, Sidhu, Mohinderjit S, Udem, Stephen A

“…A canine distemper virus (CDV) genomic cDNA clone and expression plasmids required to establish a CDV rescue system were generated from a laboratory-adapted…”
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Eradication of established tumors by vaccination with venezuelan equine encephalitis virus replicon particles delivering human papillomavirus 16 E7 RNA by VELDERS, Markwin P, MCELHINEY, Sue, CASSETTI, Maria Cristina, EIBEN, Gretchen L, HIGGINS, Terry, KOVACS, Gerald R, ELMISHAD, Amira G, KAST, W. Martin, SMITH, Larry R

“…The etiological role of human papillomaviruses (HPV) in cervical and other cancers suggests that therapeutic vaccines directed against requisite viral antigens…”
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THE U.S. GOVERNMENTʼS MEDICAL COUNTERMEASURE PORTFOLIO MANAGEMENT FOR NUCLEAR AND RADIOLOGICAL EMERGENCIES: SYNERGY FROM INTERAGENCY COOPERATION by Grace, Marcy B, Cliffer, Kenneth D, Moyer, Brian R, Coleman, C. Norman, Prasher, Joanna M, Hatchett, Richard, Mercier, John, Manning, Ronald G, Bader, Judith L, Disbrow, Gary L, Kovacs, Gerald R

“…Following the attacks of 11 September 2001, emergency preparedness within the U.S. Department of Health and Human Services, as well as at the Department of…”
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Enhanced genetic rescue of negative-strand RNA viruses: use of an MVA-T7 RNA polymerase vector and DNA replication inhibitors by Kovacs, Gerald R., Parks, Christopher L., Vasilakis, Nikos, Udem, Stephen A.

“…A modified cDNA rescue system that improves recovery of recombinant nonsegmented, negative-strand RNA viruses from cloned DNAs is described. Rescue systems…”
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Regulation of Viral Intermediate Gene Expression by the Vaccinia Virus B1 Protein Kinase by Kovacs, G R, Vasilakis, N, Moss, B

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Transfection-independent production of alphavirus replicon particles based on poxvirus expression vectors by Kovacs, Gerald R, Vasilakis, Nikos, Falvey, Darlene, Gangolli, Seema S, Coleman, John, Kowalski, Jacek, Udem, Stephen A, Zamb, Timothy J

“…This report describes a transfection-independent system for packaging alphavirus replicon vectors using modified vaccinia virus Ankara (MVA) vectors to express…”
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Project NextGen: Developing the Next Generation of COVID-19 Vaccines and Therapeutics to Respond to the Present and Prepare for the Future by Hofmeyer, Kimberly A, Ventura, Christy L, Armstrong, Kimberly L, Houchens, Christopher R, Patel, Sandeep, Disbrow, Gary L, Johnson, Robert A

“…Coronavirus disease 2019 (COVID-19) epidemiology and product landscapes have changed considerably since onset of the pandemic. Safe and effective vaccines and…”
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Use of early baculovirus promoters for continuous expression and efficient processing of foreign gene products in stably transformed lepidopteran cells by Jarvis, D.L. (Texas AandM University, and Texas Agricultural Experiment Station, College Station TX), Fleming, J.G.W, Kovacs, G.R, Summers, M.D, Guarino, L.A

“…Baculoviruses are currently used as vectors for the transient high-level expression of foreign gene products in insect cells. In this study, we demonstrate…”
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A method of alphavirus replicon particle titration based on expression of functional replicase/transcriptase by Gangolli, Seema S., Vasilakis, Nikolaos, Kovacs, Gerald R., Zamb, Timothy J., Kowalski, Jacek

“…Alphavirus replicon particles are being exploited for a variety of purposes both in vitro as gene expression vectors, and in vivo as vaccines or gene therapy…”
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Development of Next-Generation COVID-19 Vaccines: BARDA Supported Phase 2b Study Designs by Wolfe, Daniel N, Arangies, Elizabeth, David, Gloria L, Armstrong, Brian, Scocca, Theresa Z, Fedler, Janel, Natarajan, Ramya, Zhou, James, Jayashankar, Lakshmi, Donis, Ruben, Nesin, Mirjana, Meissner, H Cody, Lemiale, Laurence, Kovacs, Gerald R, Rele, Shyam, Mason, Robin, Cao, Huyen

“…In response to the COVID-19 pandemic, vaccines were quickly and successfully developed and deployed, saving millions of lives globally. While first generation…”
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The vaccinia virus H5R gene encodes late gene transcription factor 4: purification, cloning, and overexpression by Kovacs, G R, Moss, B

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Novel regulatory properties of the IE1 and IE0 transactivators encoded by the baculovirus Autographa californica multicapsid nuclear polyhedrosis virus by Kovacs, G.R. (Harvard Medical School, Boston, MA), Guarino, L.A, Summers, M.D

“…The baculovirus Autographa californica multicapsid nuclear polyhedrosis virus expresses two immediate-early genes from the HindIII-G region (map units 90.4 to…”
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Functional dissection of the Autographa californica nuclear polyhedrosis virus immediate-early 1 transcriptional regulatory protein by Kovacs, G.R. (National Institute of Allergy and Infectious Diseases, Bethesda, MD), Choi, J, Guarino, L.A, Summers, M.D

“…Autographa californica multicapsid nuclear polyhedrosis virus-infected insect cells express a viral immediate-early transcriptional regulatory protein, IE1,…”
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Virus-based vectors for gene expression in mammalian cells: Vaccinia virus by Carroll, Miles W., Kovacs, Gerald R.

“…The chapter presents basic concepts and applications of poxviruses as recombinant expression vectors. Additional focused reviews on poxvirus molecular biology…”
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Transcription of a vaccinia virus late promoter template: requirement for the product of the A2L intermediate-stage gene by Passarelli, A L, Kovacs, G R, Moss, B

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Identification of spliced baculovirus RNAs expressed late in infection by Kovacs, G R, Guarino, L A, Graham, B L, Summers, M D

“…Previous to this study, the Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV) was known to express only one spliced RNA (spliced IE1 or…”
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